{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T21:53:39Z","timestamp":1782856419066,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T00:00:00Z","timestamp":1669593600000},"content-version":"vor","delay-in-days":331,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100011789","name":"Department of Science and Technology of Jilin Province","doi-asserted-by":"publisher","award":["20210204119YY"],"award-info":[{"award-number":["20210204119YY"]}],"id":[{"id":"10.13039\/501100011789","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Hypertension"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    <jats:italic>Objective<\/jats:italic>\n                    . Cardiopulmonary exercise testing (CPET) has been used to explore the blood pressure response and potential cardiovascular system structure and dysfunction in male patients with essential hypertension during exercise, to provide a scientific basis for safe and effective exercise rehabilitation and improvement of prognosis.\n                    <jats:italic>Methods<\/jats:italic>\n                    . A total of 100 male patients with essential hypertension (aged 18\u201360) who were admitted to the outpatient department of the Center for Diagnosis and Treatment of Cardiovascular Diseases of Jilin University from September 2018 to January 2021 were enrolled in this study. The patients had normal cardiac structure in resting state without clinical manifestations of heart failure or systematic regularization of treatment at the time of admission. Symptom\u2010restricted CPET was performed and blood pressure was measured during and after exercise. According to Framingham criteria, male systolic blood pressure (SBP) \u2265210\u2009mmHg during exercise was defined as exercise hypertension (EH), and the subjects were divided into EH group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200947) and non\u2010EH group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200953). Based on whether the oxygen pulse (VO\n                    <jats:sub>2<\/jats:sub>\n                    \/HR) plateau appeared immediately after anaerobic threshold (AT), the EH group was further divided into the VO\n                    <jats:sub>2<\/jats:sub>\n                    \/HR plateau immediately after AT (EH\u2010ATP) group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200919) and EH\u2010non\u2010ATP group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200928). The basic clinical data and related parameters, key CPET indicators, were compared between groups.\n                    <jats:italic>Result<\/jats:italic>\n                    . Body mass index (BMI) visceral fat, resting SBP, and SBP variability in EH group were significantly higher than those in non\u2010EH group. Moreover, VO\n                    <jats:sub>2<\/jats:sub>\n                    \/HR at AT and the ratio of VO\n                    <jats:sub>2<\/jats:sub>\n                    \/HR plateau appearing immediately after AT in EH group were significantly higher than those in the non\u2010EH group. The resting SBP, 15\u2010minute SBP variability, and the presence of VO\n                    <jats:sub>2<\/jats:sub>\n                    \/HR plateau were independent risk factors for EH. In addition, work rate (WR) at AT but also WR, oxygen consumption per minute (VO\n                    <jats:sub>2<\/jats:sub>\n                    ), VO\n                    <jats:sub>2<\/jats:sub>\n                    \/kg, and VO\n                    <jats:sub>2<\/jats:sub>\n                    \/HR at peak were significantly lower in the EH\u2010ATP group compared to the EH\u2010non\u2010ATP group. Peak diastolic blood pressure (DBP) increment and decreased \u25b3VO\n                    <jats:sub>2<\/jats:sub>\n                    \/\u25b3WR for AT to peak were independent risk factors for VO\n                    <jats:sub>2<\/jats:sub>\n                    \/HR plateau appearing immediately after AT in EH patients.\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . EH patients have impaired autonomic nervous function and are prone to exercise\u2010induced cardiac dysfunction. EH patients with exercise\u2010induced cardiac dysfunction have reduced peak cardiac output and exercise tolerance and impaired vascular diastolic function. CPET examination should be performed on EH patients and EH patients with exercise\u2010induced cardiac dysfunction to develop precise drug therapy and effective individual exercise prescription, to avoid arteriosclerosis and exercise\u2010induced cardiac damage. The retrospective study protocol was approved by medical ethics committee of the First Hospital of Jilin University (AF\u2010IRB\u2010032\u201006 No. 2021\u2010015). The study was registered with the Chinese Clinical Trials Register, registration number:\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/ChiCTR2100053140\">ChiCTR2100053140<\/jats:ext-link>\n                    .\n                  <\/jats:p>","DOI":"10.1155\/2022\/8910453","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T14:20:06Z","timestamp":1669645206000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Exercise\u2010Induced Excessive Blood Pressure Elevation Is Associated with Cardiac Dysfunction in Male Patients with Essential 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