{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:26:36Z","timestamp":1767165996949,"version":"build-2238731810"},"reference-count":14,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T00:00:00Z","timestamp":1656460800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017702","name":"Innovation and Entrepreneurship Talent Project of Lanzhou","doi-asserted-by":"publisher","award":["2021-RC-139"],"award-info":[{"award-number":["2021-RC-139"]}],"id":[{"id":"10.13039\/501100017702","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017702","name":"Innovation and Entrepreneurship Talent Project of Lanzhou","doi-asserted-by":"publisher","award":["GSWSKY2021-001"],"award-info":[{"award-number":["GSWSKY2021-001"]}],"id":[{"id":"10.13039\/501100017702","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Health Industry Scientific Research Project of Gansu Province","award":["2021-RC-139"],"award-info":[{"award-number":["2021-RC-139"]}]},{"name":"Health Industry Scientific Research Project of Gansu Province","award":["GSWSKY2021-001"],"award-info":[{"award-number":["GSWSKY2021-001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,6,29]]},"abstract":"<jats:p>\n                    Objective. The aim of this study is to investigate the instruction value of the serum cystatin C (Cys C) level monitoring for intervention opportunity of continuous blood purification technology (CBP) in children with severe sepsis. Methods. 67 children with severe sepsis in the pediatric intensive care unit (PICU) with CBP treatment were retrospectively selected from May 2016 to April 2020. According to the time intervals between the time point of serum Cys C level began to increase (&gt;15\u2009mg\/L) and the time point of CBP began, all children were divided into group A (&lt;24\u2009h, 29 cases), group B (24\u201348\u2009h, 22 cases), and group C (&gt;48\u2009h, 16 cases). The children\u2019s general characteristics, vital signs, biochemical parameters, acute physiology and chronic health evaluation (APACHE II), and sequential organ failure assessment (SOFA) scores were evaluated. The influence factors of prognosis of children with severe sepsis were analyzed by multivariate regression analysis. Results. The intervals between the time point of PICU hospitalization and the time point of CBP began and the times of CBP in group A were significantly more than those in group B and C\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mfenced open=\"(\" close=\")\" separators=\"|\">\n                          <a:mrow>\n                            <a:mi>P<\/a:mi>\n                            <a:mo>&lt;<\/a:mo>\n                            <a:mn>0.05<\/a:mn>\n                          <\/a:mrow>\n                        <\/a:mfenced>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    . There was no statistically significant duration of CBP among three groups\n                    <jats:inline-formula>\n                      <f:math xmlns:f=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <f:mfenced open=\"(\" close=\")\" separators=\"|\">\n                          <f:mrow>\n                            <f:mi>P<\/f:mi>\n                            <f:mo>&gt;<\/f:mo>\n                            <f:mn>0.05<\/f:mn>\n                          <\/f:mrow>\n                        <\/f:mfenced>\n                      <\/f:math>\n                    <\/jats:inline-formula>\n                    . After follow-up of 28\u2009d, there was no significant difference on the occurrence of coagulation disorders and hypovolemic shock induced by CBP among three groups\n                    <jats:inline-formula>\n                      <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <k:mfenced open=\"(\" close=\")\" separators=\"|\">\n                          <k:mrow>\n                            <k:mi>P<\/k:mi>\n                            <k:mo>&gt;<\/k:mo>\n                            <k:mn>0.05<\/k:mn>\n                          <\/k:mrow>\n                        <\/k:mfenced>\n                      <\/k:math>\n                    <\/jats:inline-formula>\n                    . However, the mortality of children in group A was lower than that in group C\n                    <jats:inline-formula>\n                      <p:math xmlns:p=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <p:mfenced open=\"(\" close=\")\" separators=\"|\">\n                          <p:mrow>\n                            <p:mi>P<\/p:mi>\n                            <p:mo>&lt;<\/p:mo>\n                            <p:mn>0.05<\/p:mn>\n                          <\/p:mrow>\n                        <\/p:mfenced>\n                      <\/p:math>\n                    <\/jats:inline-formula>\n                    . Children in group A had lower APACHE II scores, SOFA scores, serum K+, blood urea nitrogen (BUN), serum creatine (SCr), partial pressure of carbon dioxide (PCO2), and higher partial pressure of oxygen (PO2) than those of children in group C after CBP.\n                    <jats:inline-formula>\n                      <u:math xmlns:u=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <u:mfenced open=\"(\" close=\")\" separators=\"|\">\n                          <u:mrow>\n                            <u:mi>P<\/u:mi>\n                            <u:mo>&lt;<\/u:mo>\n                            <u:mn>0.05<\/u:mn>\n                          <\/u:mrow>\n                        <\/u:mfenced>\n                      <\/u:math>\n                    <\/jats:inline-formula>\n                    . SOFA scores \u22655 after CBP treatment and the time intervals between the time point of serum Cys C level began to increase (&gt;15\u2009mg\/L) and the time point of CBP began \u226524\u2009h were the independent influence factors on the prognosis by multivariate regression analysis. Conclusion. There are significant evidences that continuous blood purification technology within 24\u2009h of serum Cys C level may better control the condition of children with severe sepsis.