{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:29:56Z","timestamp":1791653396870,"version":"4.3.4"},"reference-count":55,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T00:00:00Z","timestamp":1669334400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Endocrinology"],"published-print":{"date-parts":[[2022,11,25]]},"abstract":"<jats:p>Background. Acute Sheehan\u2019s syndrome is rare, as well as hyponatremia as its initial manifestation. In addition, spontaneous pregnancy in patients after Sheehan\u2019s syndrome is unusual. To our knowledge, no cases of spontaneous pregnancy after acute Sheehan\u2019s syndrome have been reported. We describe a case of Sheehan\u2019s syndrome that presented with acute hyponatremia and a spontaneous pregnancy. Case. A 34-year-old female developed blood loss during delivery, which required a blood transfusion. On day seven postpartum, she presented with headaches, lethargy, and difficulty in breastfeeding. The workup showed hyponatremia (118\u2009mEq\/l), secondary hypothyroidism, and low prolactin levels. Magnetic resonance imaging showed pituitary necrosis. She was treated with NaCl, hydrocortisone (cortisol results were not available), and levothyroxine. Laboratory tests six weeks after discharge showed low IGF-1 and 8 AM cortisol and normal FT4, LH, FSH, and PRL levels. She was able to partially breastfeed until 4 months postpartum. Regular menstrual cycles started three months later. She became spontaneously pregnant one year later. Conclusion. Acute Sheehan\u2019s syndrome should be considered in the evaluation of postpartum patients with suggestive symptoms. Physicians should be aware that hyponatremia could be an initial manifestation of Sheehan\u2019s syndrome, which requires a high index of suspicion for diagnosis. Spontaneous pregnancy can occur after acute Sheehan\u2019s syndrome.<\/jats:p>","DOI":"10.1155\/2022\/9181365","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T16:48:28Z","timestamp":1669394908000},"page":"1-11","source":"Crossref","is-referenced-by-count":9,"title":["Acute Sheehan\u2019s Syndrome Presenting with Hyponatremia Followed by a Spontaneous Pregnancy"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2083-7839","authenticated-orcid":true,"given":"Maria M.","family":"Pineyro","sequence":"first","affiliation":[{"name":"Clinica de Endocrinolog\u00eda y Metabolismo, Hospital de Cl\u00ednicas, Facultad de Medicina, Universidad de la Rep\u00fablica, Montevideo, Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8156-1269","authenticated-orcid":true,"given":"Leonardo","family":"Diaz","sequence":"additional","affiliation":[{"name":"Clinica de Endocrinolog\u00eda y Metabolismo, Hospital de Cl\u00ednicas, Facultad de Medicina, Universidad de la Rep\u00fablica, Montevideo, Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7444-5809","authenticated-orcid":true,"given":"Macarena","family":"Guzzetti","sequence":"additional","affiliation":[{"name":"Clinica de Endocrinolog\u00eda y Metabolismo, Hospital de Cl\u00ednicas, Facultad de Medicina, Universidad de la Rep\u00fablica, Montevideo, Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2735-2933","authenticated-orcid":true,"given":"Mariana","family":"Risso","sequence":"additional","affiliation":[{"name":"Clinica de Endocrinolog\u00eda y Metabolismo, Hospital de Cl\u00ednicas, Facultad de Medicina, Universidad de la Rep\u00fablica, Montevideo, Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4740-2969","authenticated-orcid":true,"given":"Jimena","family":"Pereda","sequence":"additional","affiliation":[{"name":"Clinica de Endocrinolog\u00eda y Metabolismo, Hospital de Cl\u00ednicas, Facultad de Medicina, Universidad de la Rep\u00fablica, Montevideo, Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-017-1380-y"},{"key":"2","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1023\/B:PITU.0000023425.20854.8e","article-title":"Sheehan's syndrome","volume":"6","author":"F. 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