{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T01:08:31Z","timestamp":1778893711853,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:00:00Z","timestamp":1661299200000},"content-version":"vor","delay-in-days":235,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011797","name":"Turku University Hospital","doi-asserted-by":"crossref","award":["11065"],"award-info":[{"award-number":["11065"]}],"id":[{"id":"10.13039\/501100011797","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contrast Media &amp; Molecular Imaging"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. In head and neck squamous cell carcinoma (HNSCC), the early diagnosis and efficient detection of recurrences and\/or residual tumor after treatment play a very important role in patient\u2019s prognosis. Positron emission tomography (PET) using 2\u2010deoxy\u20102\u2010<jats:sup>18<\/jats:sup>F\u2010fluoro\u2010D\u2010glucose (<jats:sup>18<\/jats:sup>F\u2010FDG) has become an established method for the diagnosis of suspected recurrence in head and neck carcinomas. In particular, integrated PET\/MRI imaging that provides optimal soft tissue contrast and less dental implant artifacts compared to PET\/CT is an intriguing technique for the follow\u2010up imaging of HNSCC patients. The aim of this study was to evaluate the benefit of PET\/MRI compared to PET\/CT in post\u2010treatment follow\u2010up imaging of HNSCC patients. <jats:italic>Methods<\/jats:italic>. This retrospective observational cohort study consists of 104 patients from our center with histologically confirmed HNSCC. All patients received chemoradiotherapy (CRT) and underwent <jats:sup>18<\/jats:sup>F\u2010FDG\u2010PET\/CT (<jats:italic>n<\/jats:italic>\u2009=\u200952) or <jats:sup>18<\/jats:sup>F\u2010FDG\u2010PET\/MRI (<jats:italic>n<\/jats:italic>\u2009=\u200952) scan 12 weeks after the end of treatment. Image analysis was performed by two independent readers according to a five\u2010point Likert scale analysis. <jats:italic>Results<\/jats:italic>. PET\/MRI was more sensitive (1.00 vs. 0.77) than PET\/CT in the detection of locoregional recurrence. PET\/MRI also had better negative (1.00 vs. 0.87) predictive values. AUCs for PET\/MRI and PET\/CT on patient\u2010based analysis were 0.997 (95% CI 0.989\u20131.000) and 0.890 (95% CI 0.806\u20130.974), respectively. The comparison of sensitivity, AUCs, and negative predictive values revealed a statistically significant difference, <jats:italic>p<\/jats:italic> &lt; 0.05. In PET\/CT, false\u2010negative and positive findings were observed in the more advanced disease stages, where PET\/MRI performed better. Also, false\u2010negative findings were located in the oropharyngeal, laryngeal, and nasopharyngeal regions, where PET\/MRI made no false\u2010negative interpretations. <jats:italic>Conclusion<\/jats:italic>. Based on these results, PET\/MRI might be considered the modality of choice in detecting locoregional recurrence in HNSCC patients, especially in the more advanced stages in the oral cavity, larynx, or nasopharynx.<\/jats:p>","DOI":"10.1155\/2022\/8676787","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T21:35:20Z","timestamp":1661376920000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Diagnostic Accuracy of <sup>18<\/sup>F\u2010FDG\u2010PET\/CT and <sup>18<\/sup>F\u2010FDG\u2010PET\/MRI in Detecting Locoregional Recurrence of HNSCC 12 Weeks after the End of Chemoradiotherapy: Single\u2010Center Experience with 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