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Progressive NAFLD leads to nonalcoholic steatohepatitis (NASH) and ultimately causes cirrhosis and hepatocellular carcinoma, and NASH is currently a frequent cause of liver transplantation. Oxidative stress is often contributed to the progression of NAFLD, and hence, antioxidants such as silymarin, silybin, or silibinin, pentoxifylline, resveratrol, and vitamins A, C, and E are used in clinical trials against NAFLD. Silymarin induces the peroxisome proliferator\u2010activated receptor\n                    <jats:italic>\u03b1<\/jats:italic>\n                    (PPAR\n                    <jats:italic>\u03b1<\/jats:italic>\n                    ), a fatty acid sensor, which promotes the transcription of genes that are required for the enzymes involved in lipid oxidation in hepatocytes. Silybin inhibits sterol regulatory element\u2010binding protein 1 and carbohydrate response element\u2010binding protein to downregulate the expression of genes responsible for de novo lipogenesis by activating AMP\u2010activated protein kinase phosphorylation. Pentoxifylline inhibits TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    expression and endoplasmic reticulum stress\u2010mediated inflammatory nuclear factor kappa B (NF\u2010\n                    <jats:italic>\u03ba<\/jats:italic>\n                    B) activation. Thus, it prevents NAFLD to NASH progression. Resveratrol inhibits methylation at Nrf\u20102 promoters and NF\u2010\n                    <jats:italic>\u03ba<\/jats:italic>\n                    B activity via SIRT1 activation in NAFLD conditions. However, clinically, resveratrol has not shown promising beneficial effects. Vitamin C is beneficial in NAFLD patients. Vitamin E is not effectively regressing hepatic fibrosis. Hence, its combination with antifibrotic agents is used as an adjuvant to produce a synergistic antifibrotic effect. However, to date, none of these antioxidants have been used as a definite therapeutic agent in NAFLD patients. Further, these antioxidants should be studied in NAFLD patients with larger populations and multiple endpoints in the future.\n                  <\/jats:p>","DOI":"10.1155\/2022\/9233650","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T19:35:13Z","timestamp":1652297713000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["A Molecular Insight into the Role of Antioxidants in Nonalcoholic Fatty Liver 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