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Electroacupuncture effectively improves the symptoms of constipation in patients with PD. In the present study, we used thymus cell antigen 1-\u03b1-synuclein (Thy1-\u03b1Syn) transgenic mice as a model of intestinal motility disorders in PD to determine the therapeutic effect of electroacupuncture and the underlying mechanisms. Electroacupuncture significantly improved fecal excretion and accelerated the rate of small-intestinal propulsion in Thy1-\u03b1Syn mice by upregulating the serotonin concentration and the expression of the serotonin 4 receptor. Consequently, the downstream cyclic AMP\/protein kinase A (cAMP\/PKA) pathway was affected, and to upregulate and downregulate, the expression of substance <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                     <\/a:math>\n                  <\/jats:inline-formula> was upregulated, and the expression of calcitonin gene-related peptide was downregulated. In summary, electroacupuncture improved intestinal motility in PD mice by affecting serotonin levels, serotonin 4 receptor expression, and the cAMP\/PKA pathway, providing a potentially effective and promising complementary and alternative therapy for relieving constipation symptoms in patients with PD.<\/jats:p>","DOI":"10.1155\/2022\/8659462","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T20:35:08Z","timestamp":1666989308000},"page":"1-13","source":"Crossref","is-referenced-by-count":8,"title":["Electroacupuncture Modulates 5-HT4R-Mediated cAMP\/PKA Signaling to Improve Intestinal Motility Disorders in a Thy1-\u03b1Syn Parkinson\u2019s Mouse Model"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0724-6420","authenticated-orcid":true,"given":"Lin","family":"Shen","sequence":"first","affiliation":[{"name":"Shanghai Research Institute of Acupuncture and Meridian, Shanghai University of Traditional Chinese 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