{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T11:23:22Z","timestamp":1762341802921,"version":"3.37.3"},"reference-count":54,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T00:00:00Z","timestamp":1641340800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"First People\u2019s Hospital of Chenzhou City","award":["N2019-006","2019YJGL04","ZDYF-20200092"],"award-info":[{"award-number":["N2019-006","2019YJGL04","ZDYF-20200092"]}]},{"DOI":"10.13039\/501100009020","name":"University of South China","doi-asserted-by":"publisher","award":["N2019-006","2019YJGL04","ZDYF-20200092"],"award-info":[{"award-number":["N2019-006","2019YJGL04","ZDYF-20200092"]}],"id":[{"id":"10.13039\/501100009020","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chenzhou Science and Technology Bureau","award":["N2019-006","2019YJGL04","ZDYF-20200092"],"award-info":[{"award-number":["N2019-006","2019YJGL04","ZDYF-20200092"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2022,1,5]]},"abstract":"<jats:p>Background. Dry eye is a multifactor disease which needs comprehensive treatments to keep the homeostasis of ocular surface. Objective. To explore the effect of hypochlorous acid on the meibomian gland dysfunction dry eye through ultrasonic atomization. Methods. We set this study of 0.01% HOCL and 0.1% hyaluronate by ultrasonic atomization. All the data was recorded at the 1st, 15th, 30th, and 55th days. The patients\u2019 complains, the meibum analysis, conjunctive congestion, corneal staining, Schirmer\u2019s I test, and NIBUT were recorded by K5M, the MMP-9, and IL-2 of tear by inflammation kit; the Demodex was recorded by microscopy. Results. 53 patients have joined this study. There is no statistic difference between them on OSDI (day 15: <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.061<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>, 30: <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.055<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>, 55: <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>p<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>0.052<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>); results show the <jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mn>10.57<\/g:mn>\n                        <g:mo>\u00b1<\/g:mo>\n                        <g:mn>0.13<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula> and <jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mn>12.54<\/i:mn>\n                        <i:mo>\u00b1<\/i:mo>\n                        <i:mn>0.17<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula> reduction on OSDI; the differences of both treatments are significant (<jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:msup>\n                           <k:mrow\/>\n                           <k:mrow>\n                              <k:mo>\u2217<\/k:mo>\n                              <k:mrow>\n                                 <k:mo>\u2217<\/k:mo>\n                              <\/k:mrow>\n                           <\/k:mrow>\n                        <\/k:msup>\n                        <k:mi>p<\/k:mi>\n                        <k:mo>&lt;<\/k:mo>\n                        <k:mn>0.01<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula>). Increased Schirmer\u2019s and TBUT are <jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mn>3.27<\/m:mn>\n                        <m:mo>\u00b1<\/m:mo>\n                        <m:mn>0.10<\/m:mn>\n                     <\/m:math>\n                  <\/jats:inline-formula> and <jats:inline-formula>\n                     <o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                        <o:mn>6.29<\/o:mn>\n                        <o:mo>\u00b1<\/o:mo>\n                        <o:mn>0.10<\/o:mn>\n                     <\/o:math>\n                  <\/jats:inline-formula> (<jats:inline-formula>\n                     <q:math xmlns:q=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\">\n                        <q:msup>\n                           <q:mrow\/>\n                           <q:mrow>\n                              <q:mo>\u2217<\/q:mo>\n                              <q:mrow>\n                                 <q:mo>\u2217<\/q:mo>\n                              <\/q:mrow>\n                           <\/q:mrow>\n                        <\/q:msup>\n                        <q:mi>p<\/q:mi>\n                        <q:mo>&lt;<\/q:mo>\n                        <q:mn>0.01<\/q:mn>\n                     <\/q:math>\n                  <\/jats:inline-formula>) or <jats:inline-formula>\n                     <s:math xmlns:s=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\">\n                        <s:mn>7.32<\/s:mn>\n                        <s:mo>\u00b1<\/s:mo>\n                        <s:mn>1.72<\/s:mn>\n                     <\/s:math>\n                  <\/jats:inline-formula>\u2009s and <jats:inline-formula>\n                     <u:math xmlns:u=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\">\n                        <u:mn>9.22<\/u:mn>\n                        <u:mo>\u00b1<\/u:mo>\n                        <u:mn>1.41<\/u:mn>\n                     <\/u:math>\n                  <\/jats:inline-formula>\u2009s (<jats:inline-formula>\n                     <w:math xmlns:w=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M12\">\n                        <w:msup>\n                           <w:mrow\/>\n                           <w:mrow>\n                              <w:mo>\u2217<\/w:mo>\n                           <\/w:mrow>\n                        <\/w:msup>\n                        <w:mi>p<\/w:mi>\n                        <w:mo>&lt;<\/w:mo>\n                        <w:mn>0.05<\/w:mn>\n                     <\/w:math>\n                  <\/jats:inline-formula>); the decreased conjunctive and corneal staining are <jats:inline-formula>\n                     <y:math xmlns:y=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M13\">\n                        <y:mn>0.23<\/y:mn>\n                        <y:mo>\u00b1<\/y:mo>\n                        <y:mn>0.07<\/y:mn>\n                     <\/y:math>\n                  <\/jats:inline-formula> and <jats:inline-formula>\n                     <ab:math xmlns:ab=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M14\">\n                        <ab:mn>0.45<\/ab:mn>\n                        <ab:mo>\u00b1<\/ab:mo>\n                        <ab:mn>0.06<\/ab:mn>\n                     <\/ab:math>\n                  <\/jats:inline-formula> (<jats:inline-formula>\n                     <cb:math xmlns:cb=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M15\">\n                        <cb:msup>\n                           <cb:mrow\/>\n                           <cb:mrow>\n                              <cb:mo>\u2217<\/cb:mo>\n                              <cb:mrow>\n                                 <cb:mo>\u2217<\/cb:mo>\n                              <\/cb:mrow>\n                           <\/cb:mrow>\n                        <\/cb:msup>\n                        <cb:mi>p<\/cb:mi>\n                        <cb:mo>&lt;<\/cb:mo>\n                        <cb:mn>0.01<\/cb:mn>\n                     <\/cb:math>\n                  <\/jats:inline-formula>) or <jats:inline-formula>\n                     <eb:math xmlns:eb=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M16\">\n                        <eb:mn>0.42<\/eb:mn>\n                        <eb:mo>\u00b1<\/eb:mo>\n                        <eb:mn>0.03<\/eb:mn>\n                     <\/eb:math>\n                  <\/jats:inline-formula> and <jats:inline-formula>\n                     <gb:math xmlns:gb=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M17\">\n                        <gb:mn>0.37<\/gb:mn>\n                        <gb:mo>\u00b1<\/gb:mo>\n                        <gb:mn>0.02<\/gb:mn>\n                     <\/gb:math>\n                  <\/jats:inline-formula> (<jats:inline-formula>\n                     <ib:math xmlns:ib=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M18\">\n                        <ib:msup>\n                           <ib:mrow\/>\n                           <ib:mrow>\n                              <ib:mo>\u2217<\/ib:mo>\n                           <\/ib:mrow>\n                        <\/ib:msup>\n                        <ib:mi>p<\/ib:mi>\n                        <ib:mo>&lt;<\/ib:mo>\n                        <ib:mn>0.05<\/ib:mn>\n                     <\/ib:math>\n                  <\/jats:inline-formula>) at both groups. The differences of MMP-9 and IL-2 negative rate are significant (<jats:inline-formula>\n                     <kb:math xmlns:kb=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M19\">\n                        <kb:mi>Z<\/kb:mi>\n                        <kb:mo>=<\/kb:mo>\n                        <kb:mn>0.896<\/kb:mn>\n                     <\/kb:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <mb:math xmlns:mb=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M20\">\n                        <mb:msup>\n                           <mb:mrow\/>\n                           <mb:mrow>\n                              <mb:mo>\u2217<\/mb:mo>\n                              <mb:mrow>\n                                 <mb:mo>\u2217<\/mb:mo>\n                              <\/mb:mrow>\n                           <\/mb:mrow>\n                        <\/mb:msup>\n                        <mb:mi>p<\/mb:mi>\n                        <mb:mo>=<\/mb:mo>\n                        <mb:mn>0.002<\/mb:mn>\n                        <mb:mo>&lt;<\/mb:mo>\n                        <mb:mn>0.01<\/mb:mn>\n                     <\/mb:math>\n                  <\/jats:inline-formula>; <jats:inline-formula>\n                     <ob:math xmlns:ob=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M21\">\n                        <ob:mi>Z<\/ob:mi>\n                        <ob:mo>=<\/ob:mo>\n                        <ob:mn>0.659<\/ob:mn>\n                     <\/ob:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <qb:math xmlns:qb=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M22\">\n                        <qb:msup>\n                           <qb:mrow\/>\n                           <qb:mrow>\n                              <qb:mo>\u2217<\/qb:mo>\n                              <qb:mrow>\n                                 <qb:mo>\u2217<\/qb:mo>\n                              <\/qb:mrow>\n                           <\/qb:mrow>\n                        <\/qb:msup>\n                        <qb:mi>p<\/qb:mi>\n                        <qb:mo>=<\/qb:mo>\n                        <qb:mn>0.001<\/qb:mn>\n                        <qb:mo>&lt;<\/qb:mo>\n                        <qb:mn>0.01<\/qb:mn>\n                     <\/qb:math>\n                  <\/jats:inline-formula>); the number of Demodex mites at first is 10 or 11, while the last is 2 or 6 (<jats:inline-formula>\n                     <sb:math xmlns:sb=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M23\">\n                        <sb:mi>Z<\/sb:mi>\n                        <sb:mo>=<\/sb:mo>\n                        <sb:mo>\u2212<\/sb:mo>\n                        <sb:mn>4.642<\/sb:mn>\n                     <\/sb:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <ub:math xmlns:ub=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M24\">\n                        <ub:msup>\n                           <ub:mrow\/>\n                           <ub:mrow>\n                              <ub:mo>\u2217<\/ub:mo>\n                              <ub:mrow>\n                                 <ub:mo>\u2217<\/ub:mo>\n                              <\/ub:mrow>\n                           <\/ub:mrow>\n                        <\/ub:msup>\n                        <ub:mi>p<\/ub:mi>\n                        <ub:mo>&lt;<\/ub:mo>\n                        <ub:mn>0.01<\/ub:mn>\n                     <\/ub:math>\n                  <\/jats:inline-formula>; <jats:inline-formula>\n                     <wb:math xmlns:wb=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M25\">\n                        <wb:mi>Z<\/wb:mi>\n                        <wb:mo>=<\/wb:mo>\n                        <wb:mn>2.742<\/wb:mn>\n                     <\/wb:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <yb:math xmlns:yb=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M26\">\n                        <yb:mi>p<\/yb:mi>\n                        <yb:mo>&gt;<\/yb:mo>\n                        <yb:mn>0.05<\/yb:mn>\n                     <\/yb:math>\n                  <\/jats:inline-formula>). The Demodex count between them is significant (<jats:inline-formula>\n                     <ac:math xmlns:ac=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M27\">\n                        <ac:mi>Z<\/ac:mi>\n                        <ac:mo>=<\/ac:mo>\n                        <ac:mo>\u2212<\/ac:mo>\n                        <ac:mn>2.310<\/ac:mn>\n                     <\/ac:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <cc:math xmlns:cc=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M28\">\n                        <cc:msup>\n                           <cc:mrow\/>\n                           <cc:mrow>\n                              <cc:mo>\u2217<\/cc:mo>\n                           <\/cc:mrow>\n                        <\/cc:msup>\n                        <cc:mi>p<\/cc:mi>\n                        <cc:mo>=<\/cc:mo>\n                        <cc:mn>0.032<\/cc:mn>\n                        <cc:mo>&lt;<\/cc:mo>\n                        <cc:mn>0.05<\/cc:mn>\n                     <\/cc:math>\n                  <\/jats:inline-formula>). The survival times (ST) of each stage at the HOCL are 110.75 (<jats:inline-formula>\n                     <ec:math xmlns:ec=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M29\">\n                        <ec:mn>108.50<\/ec:mn>\n                        <ec:mo>\u00b1<\/ec:mo>\n                        <ec:mn>24.50<\/ec:mn>\n                     <\/ec:math>\n                  <\/jats:inline-formula>), 95.50 (<jats:inline-formula>\n                     <gc:math xmlns:gc=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M30\">\n                        <gc:mn>90.25<\/gc:mn>\n                        <gc:mo>\u00b1<\/gc:mo>\n                        <gc:mn>14.50<\/gc:mn>\n                     <\/gc:math>\n                  <\/jats:inline-formula>), and 75.25 (<jats:inline-formula>\n                     <ic:math xmlns:ic=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M31\">\n                        <ic:mn>73.48<\/ic:mn>\n                        <ic:mo>\u00b1<\/ic:mo>\n                        <ic:mn>8.50<\/ic:mn>\n                     <\/ic:math>\n                  <\/jats:inline-formula>) min which are shorter than those of control which are 155.50 (<jats:inline-formula>\n                     <kc:math xmlns:kc=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M32\">\n                        <kc:mn>160.10<\/kc:mn>\n                        <kc:mo>\u00b1<\/kc:mo>\n                        <kc:mn>21.50<\/kc:mn>\n                     <\/kc:math>\n                  <\/jats:inline-formula>), 130.25 (<jats:inline-formula>\n                     <mc:math xmlns:mc=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M33\">\n                        <mc:mn>128.25<\/mc:mn>\n                        <mc:mo>\u00b1<\/mc:mo>\n                        <mc:mn>16.50<\/mc:mn>\n                     <\/mc:math>\n                  <\/jats:inline-formula>), and 105.75 (<jats:inline-formula>\n                     <oc:math xmlns:oc=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M34\">\n                        <oc:mn>102.50<\/oc:mn>\n                        <oc:mo>\u00b1<\/oc:mo>\n                        <oc:mn>14.50<\/oc:mn>\n                     <\/oc:math>\n                  <\/jats:inline-formula>) min (<jats:inline-formula>\n                     <qc:math xmlns:qc=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M35\">\n                        <qc:msup>\n                           <qc:mrow\/>\n                           <qc:mrow>\n                              <qc:mo>\u2217<\/qc:mo>\n                              <qc:mrow>\n                                 <qc:mo>\u2217<\/qc:mo>\n                              <\/qc:mrow>\n                           <\/qc:mrow>\n                        <\/qc:msup>\n                        <qc:mi>p<\/qc:mi>\n                        <qc:mo>&lt;<\/qc:mo>\n                        <qc:mn>0.01<\/qc:mn>\n                     <\/qc:math>\n                  <\/jats:inline-formula>). The Demodex eradication rate of HOCL is statistic significant (<jats:inline-formula>\n                     <sc:math xmlns:sc=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M36\">\n                        <sc:msup>\n                           <sc:mrow\/>\n                           <sc:mrow>\n                              <sc:mo>\u2217<\/sc:mo>\n                           <\/sc:mrow>\n                        <\/sc:msup>\n                        <sc:mi>p<\/sc:mi>\n                     <\/sc:math>\n                  <\/jats:inline-formula>15th vs. 1st<jats:inline-formula>\n                     <uc:math xmlns:uc=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M37\">\n                        <uc:mtext>day<\/uc:mtext>\n                        <uc:mo>=<\/uc:mo>\n                        <uc:mn>0.028<\/uc:mn>\n                        <uc:mo>&lt;<\/uc:mo>\n                        <uc:mn>0.05<\/uc:mn>\n                     <\/uc:math>\n                  <\/jats:inline-formula>; <jats:inline-formula>\n                     <wc:math xmlns:wc=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M38\">\n                        <wc:msup>\n                           <wc:mrow\/>\n                           <wc:mrow>\n                              <wc:mo>\u2217<\/wc:mo>\n                              <wc:mo>\u2217<\/wc:mo>\n                           <\/wc:mrow>\n                        <\/wc:msup>\n                        <wc:mi>p<\/wc:mi>\n                     <\/wc:math>\n                  <\/jats:inline-formula>30th vs. 1st<jats:inline-formula>\n                     <yc:math xmlns:yc=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M39\">\n                        <yc:mtext>day<\/yc:mtext>\n                        <yc:mo>=<\/yc:mo>\n                        <yc:mn>0.002<\/yc:mn>\n                        <yc:mo>&lt;<\/yc:mo>\n                        <yc:mn>0.01<\/yc:mn>\n                     <\/yc:math>\n                  <\/jats:inline-formula>; <jats:inline-formula>\n                     <ad:math xmlns:ad=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M40\">\n                        <ad:msup>\n                           <ad:mrow\/>\n                           <ad:mrow>\n                              <ad:mo>\u2217<\/ad:mo>\n                              <ad:mo>\u2217<\/ad:mo>\n                           <\/ad:mrow>\n                        <\/ad:msup>\n                        <ad:mi>p<\/ad:mi>\n                     <\/ad:math>\n                  <\/jats:inline-formula>55th vs. 1st<jats:inline-formula>\n                     <cd:math xmlns:cd=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M41\">\n                        <cd:mtext>day<\/cd:mtext>\n                        <cd:mo>=<\/cd:mo>\n                        <cd:mn>0.0018<\/cd:mn>\n                        <cd:mo>&lt;<\/cd:mo>\n                        <cd:mn>0.01<\/cd:mn>\n                     <\/cd:math>\n                  <\/jats:inline-formula>). Conclusions. 