{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T22:09:37Z","timestamp":1780092577928,"version":"3.54.0"},"reference-count":63,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T00:00:00Z","timestamp":1644278400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2022,2,8]]},"abstract":"<jats:p>Purpose. The aim of this study was to compare effectiveness and safety of MicroPulse transscleral laser therapy (MP-TLT) using the original MicroPulse P3\u00ae device and continuous-wave transscleral cyclophotocoagulation (CW-TSCPC) using the G-Probe\u00ae device in glaucoma. Methods. Spherical equivalent, intraocular pressure (IOP), best-corrected visual acuity (BCVA), and number of topical or oral ophthalmic pressure-reducing medications were registered at every time point, up to the last follow-up at 12 months. A complete slit-lamp examination was conducted to record the following complications: corneal edema, persistent ocular hypotony (IOP \u22645\u2009mmHg) on two consecutive follow-up visits, choroidal detachment, phthisis bulbi, sympathetic ophthalmia, cystoid macular edema, or other abnormal ocular findings. Success was defined as IOP between 6 and 21\u2009mmHg and &gt;20% reduction in IOP with or without antiglaucoma medications. Results. 47 eyes underwent MP-TLT and 150 CW-TSCPC. At 12 months, success was achieved in 88.6% in the CW-TSCPC group and 87.5% in the MP-TLT group (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                     <\/a:math>\n                  <\/jats:inline-formula>\u2009=\u20090.883). In the CW-TSCPC group, eyes achieved a 42.4% IOP reduction (from 28.3\u2009\u00b1\u200912.3\u2009mmHg to 15.3\u2009\u00b1\u20096.0\u2009mmHg) and a 31.1% reduction (from 22.0\u2009\u00b1\u20097.2\u2009mmHg to 15.7\u2009\u00b1\u20094.8\u2009mmHg) in the MP-TLT group. Visual acuity remained primarily unaltered in both groups. Conclusion. MP-TLT was as effective in lowering IOP as CW-TSCPC and achieved comparable success. Additionally, MP-TLT demonstrated consistent and effective outcomes at every time point. The improved safety profile of MP-TLT allows the therapeutic spectrum to be broadened, granting ophthalmologists\u2019 treatment of glaucoma in earlier stages of glaucoma than those typically treated with CW-TSCPC, i.e., early to moderate and to patients with good central-vision.<\/jats:p>","DOI":"10.1155\/2022\/8566044","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T23:50:08Z","timestamp":1644364208000},"page":"1-8","source":"Crossref","is-referenced-by-count":10,"title":["MicroPulse Transscleral Laser Therapy Demonstrates Similar Efficacy with a Superior and More Favorable Safety Profile Compared to Continuous-Wave Transscleral Cyclophotocoagulation"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8082-4813","authenticated-orcid":true,"given":"Enrico","family":"Bernardi","sequence":"first","affiliation":[{"name":"University of Zurich, Medical Faculty, Zurich, Switzerland"},{"name":"University Hospital Zurich, Department of Ophthalmology, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2134-1336","authenticated-orcid":true,"given":"Marc","family":"T\u00f6teberg-Harms","sequence":"additional","affiliation":[{"name":"University of Zurich, Medical Faculty, Zurich, Switzerland"},{"name":"University Hospital Zurich, Department of Ophthalmology, Zurich, Switzerland"},{"name":"Department of Ophthalmology, Medical College of Georgia at Augusta University, Augusta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2012.02773.x"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1097\/01.APO.0000605096.48529.9c"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.53049"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s00347-015-0140-5"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31469-1"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-018-4011-z"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.05.013"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(17)30393-5"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.081224"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.mjafi.2015.12.001"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.pop.2015.05.008"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.3192"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000551"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-52052-5"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.50020"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a017236"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000740"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjo.2016.07.013"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-105271"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.2020.0225"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1055\/a-0577-7925"},{"key":"22","article-title":"Diode laser cyclophotocoagulation. 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