{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:19:51Z","timestamp":1767169191166,"version":"build-2238731810"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Joint project of Chongqing Health Commission and Science and Technology Bureau","award":["2020FYYX126"],"award-info":[{"award-number":["2020FYYX126"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,10,17]]},"abstract":"<jats:p>\n                    Aims. This study aimsto investigate the relationship between peripheral blood neutrophil\/lymphocyte ratio (NLR), platelet\/lymphocyte ratio (PLR), systemic immune-inflammatory index (SII), and procalcitonin (PCT), C-reactive protein (CRP), and pediatric critical illness score (PCIS) in infants with community-acquired pneumonia (CAP). Methods. 100 infants with bacterial CAP admitted to our hospital between January 2021 and December 2021 were selected as the infected group, and another 100 healthy infants who underwent health check-ups at the same time were selected as the control group, and the NLR, PLR, and SII of peripheral blood of infants in both groups and the serum PCT, CRP, and PCIS scores of infants in the infected group were tested. The correlation between NLR, PLR, SII, and PCT, CRP, and PCIS was analyzed by Spearman\u2019s analysis. Results. The peripheral blood levels of NLR, PLR, and SII were higher in the infected group than in the control infants (\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    ). The ROC results showed that the AUCs of peripheral blood NLR, PLR, and SII for the diagnosis of infants with CAP were 0.934, 0.737, and 0.882, respectively. The ROC results showed that the AUCs of peripheral blood NLR, PLR, and SII for assessing the extent of disease in infants with CAP were 0.815, 0.710, and 0.813, respectively, with best cut-off values of 2.05, 98.57, and 823.41; the joint predicted AUC was 0.862. Conclusions. NLR, PLR, and SII were significantly elevated in the peripheral blood of infants with CAP, positively correlated with PCT and CRP, and negatively correlated with PSIC scores, and NLR and SII also have some guiding value in early diagnosis and assessment of the extent of the disease in infants and toddlers with CAP.\n                  <\/jats:p>","DOI":"10.1155\/2022\/9024969","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T16:50:06Z","timestamp":1666025406000},"page":"1-6","source":"Crossref","is-referenced-by-count":5,"title":["Research on the Correlation of Peripheral Blood Inflammatory Markers with PCT, CRP, and PCIS in Infants with Community-Acquired Pneumonia"],"prefix":"10.1155","volume":"2022","author":[{"given":"Linwei","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Jiangjin Hospital Affiliated to Chongqing University, No. 725, Jiangzhou Avenue, Dingshan Street, Jiangjin District, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyun","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Jiangjin Hospital Affiliated to Chongqing University, No. 725, Jiangzhou Avenue, Dingshan Street, Jiangjin District, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Jiangjin Hospital Affiliated to Chongqing University, No. 725, Jiangzhou Avenue, Dingshan Street, Jiangjin District, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengjie","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Jiangjin Hospital Affiliated to Chongqing University, No. 725, Jiangzhou Avenue, Dingshan Street, Jiangjin District, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5820-1655","authenticated-orcid":true,"given":"Xiaoyong","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Jiangjin Hospital Affiliated to Chongqing University, No. 725, Jiangzhou Avenue, Dingshan Street, Jiangjin District, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/s2213-2600(13)70075-4"},{"issue":"14","key":"2","first-page":"2104","article-title":"Diagnostic value of chemiluminescence combined with quantitative PCR for cytomegalovirus infection combined with pneumonia in infants and children","volume":"40","author":"J. T. Lai","year":"2019","journal-title":"Guangdong Medical Journal"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.compeleceng.2022.108029"},{"issue":"12","key":"4","first-page":"941","article-title":"Analysis of the relationship between bacterial infections of the lower respiratory tract and persistent wheezing in infants and infants and the efficacy of antibiotics","volume":"31","author":"F. X. Ding","year":"2016","journal-title":"Chinese Journal of Practical Pediatrics"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000012177"},{"key":"6","first-page":"6","article-title":"Guidelines for the management of community-acquired pneumonia in children","volume":"12","author":"National Health Commission of the People\u2019s Republic of China State Administration of Traditional Chinese Medicine","year":"2019","journal-title":"Chinese Journal of Clinical Infectious Diseases"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.compeleceng.2022.108085"},{"issue":"2","key":"8","first-page":"189","article-title":"Pathogenetic characteristics and drug resistance analysis of 748 cases of severe community-acquired pneumonia in children in Chongqing","volume":"18","author":"Y. W. Long","year":"2021","journal-title":"Laboratory Medicine and Clinic"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.compeleceng.2021.107024"},{"issue":"10","key":"10","first-page":"1751","article-title":"Changes and significance of ultrasensitive C-reactive protein calcitoninogen and cellular immune indexes in peripheral blood of children with pneumonia","volume":"23","author":"J. Zhu","year":"2019","journal-title":"Chinese Journal of Laboratory Diagnosis"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2019.10.023"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.23935"},{"issue":"4","key":"13","first-page":"641","article-title":"Clinical application value of neutrophil\/lymphocyte ratio in evaluating the severity of mycoplasma pneumonia in children","volume":"37","author":"R. F. Chen","year":"2022","journal-title":"Maternal and Child Health Care of China"},{"issue":"5","key":"14","first-page":"42","article-title":"Correlation analysis of CD64 index, NLR level and serum antibody potency in peripheral blood of children with Mycoplasma pneumoniae pneumonia","volume":"34","author":"M. Jiang","year":"2022","journal-title":"Medical and Pharmaceutical Journal of Chinese People\u2019s Liberation Army"},{"issue":"4","key":"15","first-page":"487","article-title":"Significance of NLR and PLR in the diagnosis and prognostic assessment of neonatal infectious pneumonia","volume":"47","author":"G. L. Lu","year":"2022","journal-title":"Journal of Guangxi Medical University"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.4149\/bll_2021_069"},{"issue":"8","key":"17","first-page":"575","article-title":"Value of combined blood calcitoninogen, brain natriuretic peptide, D-dimer and PCIS score in assessing the prognosis of severe pneumonia in children","volume":"35","author":"W. Guo","year":"2017","journal-title":"Journal of Clinical Pediatrics"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1691801"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.17843"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1097\/inf.0000000000002098"}],"updated-by":[{"DOI":"10.1155\/2023\/9756215","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:00:00Z","timestamp":1691539200000},"record-id":"51285"},{"DOI":"10.1155\/2023\/9756215","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:00:00Z","timestamp":1691539200000}}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/9024969.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/9024969.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/9024969.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T16:50:20Z","timestamp":1666025420000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ecam\/2022\/9024969\/"}},"subtitle":[],"editor":[{"given":"Muhammad Farrukh","family":"Nisar","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,10,17]]},"references-count":20,"alternative-id":["9024969","9024969"],"URL":"https:\/\/doi.org\/10.1155\/2022\/9024969","relation":{},"ISSN":["1741-4288","1741-427X"],"issn-type":[{"value":"1741-4288","type":"electronic"},{"value":"1741-427X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10,17]]}}}