0.01% HOCL improves the Demodex eradication by shortening the survival time; the HOCL acts on the ocular surface by reducing the inflammation. The ultrasonic atomization helps for the drug usage.<\/jats:p>","DOI":"10.1155\/2022\/8631038","type":"journal-article","created":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T19:50:08Z","timestamp":1641412208000},"page":"1-12","source":"Crossref","is-referenced-by-count":5,"title":["Hypochlorous Acid Can Be the Novel Option for the Meibomian Gland Dysfunction Dry Eye through Ultrasonic Atomization"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1719-5337","authenticated-orcid":true,"given":"Zhiyuan","family":"Li","sequence":"first","affiliation":[{"name":"The Diagnosis and Treatment Technology Research and Development Centre for Dry Eye and Ocular Surface Disease of Chenzhou, Chenzhou, 423000 Hunan, China"},{"name":"The Ophthalmology Department of the Affiliated Chenzhou Hospital, Hengyan Medical School, University of South China, Chenzhou, 423000 Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyan","family":"Wang","sequence":"additional","affiliation":[{"name":"The Operation Department of the Affiliated Chenzhou Hospital, Hengyan Medical School, University of South China, Chenzhou, 423000 Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mo","family":"Liang","sequence":"additional","affiliation":[{"name":"The Diagnosis and Treatment Technology Research and Development Centre for Dry Eye and Ocular Surface Disease of Chenzhou, Chenzhou, 423000 Hunan, China"},{"name":"The Ophthalmology Department of the Affiliated Chenzhou Hospital, Hengyan Medical School, University of South China, Chenzhou, 423000 Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenghua","family":"Li","sequence":"additional","affiliation":[{"name":"The Diagnosis and Treatment Technology Research and Development Centre for Dry Eye and Ocular Surface Disease of Chenzhou, Chenzhou, 423000 Hunan, China"},{"name":"The Ophthalmology Department of the Affiliated Chenzhou Hospital, Hengyan Medical School, University of South China, Chenzhou, 423000 Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvliang","family":"Li","sequence":"additional","affiliation":[{"name":"The Diagnosis and Treatment Technology Research and Development Centre for Dry Eye and Ocular Surface Disease of Chenzhou, Chenzhou, 423000 Hunan, China"},{"name":"The Ophthalmology Department of the Affiliated Chenzhou Hospital, Hengyan Medical School, University of South China, Chenzhou, 423000 Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoping","family":"Zhou","sequence":"additional","affiliation":[{"name":"The Diagnosis and Treatment Technology Research and Development Centre for Dry Eye and Ocular Surface Disease of Chenzhou, Chenzhou, 423000 Hunan, China"},{"name":"The Ophthalmology Department of the Affiliated Chenzhou Hospital, Hengyan Medical School, University of South China, Chenzhou, 423000 Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoping","family":"Kuang","sequence":"additional","affiliation":[{"name":"The Diagnosis and Treatment Technology Research and Development Centre for Dry Eye and Ocular Surface Disease of Chenzhou, Chenzhou, 423000 Hunan, China"},{"name":"The Ophthalmology Department of the Affiliated Chenzhou Hospital, Hengyan Medical School, University of South China, Chenzhou, 423000 Hunan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2017.08.003"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2017.05.003"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.5114\/ceji.2019.87070"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0000000000000666"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-021-01926-2"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.18240\/ijo.2021.04.14"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2019.09.005"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcmed.2020.12.001"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0000000000000456"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26082276"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-020-03591-y"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26092485"},{"key":"13","first-page":"743","article-title":"Clinical observation of ultrasonic atomization of traditional Chinese medicine in treatment of dry eye in patients with type 2 diabetes mellitus","volume":"4","author":"Z. Haoyan","year":"2020","journal-title":"Clinical Journal of Traditional Chinese