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The levels of cytokines were analyzed in the groups with and without virus-related FHI. Among the patients, 50% had rubella virus, 5.26% had cytomegalovirus, and 2.63% had herpes simplex virus infections. The expression of interleukin-6 (IL-6) and IL-8 was significantly higher, and that of basic fibroblast growth factor (bFGF) was significantly lower in the virus-positive group than in the virus-negative group (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.015<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.001<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>, and <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>0.001<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>, respectively). Although there was no significant difference in the mean expression of vascular cell adhesion protein 1 (VCAM-1), IL-10, and vascular endothelial growth factor (VEGF), that of VCAM-1 and IL-10 was higher (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>M<\/g:mi>\n                        <g:mo>=<\/g:mo>\n                        <g:mn>1338<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula> and <jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>M<\/i:mi>\n                        <i:mo>=<\/i:mo>\n                        <i:mn>1390<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>, respectively; <jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>M<\/k:mi>\n                        <k:mo>=<\/k:mo>\n                        <k:mn>6.225<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula> and 10.600, respectively) and that of VEGF was lower (<jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mi>M<\/m:mi>\n                        <m:mo>=<\/m:mo>\n                        <m:mn>134.5<\/m:mn>\n                     <\/m:math>\n                  <\/jats:inline-formula> and <jats:inline-formula>\n                     <o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                        <o:mi>M<\/o:mi>\n                        <o:mo>=<\/o:mo>\n                        <o:mn>38.70<\/o:mn>\n                     <\/o:math>\n                  <\/jats:inline-formula>, respectively) in the virus-positive group than in the virus-negative group. Similar findings were observed for the expressions of IL-6, IL-8, and bFGF in the rubella-positive and rubella-negative groups. Viral presence was highly related to FHI, especially that of the rubella virus. High levels of inflammatory cytokines and low levels of neovascularization-related factors are involved in rubella-related FHI. These study findings could be helpful in the diagnosis and treatment of FHI.<\/jats:p>","DOI":"10.1155\/2022\/8906752","type":"journal-article","created":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T19:50:07Z","timestamp":1644263407000},"page":"1-6","source":"Crossref","is-referenced-by-count":1,"title":["Cytokine Changes in the Aqueous Humor in Rubella-Related Fuchs Heterochromic Iridocyclitis"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1177-2183","authenticated-orcid":true,"given":"Yi","family":"Mao","sequence":"first","affiliation":[{"name":"Eye Institute and Affiliated Xiamen Eye Center of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361002, China"},{"name":"Fujian Key Laboratory of Ocular Surface and Corneal Diseases, Xiamen University, Xiamen 361002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9729-6818","authenticated-orcid":true,"given":"Sijie","family":"Lin","sequence":"additional","affiliation":[{"name":"Eye Institute and Affiliated Xiamen Eye Center of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361002, China"},{"name":"Fujian Key Laboratory of Ocular Surface and Corneal Diseases, Xiamen University, Xiamen 361002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0556-5938","authenticated-orcid":true,"given":"Chengfang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Eye Institute and Affiliated Xiamen Eye Center of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361002, China"},{"name":"Fujian Key Laboratory of Ocular Surface and Corneal Diseases, Xiamen University, Xiamen 361002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1237-7326","authenticated-orcid":true,"given":"Xiaodong","family":"Liu","sequence":"additional","affiliation":[{"name":"Eye Institute and Affiliated Xiamen Eye Center of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361002, China"},{"name":"Fujian Key Laboratory of Ocular Surface and Corneal Diseases, Xiamen University, Xiamen 361002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9683-1620","authenticated-orcid":true,"given":"Huping","family":"Wu","sequence":"additional","affiliation":[{"name":"Eye Institute and Affiliated Xiamen Eye Center of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361002, China"},{"name":"Fujian Key Laboratory of Ocular Surface and Corneal Diseases, Xiamen University, Xiamen 361002, 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