{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:48:52Z","timestamp":1789778932675,"version":"4.0.1"},"reference-count":56,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:00:00Z","timestamp":1660089600000},"content-version":"vor","delay-in-days":221,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005891","name":"State Administration of Traditional Chinese Medicine of the People's Republic of China","doi-asserted-by":"publisher","award":["JDZX2015076"],"award-info":[{"award-number":["JDZX2015076"]}],"id":[{"id":"10.13039\/501100005891","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Osteoporotic fracture, a major complication which is known as the outcome postmenopausal osteoporosis, seriously threatens the health of postmenopausal women. At present, the traditional osteoporotic fracture prediction methods are characterized by inconvenient application and time\u2010consuming statistical results, while predictive serum biomarkers can make up for this shortcoming. Accurate and advanced risk prediction of osteoporotic fracture is meaningful to early prevention and intervention, effectively avoiding the risk of this disease and the secondary fracture in the surgical treatment. In this study, based on the BEYOND cohort, a 2\u2010year follow\u2010up study was conducted after subjects participated to survey if OF occurred. Independent sample <jats:italic>t<\/jats:italic> <jats:italic>-<\/jats:italic>test and Mann\u2013Whitney <jats:italic>U<\/jats:italic>\u2010test were used to analyze the differences of bone metabolism biomarkers between the OF and non\u2010OF group. Cox proportional hazard model was used to screen the potential biomarkers might be used to predict OF risk. ROC curves and AUCs were used to analyze the predictive accuracy, and the Delong\u2019s test was used to compare the differences between the AUCs. 15 postmenopausal women with low bone mass and OF were found, and other 60 subjects without OF were matched with 1\u2009:\u20094, age, and BMI classification as control group. The serum IL\u20106 (OR = 1.139, 95<jats:italic>%<\/jats:italic>CI = 1.058 \u2212 1.226) and leptin (OR = 0.921, 95<jats:italic>%<\/jats:italic>CI = 0.848 \u2212 1.000) were found as OF risk predictive biomarkers for postmenopausal women with low bone mass with high accuracy (IL \u2212 6 = 0.871) (leptin = 0.813) and accuracy enhanced when they were combined (AUC = 0.898). The results of Delong\u2019s test showed that the difference of AUC between leptin and IL\u20106&amp;Leptin was meaningful (<jats:italic>P<\/jats:italic> = 0.024) but meaningless between IL\u20106 and leptin (<jats:italic>P<\/jats:italic> = 0.436), IL\u20106 and IL\u20106&amp;Leptin (<jats:italic>P<\/jats:italic> = 0.606). To sum up, IL\u20106 and leptin are the predictive biomarkers of OF for postmenopausal women with low bone mass. The IL\u20106 can improve the prediction accuracy of leptin (<jats:italic>P<\/jats:italic> = 0.024), but not vice versa (<jats:italic>P<\/jats:italic> = 0.606). <jats:italic>Trial Information<\/jats:italic>. Registered on the Chinese Clinical Trial Registry already. (Registration Number: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.chictr.org.cn\/showproj.aspx?proj=22401\">ChiCTR-SOC-17013090<\/jats:ext-link>).<\/jats:p>","DOI":"10.1155\/2022\/8691830","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T22:20:09Z","timestamp":1660170009000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["IL\u20106 and Leptin Are Potential Biomarkers for Osteoporotic Fracture Risk Assessment and Prediction of Postmenopausal Women with Low Bone Mass: A Follow\u2010Up Study Using a Regional Sample Cohort"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8817-1805","authenticated-orcid":false,"given":"Xu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0044-8759","authenticated-orcid":false,"given":"Yili","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2985-079X","authenticated-orcid":false,"given":"Baoyu","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2167-3066","authenticated-orcid":false,"given":"Kai","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0185-0499","authenticated-orcid":false,"given":"Chuanrui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9395-2454","authenticated-orcid":false,"given":"Ning","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6150-4649","authenticated-orcid":false,"given":"Shengjie","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6723-9604","authenticated-orcid":false,"given":"Xu","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5359-4242","authenticated-orcid":false,"given":"Yanming","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4061-8668","authenticated-orcid":false,"given":"Liguo","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,10]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000001831"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32112-3"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4187"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3181f72b05"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08761-5"},{"key":"e_1_2_13_6_2","first-page":"l","article-title":"Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. 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