{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:23:11Z","timestamp":1767165791986,"version":"build-2238731810"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T00:00:00Z","timestamp":1657843200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2022,7,15]]},"abstract":"<jats:p>\n                    Objective. To investigate the effect of annular external fixator-assisted bone transport in the treatment of traumatic massive bone defect of tibia on clinical healing, pain stress, and joint function. Methods. From January 2018 to November 2021, 146 patients with traumatic massive bone defect of tibia were selected as the research objects, and they were divided into observation group (annular external fixator-assisted bone transport, 71 cases) and control group (unilateral external fixator bone lengthening, 75 cases) according to different surgical methods. The therapeutic efficacy, fracture healing-related indexes, and postoperative range of motion of the knee joint were compared between the two groups. Callus healing was evaluated by Fernandez-Esteve callus score, and joint function was evaluated by Paley score, American Knee society score (AKSS), and Baird-Jackson ankle score. The changes of pain mediator (serum substance P (SP), neuropeptide Y (NPY), prostaglandin E2 (PGE2), and tumor necrosis factor-\u03b1 (TNF-\u03b1)) and stress indexes (adrenocorticotropic hormone (ACTH), cortisol (COR), and nor Epinephrine (NE)) were observed before and after treatment in two groups. The incidence of postoperative complications was analyzed. Results. There were no significant differences in total effective rate and bone lengthening between the two groups (\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&gt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    ). The bone healing time and callus formation time in the observation group were shorter than those in the control group, and the Fernandez-Esteve callus score was higher than that in the control group (\n                    <jats:inline-formula>\n                      <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                      <\/c:math>\n                    <\/jats:inline-formula>\n                    ). The levels of SP, NPY, PGE2, TNF-\u03b1, ACTH, COR, and NE in the observation group were lower than those in the control group (\n                    <jats:inline-formula>\n                      <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.05<\/e:mn>\n                      <\/e:math>\n                    <\/jats:inline-formula>\n                    ). AKSS and Baird-Jackson scores in the observation group after operation were higher than those in the control group (\n                    <jats:inline-formula>\n                      <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>&lt;<\/g:mo>\n                        <g:mn>0.05<\/g:mn>\n                      <\/g:math>\n                    <\/jats:inline-formula>\n                    ). There was no significant difference in the incidence of postoperative complications between the two groups (\n                    <jats:inline-formula>\n                      <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>P<\/i:mi>\n                        <i:mo>&gt;<\/i:mo>\n                        <i:mn>0.05<\/i:mn>\n                      <\/i:math>\n                    <\/jats:inline-formula>\n                    ). Conclusion. Annular external fixator-assisted bone transport can promote postoperative fracture healing, reduce pain stress level, and improve joint function of patients with traumatic massive bone defect of tibia.\n                  <\/jats:p>","DOI":"10.1155\/2022\/9052770","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T20:20:09Z","timestamp":1657916409000},"page":"1-8","source":"Crossref","is-referenced-by-count":7,"title":["Effect of Annular External Fixator-Assisted Bone Transport on Clinical Healing, Pain Stress and Joint Function of Traumatic Massive Bone Defect of Tibia"],"prefix":"10.1155","volume":"2022","author":[{"given":"Xiaoliang","family":"Song","sequence":"first","affiliation":[{"name":"Hand Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China"},{"name":"Department of Orthopaedics, Changzhi Second People\u2019s Hospital, Changzhi, Shanxi 046000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7220-6639","authenticated-orcid":true,"given":"Xinzhong","family":"Shao","sequence":"additional","affiliation":[{"name":"Hand Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"4","key":"1","first-page":"6","article-title":"Efficacy