{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:16:29Z","timestamp":1767168989791,"version":"build-2238731810"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T00:00:00Z","timestamp":1658361600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2022,7,21]]},"abstract":"\n Objective. Hirschsprung disease (HSCR) is a serious congenital intestinal disease with a prevalence of 1\/5000. HSCR remains one of the most severe congenital malformations of the abdominal organs in children that require complex reconstructive surgery. This study is aimed at investigating the clinical analysis of ileal Santulli stoma and ileal double-lumen stoma in children diagnosed with intestinal neuronal dysplasia (IND). Methods. Retrospective analysis was performed on the children who were admitted to our hospital for intestinal obstruction from January 2014 to January 2019, underwent fistula operation and fistula closure operation, and were diagnosed with IND. According to the different modes of fistula, the children were divided into ileal Santulli stoma group and ileal double-lumen stoma group. The body weight of the children in the two groups during the second stage of fistula closure operation was compared. The number of hospitalizations due to enteritis and dehydration during the two operations was compared. Results. A total of 23 cases (12 males and 11 females) were included in this study, including 10 cases in the Santulli group and 13 cases in the ileal double-lumen stoma group. There were no significant differences in baseline data and fistula location between the two groups. Compared with the ileal double-lumen stoma group, the Santulli stoma group had significantly higher weight of fistula precursor (\n \n \n P<\/a:mi>\n <<\/a:mo>\n 0.05<\/a:mn>\n <\/a:math>\n <\/jats:inline-formula>\n ), the interval between two operations was shorter (\n \n \n P<\/c:mi>\n <<\/c:mo>\n 0.05<\/c:mn>\n <\/c:math>\n <\/jats:inline-formula>\n ), there is less hospitalization for enteritis and dehydration during the two operations (\n \n \n P<\/e:mi>\n <<\/e:mo>\n 0.05<\/e:mn>\n <\/e:math>\n <\/jats:inline-formula>\n ), and there is less economic cost after fistula (\n \n \n P<\/g:mi>\n <<\/g:mo>\n 0.05<\/g:mn>\n <\/g:math>\n <\/jats:inline-formula>\n ). Conclusion. The clinical effect of ileum Santulli fistula is significantly better than double-lumen ileum fistula, which is not only beneficial to the growth and development of children after the first fistula but also can shorten the time of fistula closure, reduce the incidence of dehydration, and reduce the economic burden of family members. Therefore, it is worthy of clinical promotion and application.\n <\/jats:p>","DOI":"10.1155\/2022\/9165651","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T12:35:48Z","timestamp":1658406948000},"page":"1-5","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of Outcomes between Two Surgical Techniques for Patients with Intestinal Neuronal Dysplasia"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6445-6603","authenticated-orcid":true,"given":"Yu","family":"Lin","sequence":"first","affiliation":[{"name":"Pediatric Surgery Department, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, 350000 Fujian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dianming","family":"Wu","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Department, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, 350000 Fujian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Shen","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Department, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, 350000 Fujian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanbin","family":"He","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Department, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, 350000 Fujian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6118-8583","authenticated-orcid":true,"given":"Jianxin","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery 2 Section, The First Hospital Affiliated to Fujian Medical University, Fuzhou, 350000 Fujian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.semcdb.2017.01.006","article-title":"Enteric nervous system development: a crest cell\u2019s journey from neural tube to colon","volume":"66","author":"N. 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