{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T02:10:48Z","timestamp":1772590248652,"version":"3.50.1"},"reference-count":65,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,4,16]],"date-time":"2022-04-16T00:00:00Z","timestamp":1650067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical Health Science and Technology Project of Zhejiang Provincial Health Commission","award":["2019KY478"],"award-info":[{"award-number":["2019KY478"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2022,4,16]]},"abstract":"<jats:p>Background. Septic shock (SS) is the most common severe syndrome in the Intensive Care Unit (ICU). Enhancing the monitoring of hemodynamic indexes in SS patients carries huge clinical implications for reducing patient mortality. Recently, pulse indicator continuous cardiac output (PICCO) has been widely used in clinical practice, but its advantages than central venous pressure (CVP) in guiding the treatment of SS patients remains to be refined. Therefore, this study is aimed at assessing the clinical effects of PICCO in the treatment of patients with SS. Methods. The authors systematically searched several databases (PubMed, EMBASE, Cochrane Library, and China National Knowledge) between January 2001 and February 2021. When searching for relevant articles, the authors combined the following phrases describing the monitoring group (\u201cpulse indicator continuous cardiac output,\u201d \u201ccentral venous pressure\u201d) with the disease of interest as well as management (\u201cSS,\u201d \u201csepsis\u201d). The outcomes were independently assessed by two reviewers who scored the articles for methodological quality using the Cochrane Collaboration\u2019s \u201crisk of bias\u201d tool. Forest plots, as well as sensitivity and bias analyses, were carried out for the included articles. The primary outcome measures were length of ICU stay, duration of mechanical ventilation, 28-day mortality, and fluid resuscitation volume. Results. Ten studies comprising 350 cases monitored with PICCO and 373 cases monitored with traditional CVP were eventually identified. PICCO-monitored patients were observed to be significantly associated with shorter ICU stay than CVP-monitored patients (MD: \u22123.04, 95% CI: \u22124.74 to \u22121.34,<jats:inline-formula><a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><a:mi>P<\/a:mi><a:mo>=<\/a:mo><a:mn>0.0005<\/a:mn><\/a:math><\/jats:inline-formula>), shorter time of mechanical ventilation (MD: \u22121.84, 95% CI: \u22122.80 to \u22120.87,<jats:inline-formula><c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><c:mi>P<\/c:mi><c:mo>=<\/c:mo><c:mn>0.0002<\/c:mn><\/c:math><\/jats:inline-formula>), and lower 28-day mortality (RR: 0.67, 95% CI: 0.48 to 0.94,<jats:inline-formula><e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><e:mi>P<\/e:mi><e:mo>=<\/e:mo><e:mn>0.02<\/e:mn><\/e:math><\/jats:inline-formula>). The two groups showed no significant difference in subgroup analysis for fluid resuscitation volumes (<jats:inline-formula><g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><g:mi>P<\/g:mi><g:mo>&gt;<\/g:mo><g:mn>0.05<\/g:mn><\/g:math><\/jats:inline-formula>). Conclusion. PICCO monitoring technique can significantly improve the prognosis of SS patients, shorten the time of mechanical ventilation and ICU stay, and reduce the 28-day mortality, which has positive guiding significance for patients with SS. Given the limitations of the quantity and quality of included studies, further research is warranted to verify the conclusions.<\/jats:p>","DOI":"10.1155\/2022\/8604322","type":"journal-article","created":{"date-parts":[[2022,4,16]],"date-time":"2022-04-16T15:05:10Z","timestamp":1650121510000},"page":"1-9","source":"Crossref","is-referenced-by-count":6,"title":["Effect of Pulse Indicator Continuous Cardiac Output Monitoring on Septic Shock Patients: A Meta-Analysis"],"prefix":"10.1155","volume":"2022","author":[{"given":"Bin","family":"Wang","sequence":"first","affiliation":[{"name":"Emergency Department, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou City, 310000 Zhejiang Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijuan","family":"Cai","sequence":"additional","affiliation":[{"name":"Emergency Department, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou City, 310000 Zhejiang Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Lin","sequence":"additional","affiliation":[{"name":"Emergency Department, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou City, 310000 Zhejiang Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiongxiao","family":"He","sequence":"additional","affiliation":[{"name":"Emergency Department, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou City, 310000 Zhejiang Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9272-1806","authenticated-orcid":true,"given":"Xuejun","family":"Ding","sequence":"additional","affiliation":[{"name":"Emergency Department, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou City, 310000 Zhejiang Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1406745"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.124.5.1900"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-113-3-227"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1305727"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2009.08.004"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.2095-4352.2014.09.001"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-018-1059-1"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-014-3638-4"},{"issue":"10","key":"9","first-page":"855","article-title":"The application of combined central venous pressure and oxygen metabolism parameters monitoring in diagnosing septic shock-induced left ventricular dysfunction","volume":"54","author":"K. Cui","year":"2015","journal-title":"Zhonghua Nei Ke Za