{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:25:41Z","timestamp":1767169541686,"version":"build-2238731810"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2022,9,14]]},"abstract":"<jats:p>\n                    Background. Gastric cancer pathological biopsy and visual examination have been the gold standard for gastric cancer diagnosis, but their operation is costly, demanding, and risky, so it is especially important to find an effective examination method in clinical practice. Aims. To investigate the correlation between serum pepsinogen I (PGI), pepsinogen II (PGII), pepsinogen I and II ratio (PGR), IL-6, and TNF-\u03b1 and Helicobacter pylori (Hp) infection in patients with gastric cancer. Materials and Methods. Fifty patients with Hp-infected gastric cancer admitted to the Department of Gastroenterology of our hospital from January 2019 to December 2021 were selected for the study as the observation group, and another 50 patients without Hp-infected gastric cancer were selected as the comparison group to compare the correlation analysis of PGI, PGII, PGR, IL-6, and TNF-\u03b1 with Hp infection between the two groups after admission and treatment. Results. After measurement, PGI and PGII in the observation group were significantly lower than those in the comparison group, and TNF-\u03b1, IL-18, and IL-6 in the observation group were significantly higher than those in the comparison group, and the comparative differences were all statistically significant (\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    ). The results of multivariate logistic regression model analysis of independent risk factors for gastric cancer showed that IL-18, hs-CRP, and tumor necrosis factor- (TNF-) \u03b1 were risk factors for Hp infection in gastric cancer. Conclusion. The expression of IL-18, hs-CRP, and TNF-\u03b1 factors in Hp-infected gastric cancer patients is correlated. IL-6, IL-18, and TNF-\u03b1 are involved in the entire process from the onset to the development of Hp-positive gastric mucosal inflammation in patients, which is of great value in the diagnosis of gastric cancer and helps to assess the degree of progression and prognosis of gastric cancer.\n                  <\/jats:p>","DOI":"10.1155\/2022\/9277847","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T21:20:30Z","timestamp":1663190430000},"page":"1-7","source":"Crossref","is-referenced-by-count":4,"title":["Correlation Analysis of Serum Pepsinogen, Interleukin, and TNF-\u03b1 with Hp Infection in Patients with Gastric Cancer: A Randomized Parallel Controlled Clinical Study"],"prefix":"10.1155","volume":"2022","author":[{"given":"Shunxin","family":"Hao","sequence":"first","affiliation":[{"name":"Department of General Surgery, Wuhan University of Science and Technology Hospital, 430065, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minyue","family":"Shou","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Nanjing Medical University (Department of Oncology), 210029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Ma","sequence":"additional","affiliation":[{"name":"Zhongshan Hospital Affiliated to Fudan University, 200032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongqian","family":"Shu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Nanjing Medical University (Department of Oncology), 210029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8970-399X","authenticated-orcid":true,"given":"Yuanyuan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Wuhan Hospital of Traditional Chinese Medicine, 49 Lihuangpi Road, Jiangan District, Wuhan City, Hubei Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.16194"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3390\/medicina55090543"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1177\/0192623311431466"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2020.61.4.317"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001566"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.02.008"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1097\/JCMA.0000000000000519"},{"key":"8","volume-title":"Hysteroscopy and Atlas","author":"X. 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