{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:58:55Z","timestamp":1792612735941,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T00:00:00Z","timestamp":1654473600000},"content-version":"vor","delay-in-days":156,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100011696","name":"Shahed University","doi-asserted-by":"publisher","award":["1355"],"award-info":[{"award-number":["1355"]}],"id":[{"id":"10.13039\/501100011696","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Dentistry"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    <jats:italic>Aim<\/jats:italic>\n                    . Interleukin\u20101 beta (IL\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    ) is one of the major biomarkers involved in the pathogenesis of chronic periodontitis. The aim of this study was to evaluate the changes in salivary IL\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    concentration in patients with chronic periodontitis following daily consumption of green tea.\n                    <jats:italic>Methods and Materials<\/jats:italic>\n                    . Thirty patients with an average age of 45.8 years suffering from chronic periodontitis were randomly assigned into 2 groups (i.e., experimental and control groups). Besides receiving phase 1 periodontal treatment (scaling and root planning (SRP)), the experimental group drank green tea for a period of 6 weeks. To measure the concentration of salivary IL\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    , saliva samples were taken from both groups at 2 time points, i.e., prior to SRP (time point 1 (T0)) and after 6 weeks (time point 2 (T1)). The nonparametric Wilcoxon test was used to examine and compare the changes in the concentration of salivary IL\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    in each group relevant to the 2 time points (T0 and T1). Data were submitted to statistical analysis.\n                    <jats:italic>Results<\/jats:italic>\n                    . At the end of the study period, a significant reduction (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.0001) in the concentration of salivary IL\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    was observed in the experimental group (\n                    <jats:italic>A<\/jats:italic>\n                    ). As for the control group (\n                    <jats:italic>B<\/jats:italic>\n                    ), however, there was no significant change (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.307) in the concentration of salivary IL\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    after 6 weeks following phase 1 periodontal treatment.\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . Green tea supplementation, in addition to SRP, may reduce salivary IL\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    levels in patients with chronic periodontitis for a period of 6 weeks.\n                  <\/jats:p>","DOI":"10.1155\/2022\/8992313","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T15:20:07Z","timestamp":1654528807000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effect of Green Tea on the Level of Salivary Interleukin\u20101 Beta in Patients with Chronic Periodontitis: A Randomized Clinical Trial"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4093-9827","authenticated-orcid":false,"given":"Gita","family":"Rezvani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4348-0759","authenticated-orcid":false,"given":"Ferial","family":"Taleghani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4656-8497","authenticated-orcid":false,"given":"Maryam","family":"Valizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,6]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12002"},{"key":"e_1_2_10_2_2","first-page":"1","article-title":"The role of interleukin-1 beta in the pathophysiology of periodontal disease: a literature review","volume":"9","author":"Fr\u00f3es A.","year":"2020","journal-title":"Research, Society and Development"},{"key":"e_1_2_10_3_2","first-page":"12","article-title":"Green tea-a short review","volume":"30","author":"Shrivastava R. 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