{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T15:57:20Z","timestamp":1757779040050,"version":"3.40.5"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T00:00:00Z","timestamp":1641254400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and Technology Project of Guangdong Province","award":["2013B022200003","2016YFC0906101","2016YFC0906100","2020B1212060028"],"award-info":[{"award-number":["2013B022200003","2016YFC0906101","2016YFC0906100","2020B1212060028"]}]},{"name":"National Key R&D Program of China","award":["2013B022200003","2016YFC0906101","2016YFC0906100","2020B1212060028"],"award-info":[{"award-number":["2013B022200003","2016YFC0906101","2016YFC0906100","2020B1212060028"]}]},{"name":"Key Laboratory of Nephrology, Guangdong Province, Guangzhou, China","award":["2013B022200003","2016YFC0906101","2016YFC0906100","2020B1212060028"],"award-info":[{"award-number":["2013B022200003","2016YFC0906101","2016YFC0906100","2020B1212060028"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2022,1,4]]},"abstract":"<jats:p>Background. The study is aimed at exploring the relationship of platelet-to-lymphocyte (PLR), all-cause, and cardiovascular disease (CVD) mortality in peritoneal dialysis (PD) patients based on gender. Methods. A total of 1438 PD patients from January 1,2007 to December 31, 2014 in PD center at The First Affiliated Hospital, Sun Yat-sen University, were included. Patients were followed up until December 31, 2019. The endpoint was all-cause mortality and CVD mortality. Cox proportional hazards regression models were used to evaluate the association of PLR with all-cause and CVD mortality to calculate hazard ratios (HR) and 95% confidence intervals (CI). Results. After a median of 48.9 (interquartile range [IQR]: 23.4-79.3) months of follow-up, 406 (28.2%) patients died based on all-cause death, among which 200 (49.3%) patients died from CVD. In the multivariate Cox regression model, we found that PLR was independently related to an increased risk of CVD mortality only in female PD patients, with HR of 1.003 (95% CI: 1.001-1.006). Interaction test showed that the correlation between PLR level for all-cause and CVD mortality varied with gender (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.042<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula> and <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.012<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>, respectively). Conclusion. Higher PLR was associated with a higher risk of CVD mortality in female PD patients.<\/jats:p>","DOI":"10.1155\/2022\/8760615","type":"journal-article","created":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T18:50:46Z","timestamp":1641322246000},"page":"1-9","source":"Crossref","is-referenced-by-count":7,"title":["Sexual Effect of Platelet-to-Lymphocyte Ratio in Predicting Cardiovascular Mortality of Peritoneal Dialysis Patients"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5124-1758","authenticated-orcid":true,"given":"Hui","family":"Sheng","sequence":"first","affiliation":[{"name":"Department of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 58th, Zhongshan Road II, Guangzhou 510080, China"},{"name":"Key Laboratory of Nephrology, National Health Commission of China and Guangdong Province, Guangzhou 510080, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0013-1484","authenticated-orcid":true,"given":"Yagui","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 58th, Zhongshan Road II, Guangzhou 510080, China"},{"name":"Key Laboratory of Nephrology, National Health Commission of China and Guangdong Province, Guangzhou 510080, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3146-5567","authenticated-orcid":true,"given":"Xi","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 58th, Zhongshan Road II, Guangzhou 510080, China"},{"name":"Key Laboratory of Nephrology, National Health Commission of China and Guangdong Province, Guangzhou 510080, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6579-0945","authenticated-orcid":true,"given":"Chunyan","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 58th, Zhongshan Road II, Guangzhou 510080, China"},{"name":"Key Laboratory of Nephrology, National Health Commission of China and Guangdong Province, Guangzhou 510080, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5778-6284","authenticated-orcid":true,"given":"Jianxiong","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 58th, Zhongshan Road II, Guangzhou 510080, China"},{"name":"Key Laboratory of Nephrology, National Health Commission of China and Guangdong Province, Guangzhou 510080, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0437-2015","authenticated-orcid":true,"given":"Xiao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 58th, Zhongshan Road II, Guangzhou 510080, China"},{"name":"Key Laboratory of Nephrology, National Health Commission of China and Guangdong Province, Guangzhou 510080, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0022-3784","authenticated-orcid":true,"given":"Fengxian","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 58th, Zhongshan Road II, Guangzhou 510080, China"},{"name":"Key Laboratory of Nephrology, National Health Commission of China and Guangdong Province, Guangzhou 510080, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1159\/000515541"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1159\/000368940"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2180373"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-018-1092-1"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-67054-x"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201902544RR"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2018.09.012"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9146042"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i34.6261"},{"issue":"48-56","key":"10","article-title":"Platelet-to-lymphocyte ratio in advanced cancer: review and meta-analysis","volume":"483","author":"B. 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