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Its abnormal expression and dysfunction have been reported in solid tumor and hematopoietic malignancies. Here, we reported that suppression of NHE1 in BCR\u2010ABL<jats:sup>+<\/jats:sup> hematopoietic malignancies\u2019 K562 cells treated with Etoposide was manipulated by miR\u201019 and c\u2010MYC. Inhibition of miR\u201019 or c\u2010MYC enhanced the expression of NHE1 and sensitized K562 cells to Etoposide <jats:italic>in vitro<\/jats:italic>. The <jats:italic>in vivo<\/jats:italic> nude mouse transplantation model was also performed to confirm the enhanced sensitivity of K562 cells to Etoposide by inhibiting the miR\u201019 or c\u2010MYC pathway. TCGA analysis conferred a negative correlation between miR\u201019 level and leukemia patients\u2019 survival. Thus, our results provided a potential management by which the c\u2010MYC\u2010miRNA 19 pathway might have a crucial impact on sensitizing K562 cells to Etoposide in the therapeutic approaches.<\/jats:p>","DOI":"10.1155\/2022\/9306614","type":"journal-article","created":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T19:50:06Z","timestamp":1658605806000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Inhibition of c\u2010MYC\u2010miRNA 19 Pathway Sensitized CML K562 Cells to Etoposide via NHE1 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