of Ilizarov bone transfer combined with intramedullary guide needle technique in the treatment of tibial traumatic bone defect","volume":"36","author":"B. Liu","year":"2020","journal-title":"Chinese Journal of Trauma"},{"issue":"10","key":"2","first-page":"945","article-title":"Application of staged treatment strategy in complex tibia and fibula Gustilo IIIB\/C open fractures with severe soft tissue defect","volume":"34","author":"R. Hu","year":"2018","journal-title":"Zhonghua Trauma Journal"},{"issue":"8","key":"3","first-page":"666","article-title":"Tibial osteotomy and bone transfer for the treatment of large tibial infectious bone defect with soft tissue defect","volume":"20","author":"Y. Q. Xu","year":"2018","journal-title":"Chinese Journal of Orthopaedic Trauma"},{"issue":"10","key":"4","first-page":"1","article-title":"Orthofix unilateral external fixator bone transfer technique for the treatment of large tibial bone defects","volume":"36","author":"Q. Xia","year":"2021","journal-title":"Chinese Journal of Bone and Joint Injury"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jos.2018.06.022"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-019-2927-z"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-021-03950-1"},{"key":"8","article-title":"Efficacy analysis of different external fixation and extension stents in the treatment of long-segment bone defects","author":"G. Wen"},{"issue":"1","key":"9","first-page":"119","article-title":"Clinical analysis of annular external fixator-assisted bone transport in the treatment of traumatic long-segment tibial bone defect","volume":"17","author":"C. K. Zhang","year":"2019","journal-title":"Chinese and Foreign Medical Research"},{"key":"10","volume-title":"Practical Orthopaedic Science","author":"S. T. Xu","year":"2012","edition":"Fourth"},{"issue":"1","key":"11","first-page":"85","article-title":"Bone transfer technology for the treatment of large segmental bone defects in the lower extremity","volume":"20","author":"B. J. Xie","year":"2017","journal-title":"Journal of Clinical Orthopedics"},{"issue":"1","key":"12","first-page":"3","article-title":"Clinical analysis of annular external fixator-assisted bone transport in the treatment of traumatic long-segment tibial bone defects","volume":"17","author":"C. K. Zhang","year":"2019","journal-title":"Chinese and Foreign Medical Research"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-009-0056-9"},{"issue":"9","key":"14","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.2106\/00004623-198769090-00007","article-title":"Fractures of the distal part of the fibula with associated disruption of the deltoid ligament. Treatment without repair of the deltoid ligament","volume":"69","author":"R. A. Baird","year":"1987","journal-title":"The Journal of Bone and Joint Surgery. American Volume"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1177\/107110079401500701"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-020-04503-2"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1097\/BOT.0000000000000982"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jos.2017.12.002"},{"issue":"8","key":"19","first-page":"941","article-title":"Curative effect observation of limb shortening and lengthening in the treatment of tibial infectious bone defect and chronic osteomyelitis","volume":"31","author":"Z. M. Guo","year":"2017","journal-title":"Chinese Journal of Rehabilitation and Reconstruction Surgery"},{"issue":"20","key":"20","first-page":"117","article-title":"Efficacy analysis of unilateral multifunctional external fixator bone transfer in the treatment of post-traumatic osteomyelitis complicated with bone defects of the tibia","volume":"28","author":"F. Zhang","year":"2018","journal-title":"China Journal of Modern Medicine"},{"issue":"2","key":"21","first-page":"97","article-title":"Intramedullary nailing combined with antibiotic-loaded calcium sulfate assisted by Ilizarov ring bone transfer with fixed frame for the treatment of tibial infectious bone defect. Journal of","volume":"48","author":"Y. B. Xu","year":"2021","journal-title":"International Surgery"},{"issue":"7","key":"22","first-page":"862","article-title":"Single-arm external fixator double segmental bone transfer for the treatment of post-traumatic osteomyelitis bone defect in the tibia","volume":"34","author":"Y. Anizier","year":"2020","journal-title":"Chinese