{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:58:34Z","timestamp":1767167914356,"version":"build-2238731810"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T00:00:00Z","timestamp":1643414400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012326","name":"International Science and Technology Cooperation Programme","doi-asserted-by":"publisher","award":["2018KW-062"],"award-info":[{"award-number":["2018KW-062"]}],"id":[{"id":"10.13039\/501100012326","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012326","name":"International Science and Technology Cooperation Programme","doi-asserted-by":"publisher","award":["2019JM-133"],"award-info":[{"award-number":["2019JM-133"]}],"id":[{"id":"10.13039\/501100012326","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Basic Research Plan in Shanxi Province of China","award":["2018KW-062"],"award-info":[{"award-number":["2018KW-062"]}]},{"name":"Natural Science Basic Research Plan in Shanxi Province of China","award":["2019JM-133"],"award-info":[{"award-number":["2019JM-133"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2022,1,29]]},"abstract":"<jats:p>Swine pneumonia commonly known as swine pasteurellosis is an infectious disease of swine caused by Pasteurella multocida infection. It has been reported that Toll-like receptors (TLRs) play a vital role in swine pneumonia progression. However, the underlying mechanism has not been elucidated. This research was aimed at investigating the molecular mechanism by which TLR9 regulates swine pneumonia progression. Our findings illustrated that the HD-13 strain of Pasteurella multocida D (HD-13) accelerated TLR9 expression in porcine alveolar macrophage 3D4\/21 cells; HD-13 activated the inflammatory response via accelerating TLR9 expression. Mechanistically, HD-13 activated mitogen-activated protein kinase (MAPK) and nuclear factor kB (NF-\u03baB) signals. In conclusion, HD-13 may activate MAPK and NF-\u03baB pathways via accelerating TLR9 expression, thereby accelerating the inflammatory response in the progression of swine pneumonia. TLR9 may serve as a novel therapeutic target for swine pneumonia. Our research may provide a theoretical basis for the prevention and treatment of swine pneumonia.<\/jats:p>","DOI":"10.1155\/2022\/8660752","type":"journal-article","created":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T11:35:09Z","timestamp":1643456109000},"page":"1-11","source":"Crossref","is-referenced-by-count":2,"title":["HD-13 Induces Swine Pneumonia Progression via Activation of TLR9"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1613-6378","authenticated-orcid":true,"given":"Jing","family":"Liu","sequence":"first","affiliation":[{"name":"Jiangsu Agri-Animal Husbandry Vocational College, Taizhou, 225300 Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6270-5928","authenticated-orcid":true,"given":"Jiayi","family":"Xu","sequence":"additional","affiliation":[{"name":"Nanjing Agricultural University, Nanjing, 210095 Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2551-4641","authenticated-orcid":true,"given":"Honglei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Jiangsu Agri-Animal Husbandry Vocational College, Taizhou, 225300 Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2644-2897","authenticated-orcid":true,"given":"Lihua","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangsu Agri-Animal Husbandry Vocational College, Taizhou, 225300 Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2006.02.004"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cimid.2016.07.004"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(02)00462-0"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2007.07.011"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2019.07.017"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2020.103968"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2019.103911"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.vas.2018.100044"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.116671"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2020.01.019"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.7150\/thno.44417"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2019.115195"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.dci.2019.02.010"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1002\/arch.21423"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2005.08.001"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2009.10.001"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2020.108461"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-013-0727-4"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.05.042"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106473"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2020.108653"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a001651"}],"updated-by":[{"DOI":"10.1155\/2023\/9864707","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T00:00:00Z","timestamp":1689724800000},"record-id":"47905"},{"DOI":"10.1155\/2022\/9841070","type":"correction","label":"Correction","source":"retraction-watch","updated":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T00:00:00Z","timestamp":1668556800000},"record-id":"47906"},{"DOI":"10.1155\/2022\/9841070","type":"corrigendum","label":"Corrigendum","source":"publisher","updated":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T00:00:00Z","timestamp":1668556800000}},{"DOI":"10.1155\/2023\/9864707","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T00:00:00Z","timestamp":1689724800000}}],"container-title":["Computational and Mathematical Methods in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2022\/8660752.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2022\/8660752.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2022\/8660752.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T11:35:15Z","timestamp":1643456115000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cmmm\/2022\/8660752\/"}},"subtitle":[],"editor":[{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,1,29]]},"references-count":22,"alternative-id":["8660752","8660752"],"URL":"https:\/\/doi.org\/10.1155\/2022\/8660752","relation":{},"ISSN":["1748-6718","1748-670X"],"issn-type":[{"value":"1748-6718","type":"electronic"},{"value":"1748-670X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1,29]]}}}