{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:45:04Z","timestamp":1792079104226,"version":"4.4.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T00:00:00Z","timestamp":1649980800000},"content-version":"vor","delay-in-days":104,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"This work was supported by a grant-in-aid for scientific research","award":["JP20K10219"],"award-info":[{"award-number":["JP20K10219"]}]},{"name":"This work was supported by a grant-in-aid for scientific research","award":["JP19K18280"],"award-info":[{"award-number":["JP19K18280"]}]},{"name":"This work was supported by a grant-in-aid for scientific research","award":["JP16K11670"],"award-info":[{"award-number":["JP16K11670"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Dentistry"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . Denosumab, a human monoclonal antibody against receptor activator of nuclear factor\u2010kappa B ligand (RANKL), is a novel bone antiresorptive agent used in patients with osteoporosis or metastatic bone cancer. Denosumab\u2010related osteonecrosis of the jaw (DRONJ) has been recently reported in patients using denosumab. However, the mechanisms of DRONJ are not fully understood. Appropriate pathogenic mechanisms of DRONJ have yet to be established. Therefore, we investigated the pathogenesis of DRONJ in mice.\n                    <jats:italic>Methods<\/jats:italic>\n                    . Anti\u2010mouse RANKL monoclonal antibody and melphalan were performed to create a mouse model of DRONJ\u2010like lesions in female C57BL\/6J mice. We examined the development of DRONJ\u2010like lesions and immune function.\n                    <jats:italic>Results<\/jats:italic>\n                    . We showed that administration of anti\u2010mouse RANKL monoclonal antibody and melphalan caused DRONJ\u2010like lesions that recapitulated major clinical manifestations of the human disease, including the characteristic features of an open alveolar socket and exposed necrotic bone. In the analysis using a mouse model of DRONJ\u2010like lesion, it was revealed that anti\u2010mouse RANKL monoclonal antibody and melphalan suppress autoimmune regulator (AIRE) expression in the thymus and imbalanced T cell populations.\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . This study suggests evidence of an immunity\u2010based mechanism of DRONJ\u2010like disease. This work may contribute to a better understanding of the pathogenesis of human DRONJ.\n                  <\/jats:p>","DOI":"10.1155\/2022\/9299602","type":"journal-article","created":{"date-parts":[[2022,4,16]],"date-time":"2022-04-16T01:35:09Z","timestamp":1650072909000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Anti\u2010RANKL Inhibits Thymic Function and Causes DRONJ in 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