Journal of Rehabilitation and Reconstruction Surgery"},{"issue":"5","key":"23","first-page":"473","article-title":"Modified acupuncture at single\/bilateral Renying point in the treatment of vertebral artery type cervical spondylosis and its effect on plasma NPY and UII concentrations","volume":"38","author":"Y. F. Wang","year":"2018","journal-title":"Chinese Acupuncture"},{"issue":"3","key":"24","first-page":"201","article-title":"Comparison of the effects of arthroscopic percutaneous minimally invasive plate fixation and open reduction and internal fixation on knee range of motion, pain stress and inflammatory factors in patients with tibial plateau fractures","volume":"21","author":"W. D. Shi","year":"2019","journal-title":"Journal of Trauma Surgery"},{"issue":"9","key":"25","first-page":"1491","article-title":"Effects of different plate internal fixation techniques on serum SP NPY TNF-\u03b1IL-1\u03b2 levels and knee joint function in patients with tibial plateau fractures","volume":"26","author":"X. F. Yang","year":"2020","journal-title":"Hebei Medicine"},{"issue":"9","key":"26","first-page":"1473","article-title":"Effects of different plate internal fixation techniques on serum SP NPY levels and knee joint function in patients with tibial plateau fractures","volume":"26","author":"P. G. Zhang","year":"2020","journal-title":"Hebei Medicine"},{"key":"27","doi-asserted-by":"crossref","DOI":"10.1093\/milmed\/usy193","article-title":"TNF-\u03b1 stress response is reduced following load carriage training","volume":"184","author":"A. E. Jensen","year":"2019","journal-title":"Military Medicine"},{"issue":"3","key":"28","first-page":"141","article-title":"A role of central alpha-1 adrenergic mechanism in shaking stress-induced acth and noradrenaline secretion[J]","volume":"45","author":"R. Hirasawa","year":"1991","journal-title":"Acta Medica Okayama"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.601519"},{"issue":"31","key":"30","first-page":"5003","article-title":"Bone transfer technique in the treatment of tibial bone defect and changes in serum inflammatory factors: X-ray imaging evaluation","volume":"22","author":"S. Zhang","year":"2018","journal-title":"Chinese Journal of Tissue Engineering Research"},{"issue":"11","key":"31","first-page":"87","article-title":"Comparison of application effects of different treatment schemes in patients with humeral condyle nonunion and bone defect","volume":"27","author":"F. Zheng","year":"2017","journal-title":"China Modern Medical Journal"},{"issue":"5","key":"32","first-page":"379","article-title":"Comparison of the effect of proximal and distal tibial osteotomy and transport in the treatment of tibial osteomyelitis","volume":"22","author":"G. Y. Cheng","year":"2020","journal-title":"Chinese Journal of Orthopaedic Trauma"},{"issue":"20","key":"33","first-page":"1856","article-title":"Comparison of the effect of bone transfer and wrapping bone graft in the treatment of simple tibial large segmental bone defect","volume":"26","author":"J. Liu","year":"2018","journal-title":"Chinese Journal of Orthopaedic Surgery"},{"issue":"32","key":"34","first-page":"61","article-title":"Clinical effect and mechanism of bone transfer in the treatment of tibial fractures complicated with bone defects","volume":"58","author":"Z. G. Wang","year":"2018","journal-title":"Shandong Medicine"}],"updated-by":[{"DOI":"10.1155\/2023\/9852865","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T00:00:00Z","timestamp":1687910400000},"record-id":"47308"},{"DOI":"10.1155\/2023\/9852865","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T00:00:00Z","timestamp":1687910400000}}],"container-title":["Computational and Mathematical Methods in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2022\/9052770.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2022\/9052770.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2022\/9052770.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T20:20:38Z","timestamp":1657916438000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cmmm\/2022\/9052770\/"}},"subtitle":[],"editor":[{"given":"Min","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,7,15]]},"references-count":34,"alternative-id":["9052770","9052770"],"URL":"https:\/\/doi.org\/10.1155\/2022\/9052770","relation":{},"ISSN":["1748-6718","1748-670X"],"issn-type":[{"value":"1748-6718","type":"electronic"},{"value":"1748-670X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7,15]]}}}