{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T02:57:29Z","timestamp":1776567449810,"version":"3.51.2"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,1,15]],"date-time":"2022-01-15T00:00:00Z","timestamp":1642204800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770976"],"award-info":[{"award-number":["81770976"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2022,1,15]]},"abstract":"<jats:p>Background. The Chinese subtype of CRSwNP may have a unique pathogenesis. This study was designed to seek the role of the PI3K\/Akt\/HIF-1\u03b1 pathway and IL-17A in CRSwNP. Methods. The total IgE, ECP, and IL-17A levels were determined by UniCAP100 and ELISA. The activity of MPO was detected by the biochemical techniques. The protein expressions of HIF-1\u03b1, p-Akt, and PI3K were detected by the WB method. HIF-1\u03b1 and IL-17A mRNA levels were measured by RT-PCR. Results. The CRSwNP group showed significantly elevated MPO activity, PI3K, p-AKT protein, HIF-1\u03b1, and IL-17A mRNA levels in nasal polyps. Stimulated by the TNF-\u03b1, the PI3K, p-AKT, HIF-1\u03b1, and IL-17A levels significantly elevated in the fibroblasts. Inhibited by the Wortmannin, those indicators significantly declined in the fibroblasts. Conclusion. The PI3K\/Akt\/HIF-1\u03b1 pathway played a role in the pathogenesis of CRSwNP. The elevated IL-17A level might be responsible for the neutrophilic inflammation in CRSwNP. The PI3K\/Akt\/HIF-1\u03b1 pathway might regulate the IL-17A-related inflammation in CRSwNP.<\/jats:p>","DOI":"10.1155\/2022\/8609590","type":"journal-article","created":{"date-parts":[[2022,1,15]],"date-time":"2022-01-15T23:20:08Z","timestamp":1642288808000},"page":"1-10","source":"Crossref","is-referenced-by-count":12,"title":["Roles Played by the PI3K\/Akt\/HIF-1\u03b1 Pathway and IL-17A in the Chinese Subtype of Chronic Sinusitis with Nasal Polyps"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5078-1448","authenticated-orcid":true,"given":"Ke-Jia","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9254-1389","authenticated-orcid":true,"given":"Min-Li","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3680-3975","authenticated-orcid":true,"given":"Yong-Cai","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7163-2289","authenticated-orcid":true,"given":"Shui-Hong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011992.pub2"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2010.11.010"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-015-3858-x"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.08.123"},{"key":"5","first-page":"1","article-title":"European position paper on rhinosinusitis and nasal polyps 2012","volume":"23","author":"W. 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