Zhi"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1053\/j.tcam.2016.08.009"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1186\/s40560-014-0058-z"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-2104"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2019.02.041"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.2095-4352.2014.09.009"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2014.07.017"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2020.3020358"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2014.11.057"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X1204000304"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000008111"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.2095-4352.2016.02.011"},{"issue":"15","key":"21","first-page":"1012","article-title":"Left ventricular-arterial coupling in the resuscitation of refractory septic shock","volume":"92","author":"S. W. Li","year":"2012","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1177\/1129729818820206"},{"issue":"9","key":"23","first-page":"693","article-title":"Pulse indicator continuous cardiac output measurement-guided treatment aids two pediatric patients with severe acute pancreatitis complicated with acute respiratory distress syndrome","volume":"52","author":"W. Yan","year":"2014","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.2095-4352.2017.01.009"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-9356(08)70516-4"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2016.3040"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2015.04.031"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.2095-4352.2017.06.002"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2015.06.006"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn121430-20200717-00529"},{"issue":"3","key":"32","doi-asserted-by":"crossref","first-page":"483","DOI":"10.3760\/cma.j.issn.0366-6999.20131830","article-title":"Effect of two volume responsiveness evaluation methods on fluid resuscitation and prognosis in septic shock patients","volume":"127","author":"Q. Xu","year":"2014","journal-title":"Chinese Medical Journal"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1378\/chest.121.4.1329"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-2732-y"},{"issue":"2","key":"35","first-page":"77","article-title":"Correlation of blood gas parameters with central venous pressure in patients with septic shock; a pilot study","volume":"2","author":"A. Baratloo","year":"2014","journal-title":"Bulletin of Emergency & Trauma"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2012.07.021"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2014.02.011"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1186\/cc13709"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0288"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31823778ee"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa010307"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.2095-4352.2017.12.003"},{"issue":"8","key":"43","first-page":"463","article-title":"An evaluation of stroke volume variation as a predictor of fluid responsiveness in mechanically ventilated elderly patients with severe sepsis","volume":"21","author":"Y. H. Yu","year":"2009","journal-title":"Zhongguo Wei Zhong Bing Ji Jiu Yi Xue"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2020.03.078"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-014-0496-y"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0289"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.5114\/ait.2019.87330"},{"key":"48","first-page":"496","article-title":"Efficacies of fluid resuscitation as guided by lactate clearance rate and central venous oxygen saturation in patients with septic shock","volume":"95","author":"X. Lyu","year":"2015","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2016.10.015"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000627"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-020-0803-y"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-14-32"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1007\/s10877-015-9749-9"},{"issue":"3","key":"54","first-page":"27","article-title":"The application of early goal directed therapy in patients during burn shock stage","volume":"7","author":"Z. H. Chen","year":"2017","journal-title":"International Journal of Burns and Trauma"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/519080"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v7.i11.1291"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-021-05889-z"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-58910-x"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000445"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1097\/00003643-200408000-00008"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-0087"},{"issue":"3","key":"62","first-page":"210","article-title":"Early identification and treatment of cardiovascular failure in severe sepsis","volume":"172","author":"N. Haase","year":"2010","journal-title":"Ugeskrift for Laeger"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1007\/s10877-015-9672-0"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.2095-4352.2015.01.006"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2011.12.036"}],"container-title":["Computational and Mathematical Methods in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2022\/8604322.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2022\/8604322.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2022\/8604322.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,22]],"date-time":"2024-09-22T10:01:00Z","timestamp":1726999260000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cmmm\/2022\/8604322\/"}},"subtitle":[],"editor":[{"given":"Xiucai","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,4,16]]},"references-count":65,"alternative-id":["8604322","8604322"],"URL":"https:\/\/doi.org\/10.1155\/2022\/8604322","relation":{},"ISSN":["1748-6718","1748-670X"],"issn-type":[{"value":"1748-6718","type":"electronic"},{"value":"1748-670X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4,16]]}}}