{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:19:29Z","timestamp":1740140369901,"version":"3.37.3"},"reference-count":44,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T00:00:00Z","timestamp":1641513600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002799","name":"Capital Medical University","doi-asserted-by":"publisher","award":["YJ-201720","Pz2021019"],"award-info":[{"award-number":["YJ-201720","Pz2021019"]}],"id":[{"id":"10.13039\/501100002799","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research and Cultivation Program of Beijing Municipal Hospital","award":["YJ-201720","Pz2021019"],"award-info":[{"award-number":["YJ-201720","Pz2021019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,1,7]]},"abstract":"<jats:p>Objectives. We aimed to investigate the effects of Shen-Yuan-Dan (SYD), a Chinese medicine preparation, on periprocedural myocardial injury (PMI) and the number of peripheral blood endothelial progenitor cells (EPCs) in patients with unstable angina pectoris (UA) who underwent elective percutaneous coronary intervention (PCI). Methods. Patients were randomly divided into the experimental (group A) and control (group B) groups through the random number table method. In group A, patients concurrently received the conventional western treatment and SYD orally (4 capsules\/time, 3 times\/d, from 3\u2009d before surgery to 7\u2009d after surgery). In group B, patients received conventional Western medicine treatment. Both groups underwent coronary angiography, and patients undergoing PCI were eventually included in the study. The following patient data were collected: incidence of PMI, serum CK-MB content before PCI, 4\u2009h, 24\u2009h, and 7\u2009d after PCI, number of CD45dim\/-CD34+CD309+ peripheral venous EPCs, and number of CD184 coexpressed EPCs. The incidence of adverse reactions and 30-day major adverse cardiovascular events (MACEs) were also recorded. Results. Sixty-two patients were finally included in this study, with 32 and 30 in groups A and B, respectively. In group A, the number of peripheral blood EPCs and the number of CD184 coexpressed EPCs at 1\u2009h before surgery were higher than those at 3\u2009d before surgery (37.24\u2009\u00b1\u200925.20 vs. 22.78\u2009\u00b1\u20099.60\/ml;<jats:inline-formula><a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><a:mi>P<\/a:mi><a:mo>&lt;<\/a:mo><a:mn>0.001<\/a:mn><\/a:math><\/jats:inline-formula>and 23.38\u2009\u00b1\u200915.30 vs. 13.54\u2009\u00b1\u20098.08\/ml;<jats:inline-formula><c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><c:mi>P<\/c:mi><c:mo>&lt;<\/c:mo><c:mn>0.001<\/c:mn><\/c:math><\/jats:inline-formula>, resp.). The number of peripheral blood EPCs and number of CD184 coexpressed EPCs at 4\u2009h after surgery were lower than those at 1\u2009h before surgery (25.30\u2009\u00b1\u200911.90 vs. 37.24\u2009\u00b1\u200925.20\/ml;<jats:inline-formula><e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><e:mi>P<\/e:mi><e:mo>=<\/e:mo><e:mn>0.019<\/e:mn><\/e:math><\/jats:inline-formula>and 15.38\u2009\u00b1\u20098.78 vs. 23.38\u2009\u00b1\u200915.30\/ml;<jats:inline-formula><g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><g:mi>P<\/g:mi><g:mo>=<\/g:mo><g:mn>0.013<\/g:mn><\/g:math><\/jats:inline-formula>, resp.), but there was no difference at 24\u2009h and at 7\u2009d after surgery in comparison with that at 1\u2009h before surgery (<jats:inline-formula><i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><i:mi>P<\/i:mi><i:mo>&gt;<\/i:mo><i:mn>0.05<\/i:mn><\/i:math><\/jats:inline-formula>). In group B, compared with that at 1\u2009h before surgery, there existed a decline in the number of EPCs in peripheral blood and the number of CD184 coexpressed EPCs at 4\u2009h after surgery, but without a statistical difference (<jats:inline-formula><k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><k:mi>P<\/k:mi><k:mo>&gt;<\/k:mo><k:mn>0.05<\/k:mn><\/k:math><\/jats:inline-formula>). Comparing both groups, it was found that the incidence of PMI in group A was lower (6.25% vs. 26.67%;<jats:inline-formula><m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><m:mi>P<\/m:mi><m:mo>=<\/m:mo><m:mn>0.04<\/m:mn><\/m:math><\/jats:inline-formula>), and the serum CK-MB content at 4 and 24\u2009h after surgery was also lower than that in group B (17.33\u2009\u00b1\u20095.83 vs. 20.38\u2009\u00b1\u20094.32 U\/l;<jats:inline-formula><o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><o:mi>P<\/o:mi><o:mo>=<\/o:mo><o:mn>0.048<\/o:mn><\/o:math><\/jats:inline-formula>and 15.79\u2009\u00b1\u20095.32 vs. 19.10\u2009\u00b1\u20094.93 U\/l;<jats:inline-formula><q:math xmlns:q=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><q:mi>P<\/q:mi><q:mo>=<\/q:mo><q:mn>0.030<\/q:mn><\/q:math><\/jats:inline-formula>, resp.). The number of EPCs in peripheral blood and the number of CD184 coexpressed EPCs in group A were higher than those in group B at 1\u2009h before surgery (37.24\u2009\u00b1\u200925.20 vs. 22.36\u2009\u00b1\u200912.26\/ml;<jats:inline-formula><s:math xmlns:s=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\"><s:mi>P<\/s:mi><s:mo>=<\/s:mo><s:mn>0.034<\/s:mn><\/s:math><\/jats:inline-formula>and 23.38\u2009\u00b1\u200915.30 vs. 13.12\u2009\u00b1\u200914.62\/ml;<jats:inline-formula><u:math xmlns:u=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\"><u:mi>P<\/u:mi><u:mo>=<\/u:mo><u:mn>0.013<\/u:mn><\/u:math><\/jats:inline-formula>, resp.). In addition, there were no obvious adverse reactions and no 30-day MACEs in both groups during the trial. Conclusion. SYD can reduce PMI and promote the mobilization of EPCs in the perioperative period of elective PCI in patients with UA.<\/jats:p>","DOI":"10.1155\/2022\/9055585","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T17:35:16Z","timestamp":1641576916000},"page":"1-10","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Shen-Yuan-Dan on Periprocedural Myocardial Injury and the Number of Peripheral Blood Endothelial Progenitor Cells in Patients with Unstable Angina Pectoris Undergoing Elective Percutaneous Coronary Intervention"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0078-7873","authenticated-orcid":true,"given":"Zhenmin","family":"Zhang","sequence":"first","affiliation":[{"name":"Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenlong","family":"Xing","sequence":"additional","affiliation":[{"name":"Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxu","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyi","family":"Liu","sequence":"additional","affiliation":[{"name":"Capital Medical University, Beijing 100069, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2785-7595","authenticated-orcid":true,"given":"Juju","family":"Shang","sequence":"additional","affiliation":[{"name":"Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1161\/circinterventions.118.006901"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gheart.2018.08.004"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab271"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx799"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.22962"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000137828.06205.87"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.02.025"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2015.10.043"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2013.09.012"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2018.09.44"},{"issue":"8","key":"11","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.3760\/cma.j.issn.0366-6999.20122355","article-title":"Transplantation of human umbilical cord-derived endothelial progenitor cells promotes re-endothelialization of the injured carotid artery after balloon injury in New Zealand white rabbits","volume":"126","author":"C. 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