Medicine"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_2001_20"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.12.018"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.12993"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9124022"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.118.5.615"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2014-306453"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000001033"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14129"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.3980\/j.issn.2222-3959.2012.04.14"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199801000-00007"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.10.2.4"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6997a"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-021-01871-0"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0218886"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2018.06.002"},{"issue":"7","key":"29","first-page":"491","article-title":"Consensus of diagnosis and treatment experts on vermicoid mite blepharitis in China 2018","volume":"54","author":"Chinese branch of Asian dry eye association, ophthalmology group of ophthalmology committee of cross-strait medical exchange association","year":"2018","journal-title":"Chinese Journal of Ophthalmology"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-0275"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1080\/02713683.2018.1536217"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S132851"},{"key":"33","volume-title":"Designing Clinical Research: An Epidemiologic Approach","author":"S. B. Hulley","year":"2013","edition":"4th"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.3758\/BF03193146"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2019-315747"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.07.010"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-23651"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.2741\/4423"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2020.8030"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4534350"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajoc.2021.101171"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13280"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0000000000000415"},{"issue":"11","key":"44","first-page":"36","article-title":"Status report on topical hypochlorous acid: clinical relevance of specific formulations, potential modes of action, and study outcomes","volume":"11","author":"J. Q. Del Rosso","year":"2018","journal-title":"The Journal of Clinical and Aesthetic Dermatology"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-38968-y"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2017.10.012"},{"key":"47","first-page":"660","article-title":"Research progress in physical therapy for dry eye","volume":"18","author":"K. Ma","year":"2018","journal-title":"International Eye Science"},{"key":"48","first-page":"367","article-title":"Research progress of ultrasonic atomization treating dry eye","volume":"30","author":"J. C. Yuqiu Xu","year":"2020","journal-title":"Journal Traditional Chinese Medicine Ophthalmology"},{"key":"49","first-page":"45","article-title":"Clinical observation and analysis of dry eye after phacoemulsification and intraocular lens implantation with traditional Chinese medicine ultrasonic atomization","volume":"A01","author":"Y. Zhou","year":"2018","journal-title":"Hunan University of Chinese Medicine"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.9769"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1097\/01.ico.0000244870.62384.79"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.2.7.2"},{"volume-title":"Treatment of Demodex with hypochlorous acid: case report consistent treatment with hypochlorous acid may improve symptoms for symptomatic dry eye patients. Dry eye patients report improvement in symptoms with hypochlorous acid use over 30 days. This abstract was presented at the 2019 ARVO annual meeting","year":"2019","author":"E. Bitton","key":"53"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2012.27.12.1574"}],"container-title":["Disease Markers"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2022\/8631038.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2022\/8631038.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2022\/8631038.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T19:50:25Z","timestamp":1641412225000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/dm\/2022\/8631038\/"}},"subtitle":[],"editor":[{"given":"Ting","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,1,5]]},"references-count":54,"alternative-id":["8631038","8631038"],"URL":"https:\/\/doi.org\/10.1155\/2022\/8631038","relation":{},"ISSN":["1875-8630","0278-0240"],"issn-type":[{"type":"electronic","value":"1875-8630"},{"type":"print","value":"0278-0240"}],"subject":[],"published":{"date-parts":[[2022,1,5]]}}}