{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T23:46:44Z","timestamp":1784072804321,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T00:00:00Z","timestamp":1654819200000},"content-version":"vor","delay-in-days":160,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Clinical Practice"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. The present study aims to investigate the relationship between vitamin D deficiency and renin\u2010angiotensin\u2010aldosterone levels in patients with essential hypertension. <jats:italic>Methods<\/jats:italic>. The present study observed two groups of patients from Urumqi, Xinjiang, China, from April 2017 to March 2018. There were two subject groups: the hypertension group (80 patients with essential hypertension selected by random cluster sampling) and the control group (76 healthy adults). The 25\u2010hydroxyvitamin D (25(OH)D or vitamin D) levels were measured through electrolytes; fasting blood glucose, blood lipids, and other biochemical indicators were detected using immune chemiluminescence; and plasma renin activity and angiotensin II concentrations were detected with radio\u2010immunity. <jats:italic>Results<\/jats:italic>. Comparison between the hypertension group and control group showed statistically significant differences in the systolic pressure and levels of 25(OH)D, renin, and triglycerides (<jats:italic>P<\/jats:italic> &lt; 0.05). The correlation analysis showed that 25(OH)D was negatively correlated with renin (<jats:italic>r<\/jats:italic>\u2009=\u2009\u20130.185; <jats:italic>P<\/jats:italic> = 0.021) and positively correlated with systolic pressure (<jats:italic>r<\/jats:italic>\u2009=\u2009\u20130.105; <jats:italic>P<\/jats:italic> = 0.035). There were no statistically significant differences in diastolic pressure, fasting blood glucose, total cholesterol, low\u2010density lipoprotein cholesterol, high\u2010density lipoprotein cholesterol, and triglycerides between the two groups. <jats:italic>Conclusions<\/jats:italic>. The results of the present study show that vitamin D deficiency is common in Urumqi, Xinjiang, China and vitamin D levels are negatively correlated with renin levels. Vitamin D plays an important role in regulating blood pressure by affecting renin levels through the renin\u2010angiotensin\u2010aldosterone system.<\/jats:p>","DOI":"10.1155\/2022\/8975396","type":"journal-article","created":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T12:35:35Z","timestamp":1654864535000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Association between Vitamin D Deficiency and Levels of Renin and Angiotensin in Essential 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