{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T23:13:02Z","timestamp":1780528382846,"version":"3.54.1"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T00:00:00Z","timestamp":1664841600000},"content-version":"vor","delay-in-days":276,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100438"],"award-info":[{"award-number":["82100438"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81900248"],"award-info":[{"award-number":["81900248"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Right ventricular (RV) failure determines the prognosis in pulmonary arterial hypertension (PAH), but the underlying mechanism is still unclear. Growing evidence has shown that microRNAs participate in RV remodeling. This study is undertaken to explore the role of miR\u2010335\u20105p in regulating RV remodeling induced by PAH. Two PAH models were used in the study, including the monocrotaline rat model and hypoxia\/su5416 mouse model. miRNA sequencing and RT\u2010qPCR validation identified that miR\u2010335\u20105p was elevated in the RV of PAH rats. In vitro, miR\u2010335\u20105p expression was increased after angiotensin II treatment, and miR\u2010335\u20105p inhibition relieved angiotensin II\u2010induced cardiomyocyte hypertrophy. The luciferase reporter assay showed that calumenin was a target gene for miR\u2010335\u20105p. Pretreatment with miR\u2010335\u20105p inhibitors could rescue calumenin downregulation induced by angiotensin II in H9C2 cells. Moreover, intracellular Ca<jats:sup>2+<\/jats:sup> concentration and apoptosis were increased after angiotensin II treatment, and miR\u2010335\u20105p inhibition decreased intracellular Ca<jats:sup>2+<\/jats:sup> accumulation and apoptosis. Finally, in vivo miR\u2010335\u20105p downregulation (antagomir miR\u2010335\u20105p) attenuated RV remodeling and rescued calumenin downregulation under conditions of hypoxia\/su5416 exposure. Our work highlights the role of miR\u2010335\u20105p and calumenin in RV remodeling and may lead to the development of novel therapeutic strategies for right heart failure.<\/jats:p>","DOI":"10.1155\/2022\/9294148","type":"journal-article","created":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T03:20:14Z","timestamp":1664940014000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Upregulation of miR\u2010335\u20105p Contributes to Right Ventricular Remodeling via Calumenin in Pulmonary Arterial 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