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Phenolic compounds, such as gastrodin, <jats:italic>para<\/jats:italic>\u2010hydroxybenzyl alcohol (HBA), <jats:italic>p<\/jats:italic>\u2010hydroxybenzaldehyde, and vanillin are the main bioactive components isolated from <jats:italic>Gastrodia elata<\/jats:italic>. These compounds not only are structurally related but also share similar pharmacological activities, such as antioxidative and anti\u2010inflammatory activities, and effects on the treatment of aging\u2010related diseases. Here, we investigated the effect of <jats:italic>para<\/jats:italic>\u2010hydroxybenzyl alcohol (HBA) on neurodegenerative diseases and aging in models of <jats:italic>Caenorhabditis elegans<\/jats:italic> (<jats:italic>C. elegans<\/jats:italic>). Our results showed that HBA effectively delayed the progression of neurodegenerative diseases, such as Alzheimer\u2019s disease, Parkinson\u2019s disease, and Huntington\u2019s disease in models of <jats:italic>C. elegans<\/jats:italic>. In addition, HBA could increase the average lifespan of N2 worms by more than 25% and significantly improve the age\u2010related physiological functions of worms. Moreover, HBA improved the survival rate of worms under stresses of oxidation, heat, and pathogenic bacteria. Further mechanistic investigation revealed that HBA could activate FOXO\/DAF\u201016 and SKN\u20101 to regulate antioxidative and xenobiotic metabolism pathway. HBA could also activate HSF\u20101 to regulate proteostasis maintenance pathway, mitochondrial unfolded stress response, endoplasmic stress response and autophagy pathways. The above results suggest that HBA activated multiple cellular protective pathways to increase stress resistance and protect against aging and aging\u2010related diseases. Overall, our study indicates that HBA is a potential candidate for future development of antiaging pharmaceutical application.<\/jats:p>","DOI":"10.1155\/2022\/8986287","type":"journal-article","created":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:35:16Z","timestamp":1648773316000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["<i>Para<\/i>\u2010Hydroxybenzyl Alcohol Delays the Progression of Neurodegenerative Diseases in Models of <i>Caenorhabditis elegans<\/i> through Activating Multiple Cellular Protective 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