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In the invention of antimalarial substances, claimed medical plants are precious resources. So, the current study was designed to assess the antiplasmodial effects of <jats:italic>Maesa lanceolata<\/jats:italic> in mice. In this study, preliminary phytoconstituent and <jats:italic>in vivo<\/jats:italic> acute oral toxicity tests were done. Early infection, established infection, and residual infection tests were employed to determine the antimalarial effects of the test drugs. Three doses (200, 400, and 600\u2009mg\/kg) of the extracts were provided orally to the test mice. Analysis of variance (one\u2010way) followed by post hoc Tukey\u2019s test was used to analyze the difference between and within groups. Terpenoids, tannins, saponins, flavonoids, and alkaloids were detected in the phytochemical constituent analysis. Both 80% methanolic crude extract and solvent fractions had no toxic result at the 2000\u2009mg\/kg dose. All test drug doses suppressed parasite levels in a significant manner at all tests. The activity of chloroform fraction (maximum percentage suppression, 81.28%) overwhelms the crude extract activity. The curative effects of 80% methanolic crude extract, with a maximum of 80.22% parasitemia suppression, were greater than its suppressive and prophylactic effects. The 400\u2009mg\/kg dose of chloroform fraction resulted in a maximum survival period (18 days) than other doses of tested materials. The results of this investigation provide support for the activity of <jats:italic>M. lanceolata<\/jats:italic> leaf extract against malaria.<\/jats:p>","DOI":"10.1155\/2022\/8901555","type":"journal-article","created":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T17:50:08Z","timestamp":1668275408000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Suppressive, Curative, and Prophylactic Effects of <i>Maesa lanceolata<\/i> Forssk. against Rodent Malaria Parasite <i>Plasmodium berghei<\/i>"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3284-5951","authenticated-orcid":false,"given":"Eyob","family":"Tekalign","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2582-5872","authenticated-orcid":false,"given":"Getnet","family":"Tadege","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8296-3104","authenticated-orcid":false,"given":"Nebeyi","family":"Fisseha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9919-8376","authenticated-orcid":false,"given":"Dejen","family":"Nureye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,12]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.21468"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-022-12571-9"},{"key":"e_1_2_9_3_2","volume-title":"World Health Organization","author":"WHO","year":"2021"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2020.02.016"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fitd.2021.771030"},{"key":"e_1_2_9_6_2","volume-title":"Malaria","author":"USAID Ethiopia","year":"2022"},{"key":"e_1_2_9_7_2","unstructured":"MijnRadboud New malaria mosquito is emerging in African cities Radboudumc 2021 https:\/\/www.radboudumc.nl\/en\/news\/2021\/new-malaria-mosquito-is-emerging-in-african-cities."},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-021-07376-5"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.12944"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(22)00039-8"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(21)00748-9"},{"key":"e_1_2_9_12_2","volume-title":"Technical Document of the Use of Non-pharmaceutical Forms of Artemisia","author":"WHO","year":"2019"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(03)00428-X"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(03)01172-5"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/np990028s"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/np980235c"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/np50060a028"},{"key":"e_1_2_9_18_2","unstructured":"TaddeseS. 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