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Numerous plants used in traditional treatments, such as <jats:italic>Cotinus coggygria<\/jats:italic> Scop., have been effective in the treatment of diabetes mellitus (DM). Therefore, the study is aimed at assessing the phytochemical, antioxidant, and antidiabetic properties of <jats:italic>C. coggygria<\/jats:italic>. The hypoglycemic and hypolipidemic activity was evaluated in Swiss male Albino mice by administering an oral dose of 150\u2010250\u2009mg\/kg of <jats:italic>C. coggygria<\/jats:italic> extracts in alloxan\u2010induced diabetic mice for 15 days. The antioxidant activity and phytochemical composition of the extracts were assessed by using <jats:italic>\u03b1<\/jats:italic>, <jats:italic>\u03b1<\/jats:italic> diphenyl\u2010<jats:italic>\u03b2<\/jats:italic>\u2010picrylhydrazyl (DPPH) and hydrogen peroxide scavenging assays and through standard chemical procedures. The effects of extracts on blood glucose, body weight, lipid profile, and biochemical parameters like total cholesterol (TC), triglyceride (TG), low\u2010density lipids (LDL), high\u2010density lipids (HDL), plasma insulin, liver glycogen, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), urea, and creatinine were determined according to standard procedures. The activities of antioxidant enzymes such as superoxide\u2010dismutase (SOD), peroxidase (POD), and catalase (CAT) were also analyzed spectrophotometrically. The hypoglycemic and hypolipidemic effects with chloroform extracts of 250\u2009mg\/kg were found significant in the treatment of diabetes in alloxanised mice compared to the diabetic group. The haematological parameters such as TC, TG, HDL, LDL, creatinine, urea, AST, ALT, and ALP were significantly improved (<jats:italic>p<\/jats:italic> &lt; 0.01) by the chloroform extract of 250\u2009mg\/kg compared to the diabetic group. Treatment for 15 days showed significant elevation (<jats:italic>p<\/jats:italic> &lt; 0.01) of antioxidant enzymes. Fourier\u2010transform infrared spectroscopic (FTIR) and gas chromatography\u2013mass spectrometry (GC\u2010MS), column chromatography (CC), and nuclear magnetic resonance (NMR) analyses tentatively identified different phytoconstitutents and metabolites in <jats:italic>C. coggygria<\/jats:italic> leaves, which have been reported to possess antihyperglycemic properties. In conclusion, the chloroform extract of 250\u2009mg\/kg of <jats:italic>C. coggygria<\/jats:italic> possesses significant hypoglycemic and hypolipidemic potential which may prove the claimed use of the plant in amelioration of diabetes and associated complications in folkloric medicine. Additional studies are required for the purification, characterization, and structural elucidation of bioactive compounds.<\/jats:p>","DOI":"10.1155\/2022\/8802178","type":"journal-article","created":{"date-parts":[[2022,12,31]],"date-time":"2022-12-31T22:35:18Z","timestamp":1672526118000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Phytochemical Investigation and Therapeutical Potential of <i>Cotinus coggygria<\/i> Scop. in Alloxan\u2010Induced Diabetic Mice"],"prefix":"10.1155","volume":"2022","author":[{"given":"Shahid","family":"Rahman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4231-9581","authenticated-orcid":false,"given":"Gul","family":"Jan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzana Gul","family":"Jan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hafeez Ur","family":"Rahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,31]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2013.11.012"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2004.08.011"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1995-7645(11)60101-6"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.12.045"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2008.03.020"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1984-82502015000100001"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2010.02.001"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.3767\/000651906X622427"},{"key":"e_1_2_10_9_2","first-page":"179","article-title":"Halk arasinda diyabete kar\u015fi kullanilan bitkiler T\u00fcrkiye-II","volume":"2","author":"Ar\u0131tuluk Z. 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