{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T18:53:30Z","timestamp":1771268010813,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T00:00:00Z","timestamp":1651881600000},"content-version":"vor","delay-in-days":126,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Epitech Group SpA"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Palmitoylethanolamide is reported to solve pain and neuroinflammation in different models of chronic and neurodegenerative diseases. Some concerns have been illustrated for cautiously interpreting the available literature on the topic. Specifically, there is a lack of evidence about palmitoylethanolamide and female chronic pelvic pain. Concerns will be best solved by randomized trials. The present study was aimed at finding the best responders to micronized palmitoylethanolamide in female patient with chronic pelvic pain, using the existing literature at individual patient level, to help further randomized trial planning. <jats:italic>Methods<\/jats:italic>. After a systematic research, eligible studies (the ones enrolled female patients treated for chronic pelvic pain or for dyspareunia, dysuria, dyschezia, and dysmenorrhea with or without chronic pelvic pain) were assessed at individual patient data level. Conditional probabilities were calculated to assess variables conditioning the rates of good responders (pain score points more or equal to 3 reduction), poor responders (2 pain score reduction), and nonresponders at a three\u2010month follow\u2010up. <jats:italic>Results<\/jats:italic>. Only cases treated with palmitoylethanolamide comicronized with polydatin for a short period can be assessed. Good responders are more than 50%. In chronic pelvic pain, there is a 19.0% conditional probability to find good responders among patients with pain score at enrolment of 6 to 8 and of 6.8% to find poor responders among patients with a pain score at enrolment of 6 to 8. Painful disease does not matter on responders\u2019 rates. <jats:italic>Conclusion<\/jats:italic>. Best responders to comicronized palmitoylethanolamide\/polydatin are patients with pain score higher than 6 at enrolment, irrespective of other variables.<\/jats:p>","DOI":"10.1155\/2022\/8620077","type":"journal-article","created":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T16:35:05Z","timestamp":1651941305000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Looking for Responders among Women with Chronic Pelvic Pain Treated with a Comicronized Formulation of Micronized Palmitoylethanolamide and Polydatin"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7660-6864","authenticated-orcid":false,"given":"Ugo","family":"Indraccolo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Favilli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arianna","family":"Dell\u2019Anna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Di Francesco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Dionisi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Giugliano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filippo","family":"Murina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erica","family":"Stocco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,7]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6446(05)03637-8"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-071719-094903"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3690"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2010.12.014"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12170"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.4172\/Neuropsychiatry.1000549"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21155330"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21217942"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13020"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13580"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci7020078"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00821"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2014.05.006"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22105305"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-013-0191-7"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-014-0136-0"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00249"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.36076\/ppj\/2016.19.11"},{"key":"e_1_2_9_19_2","first-page":"125","article-title":"Micronized palmitoylethanolamide\/trans-polydatin treatment of endometriosis-related pain: a meta-analysis","volume":"53","author":"Indraccolo U.","year":"2017","journal-title":"Annali Dell'istituto Superiore Di Sanita"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2010.01.008"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00382"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.11138\/giog\/2014.36.2.353"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9828397"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10030464"},{"key":"e_1_2_9_25_2","article-title":"Dietary supplements: regulatory challenges and research resources","volume":"10","author":"Dweyer J. 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