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This study included 6 bedridden patients with thoracolumbar spondylodiscitis without deformity formation. All 6 patients were treated with the VSD in our hospital from June 30, 2018, to August 31, 2019. All 6 cases of thoracolumbar infection achieved clinical cure at 3\u2010month follow\u2010up, and no surgical\u2010related mortalities occurred in our series. One patient died of acute cerebral infarction 5 months after surgery, and the remaining 5 patients completed a 12\u2010month follow\u2010up without recurrence. The JOA score of all 6 cases improved significantly after VSD treatment. VSD is feasible for safe and effective treatment for primary thoracolumbar infection. 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