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Invasive breast cancer can be metastasized through axillary lymph nodes (LNs). This study was to evaluate the effectiveness of quantitative shear wave elastography (SWE) to predict axillary LN metastasis, which also provides prognostic implication of SWE as a histopathologic element of invasive breast cancer. Methods. 72 prospectively enrolled patients received B-mode ultrasound (BUS) and SWE, and the elasticity index (EI) of SWE at the stiffest part of lymph nodes (LNs) was measured. EI of SWE was closely associated with pathologic results and the histopathologic elements. The receiver operating characteristics (ROC) curve was drawn to evaluate the optimal cut-off value for the assessment of disease severity. Results. A significantly longer short-axis diameter and a larger maximal cortex were observed in malignant LNs than that in healthy LNs. The absence of the hilum was associated with metastatic LNs. The EI of SWE varied markedly between the benign and malignant LNs. The combination of Emax and BUS showed higher area under the curve (AUC) than BUS alone to predict metastatic LNs (0.7762 vs. 0.7230). EI of SWE in malignant lymph nodes those with extranodal extension are higher than those without extranodal extension. Conclusions. Quantitative SWE provides a viable alternative for the assessment of axillary LN and shows great potential to predict pathological prognostic elements of metastatic axillary LNs in invasive breast cancer. Joint use of SWE and BUS allows examination of the predictive outcome of BUS for axillary lymph node metastasis in invasive breast cancer.<\/jats:p>","DOI":"10.1155\/2022\/8769889","type":"journal-article","created":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T21:50:07Z","timestamp":1656453007000},"page":"1-6","source":"Crossref","is-referenced-by-count":7,"title":["Effectiveness of Quantitative Shear Wave Elastography for the Prediction of Axillary Lymph Node Metastasis"],"prefix":"10.1155","volume":"2022","author":[{"given":"Yingying","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Ultrasound, Harbin Medical University Cancer Hospital, Harbin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2605-2151","authenticated-orcid":true,"given":"Guofu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Harbin Medical University Cancer Hospital, Harbin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Harbin Medical University Cancer Hospital, Harbin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shasha","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Harbin Medical University Cancer Hospital, Harbin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Harbin Medical University Cancer Hospital, Harbin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8191-7624","authenticated-orcid":true,"given":"Wen","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Harbin Medical University Cancer Hospital, Harbin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19831101)52:9<1551::aid-cncr2820520902>3.0.co;2-3"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.5858\/2000-124-0966-pfibc"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.158.2.3510440"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-006-9106-9"},{"key":"5","first-page":"240","article-title":"Accuracy of ultrasound and clinical examination in the diagnosis of axillary lymph node metastases in breast cancer","volume":"17","author":"R. de Freitas","year":"1991","journal-title":"European Journal of Surgical Oncology: The Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23344"},{"key":"7","first-page":"9","article-title":"[Role of ultrasonography in the diagnosis of axillary lymph node metastases in breast cancer: a systematic review]","volume":"22","author":"S. 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