\n                  <\/jats:p>","DOI":"10.1155\/2022\/8571203","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T19:36:12Z","timestamp":1656531372000},"page":"1-6","source":"Crossref","is-referenced-by-count":1,"title":["Serum Cystatin C Level Monitoring for Intervention Opportunity of CBP in Children with Severe Sepsis"],"prefix":"10.1155","volume":"2022","author":[{"given":"Weikai","family":"Wang","sequence":"first","affiliation":[{"name":"Department of PICU, Gansu Provincial Maternity and Child-Care Hospital, The First Clinical Medical College of Gansu University of Chinese Medicine, Lanzhou 730050, Gansu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Qiang","sequence":"additional","affiliation":[{"name":"Cardiovascular Diseases Center, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou 730050, Gansu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongbin","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of PICU, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baowang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of PICU, The Second Hospital of Lanzhou University, Lanzhou 730030, Gansu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of PICU, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou 730050, Gansu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xilong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of PICU, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou 730050, Gansu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3820-9550","authenticated-orcid":true,"given":"Ruifeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of PICU, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou 730050, Gansu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-021-01829-4"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-021-01696-z"},{"issue":"2","key":"3","first-page":"389","article-title":"Continuous blood purification in children with severe sepsis","volume":"31","author":"X. H. Guo","year":"2017","journal-title":"Journal of Biological Regulators and Homeostatic Agents"},{"issue":"6","key":"4","first-page":"436","article-title":"Clinical review: extracorporeal blood purification in severe sepsis","volume":"31","author":"R. Venkataraman","year":"2017","journal-title":"Critical Care"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-015-9153-9"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2017.58.3.604"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.26689\/jcnr.v5i3.1999"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpa.2017.10.001"},{"issue":"2","key":"9","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3109\/00365513.2015.1126854","article-title":"Can admission serum cystatin C level be an early marker subclinical acute kidney injury in critical care patients","volume":"76","author":"\u00dc Gayg\u0131s\u0131z","year":"2016","journal-title":"Scandinavian Journal of Clinical and Laboratory Investigation"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.4103\/1319-2442.160170"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.34172\/npj.2021.09"},{"issue":"6","key":"12","first-page":"923","article-title":"Significance of serum and urine NGAL,KIM-1 levels in the diagnosis of urinary system disease-induced acute kidney injury in children","volume":"24","author":"L. Hou","year":"2013","journal-title":"Journal of China Medical University"},{"issue":"10","key":"13","doi-asserted-by":"crossref","first-page":"613","DOI":"10.4103\/0972-5229.167044","article-title":"Continuous renal replacement therapy in children with severe sepsis and multiorgan dysfunction - a pilot study on timing of initiation","volume":"19","author":"K. M. Gulla","year":"2015","journal-title":"Indian Journal of Critical Care Medicine"},{"issue":"2","key":"14","first-page":"389","article-title":"Continuous blood purification in children with severe sepsis","volume":"31","author":"X. H. Guo","year":"2017","journal-title":"Journal of Biological Regulators and Homeostatic Agents"}],"updated-by":[{"DOI":"10.1155\/2023\/9843515","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T00:00:00Z","timestamp":1689724800000},"record-id":"48543"},{"DOI":"10.1155\/2023\/9843515","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T00:00:00Z","timestamp":1689724800000}}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/8571203.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/8571203.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/8571203.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T19:36:25Z","timestamp":1656531385000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ecam\/2022\/8571203\/"}},"subtitle":[],"editor":[{"given":"Weiguo","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,6,29]]},"references-count":14,"alternative-id":["8571203","8571203"],"URL":"https:\/\/doi.org\/10.1155\/2022\/8571203","relation":{},"ISSN":["1741-4288","1741-427X"],"issn-type":[{"value":"1741-4288","type":"electronic"},{"value":"1741-427X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6,29]]}}}