{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:06:35Z","timestamp":1767168395113,"version":"build-2238731810"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T00:00:00Z","timestamp":1661817600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"2021 Hebei Medical Science Research Project Plan","award":["20211366"],"award-info":[{"award-number":["20211366"]}]},{"name":"2021 Hebei Medical Science Research Project Plan","award":["072761740"],"award-info":[{"award-number":["072761740"]}]},{"name":"2007 Hebei Science and Technology Support Project Plan","award":["20211366"],"award-info":[{"award-number":["20211366"]}]},{"name":"2007 Hebei Science and Technology Support Project Plan","award":["072761740"],"award-info":[{"award-number":["072761740"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Scanning"],"published-print":{"date-parts":[[2022,8,30]]},"abstract":"\n In order to explore the changes and clinical significance of serum TNF-\u03b1 and IL-6 and ET levels in the pathogenesis of hypertensive disorders of pregnancy (HDIP), echocardiography, and serum IL-6 and TNF-\u03b1 changes in pregnant women with a hypertensive disorder, a clinical analysis method was proposed. A retrospective analysis of 59 pregnant women who visited the obstetrics department of a provincial hospital was divided into 2 groups. The normal control group consisted of 32 normal, uncomplicated pregnant women; the preeclampsia group included 27 patients with systolic blood\n \n \n pressure<\/a:mtext>\n ><\/a:mo>\n 140<\/a:mn>\n \u2009<\/a:mtext>\n mmHg<\/a:mtext>\n <\/a:math>\n <\/jats:inline-formula>\n and\/or diastolic blood\n \n \n pressure<\/c:mtext>\n ><\/c:mo>\n 90<\/c:mn>\n \u2009<\/c:mtext>\n mmHg<\/c:mtext>\n <\/c:math>\n <\/jats:inline-formula>\n who developed proteinuria after 20 weeks of gestation. The levels of TNF-\u03b1 and IL-6 in serum of normal pregnant women and pregnant women with preeclampsia were detected by enzyme-linked immunosorbent assay (ELISA). The results showed that compared with normal pregnant women, the serum levels of TNF-\u03b1 and IL-6 in the early pregnant women of Zizhi were significantly increased, and the trend of increased TNF-\u03b1 and IL-6 levels was related to the severity of complications. With the mean pulmonary artery\n \n \n pressure<\/e:mtext>\n ><\/e:mo>\n 50<\/e:mn>\n \u2009<\/e:mtext>\n mmHg<\/e:mtext>\n <\/e:math>\n <\/jats:inline-formula>\n , the serum TNF-\u03b1 level of pregnant women was significantly higher than that of pregnant women with mean pulmonary artery\n \n \n pressure<\/g:mtext>\n <<\/g:mo>\n 50<\/g:mn>\n \u2009<\/g:mtext>\n mmHg<\/g:mtext>\n <\/g:math>\n <\/jats:inline-formula>\n . The analysis found that the serum levels of TNF-\u03b1 and IL-6 in patients with hypoxic gestational hypertension were significantly increased, and the results of lung tissue immunohistochemistry also showed that serum TNF-\u03b1 and IL-6 levels in patients with hypoxic gestational hypertension were significantly increased. And serum TNF-\u03b1 and IL-6 levels were positively correlated with right ventricular systolic blood pressure (RVSP). Conclusion. This study revealed that the elevated levels of serum TNF-\u03b1 and IL-6 are closely related to the pathophysiological process of gestational hypertension. Serum levels of TNF-\u03b1 and IL-6 and ET were significantly increased, and the changes of serum TNF-\u03b1 and IL-6 and ET levels had important clinical value for closely monitoring the severity of the disease and the development of the disease.\n <\/jats:p>","DOI":"10.1155\/2022\/9299746","type":"journal-article","created":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T20:05:13Z","timestamp":1661889913000},"page":"1-7","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Analysis of Echocardiography and Serum IL-6 and TNF-\u03b1 Changes in Pregnant Women with Hypertension"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7336-8733","authenticated-orcid":true,"given":"Ying","family":"Liu","sequence":"first","affiliation":[{"name":"Obstetrical Department VIII, The Fourth Hospital of Shijiazhuang (The Obstetrics and Gynecology Hospital of Hebei Medical University), Shijiazhuang, Hebei 050000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4540-7982","authenticated-orcid":true,"given":"Xiaolin","family":"Hou","sequence":"additional","affiliation":[{"name":"Prenatal Diagnosis Center, The Fourth Hospital of Shijiazhuang (The Obstetrics and Gynecology Hospital of Hebei Medical University), Shijiazhuang, Hebei 050000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9941-5294","authenticated-orcid":true,"given":"Mei","family":"Yu","sequence":"additional","affiliation":[{"name":"Prenatal Diagnosis Center, The Fourth Hospital of Shijiazhuang (The Obstetrics and Gynecology Hospital of Hebei Medical University), Shijiazhuang, Hebei 050000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1440-3949","authenticated-orcid":true,"given":"Jin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Health Care Center, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060520934288"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1080\/10641955.2020.1818090"},{"issue":"3","key":"3","first-page":"315","article-title":"Lung ultrasound in a covid pandemic choosing wisely","volume":"20","author":"D. 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