{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:51:40Z","timestamp":1747191100383,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T00:00:00Z","timestamp":1641945600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2022,1,12]]},"abstract":"<jats:p>Introduction. The risk of extended spectrum \u03b2-lactamase (ESBL) bacterial acquisition in patients with \u03b2-lactam allergy has been poorly investigated. In a previous study conducted over a 6-year long period (2007-2012), we found that patients with declared \u03b2-lactam allergy had a higher risk of ESBL bacterial carriage at admission in intensive care unit (ICU), but they had not a higher risk of ESBL bacterial acquisition. We present the final results of the study which was eventually conducted over a 12-year long period (2007-2018). Materials and Methods. The study included all patients admitted in ICU and receiving antibiotic treatment from January 2007 to December 2018. ESBL bacterial acquisition was the main clinical outcome. Mortality in ICU, multidrug resistant bacterial carriage at admission and discharge were the secondary outcomes. Results. Overall, 3332 patients were included, 132\/3332 (3.9%) were labelled \u03b2-lactam allergic, while 3200\/3332 (96.1%) did not presented \u03b2-lactam allergy. No significant difference in rates of ESBL acquisition was detected (4\/132, 3% vs. 78\/3200, 2.4%;<jats:inline-formula><a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><a:mi>p<\/a:mi><a:mo>=<\/a:mo><a:mn>0.17<\/a:mn><\/a:math><\/jats:inline-formula>). Patients with \u03b2-lactam allergy had higher rates of ESBL bacterial carriage at admission (19\/132, 14.4% vs. 248\/3200, 7.8%,<jats:inline-formula><c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><c:mi>p<\/c:mi><c:mo>=<\/c:mo><c:mn>0.01<\/c:mn><\/c:math><\/jats:inline-formula>) and at discharge (22\/132, 16.7% vs. 351\/3200, 11%,<jats:inline-formula><e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><e:mi>p<\/e:mi><e:mo>=<\/e:mo><e:mn>0.04<\/e:mn><\/e:math><\/jats:inline-formula>) than nonallergic patients. No differences in mortality, duration of hospitalization, and carriage of methicillin resistant Staphylococcus aureus were reported. Female gender was the only factor associated with \u03b2-lactam allergy at the multivariate analysis. Conclusions. This study confirms that patients with declared \u03b2-lactam allergy had not a higher risk of ESBL bacterial acquisition during hospitalization in ICU. However, they had a higher ESBL bacterial carriage at admission.<\/jats:p>","DOI":"10.1155\/2022\/8906316","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T16:35:09Z","timestamp":1642005309000},"page":"1-6","source":"Crossref","is-referenced-by-count":3,"title":["Risk of Multidrug Resistant Bacteria Acquisition in Patients with Declared \u03b2-Lactam Allergy during Hospitalization in Intensive Care Unit: A Retrospective Cohort Study (2007-2018)"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0199-3449","authenticated-orcid":true,"given":"Alessio","family":"Strazzulla","sequence":"first","affiliation":[{"name":"Internal Medicine Unit, Groupe Hospitalier Sud Ile de France, Melun, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Concetta","family":"Postorino","sequence":"additional","affiliation":[{"name":"Public Health Unit, Groupe Hospitalier Sud Ile de France, Melun, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nabil","family":"Belfeki","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit, Groupe Hospitalier Sud Ile de France, Melun, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Iordache","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit, Centre Hospitalier Sud Seine et Marne, Fontainebleau, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid","family":"de Pontfarcy","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Groupe Hospitalier Sud Ile de France, Melun, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurelia","family":"Pitsch","sequence":"additional","affiliation":[{"name":"Biology Laboratory, Groupe Hospitalier Sud Ile de France, Melun, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Leroy","sequence":"additional","affiliation":[{"name":"Public Health Unit, Groupe Hospitalier Sud Ile de France, Melun, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastien","family":"Jochmans","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Groupe Hospitalier Sud Ile de France, Melun, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehran","family":"Monchi","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Groupe Hospitalier Sud Ile de France, Melun, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvain","family":"Diamantis","sequence":"additional","affiliation":[{"name":"Public Health Unit, Groupe Hospitalier Sud Ile de France, Melun, France"},{"name":"Infectious Diseases Unit, Groupe Hospitalier Sud Ile de France, Melun, France"},{"name":"Research Unit \u201cDYNAMIC\u201d, Universit\u00e9 Paris-Est Cr\u00e9teil, Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2014.35.3791"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0150514"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics7030071"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2018.155"},{"volume-title":"Antimicrobial Resistance: Global Report on Surveillance","year":"2014","author":"World Health Organization","key":"5"},{"issue":"4","key":"6","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S1441-2772(23)00552-5","article-title":"The burden of antibiotic allergies in adults in an Australian intensive care unit: the BASIS study","volume":"21","author":"R. L. Moran","year":"2019","journal-title":"Critical Care and Resuscitation"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2019.09.021"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k2400"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00187-16"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2020.105979"},{"key":"11","article-title":"Journal officiel de la R\u00e9publique Fran\u00e7aise: LOI n\u00b0 2012-300 du 5 mars 2012 relative aux recherches impliquant la personne humaine (1)"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.therap.2016.12.006"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.1150"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr458"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks464"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12803"},{"author":"Sant\u00e9 publique France, Direction de la communication \/ Unit\u00e9 de valorisation scientifique","key":"18","article-title":"Consommation d\u2019antibiotiques et resistance aux antibiotique en France : soyons concern\u00e9s , soyons responsables! Novembre 2017"},{"author":"P. Cavali\u00e9","key":"19","article-title":"Consommation d\u2019antibiotiques en secteur de ville en France de 2009 a 2019"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2020.09.006"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.7018"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.2147\/JAA.S242061"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2018.12.001"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-021-04184-8"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2093468"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-019-03656-2"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.2174\/138920111798808301"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-019-0572-9"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000026494"}],"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2022\/8906316.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2022\/8906316.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2022\/8906316.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T19:14:20Z","timestamp":1700075660000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jir\/2022\/8906316\/"}},"subtitle":[],"editor":[{"given":"Baohui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,1,12]]},"references-count":29,"alternative-id":["8906316","8906316"],"URL":"https:\/\/doi.org\/10.1155\/2022\/8906316","relation":{},"ISSN":["2314-7156","2314-8861"],"issn-type":[{"type":"electronic","value":"2314-7156"},{"type":"print","value":"2314-8861"}],"subject":[],"published":{"date-parts":[[2022,1,12]]}}}