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While intended to reverse ischemia, reperfusion can further aggravate an ischemic injury (ischemia\u2010reperfusion injury, I\/R injury) through a range of pathologic processes. An I\/R injury to one organ can also harm other organs, leading to systemic multiorgan failure. A type of carotenoid, lycopene, has been shown to treat and prevent many diseases (e.g., rheumatoid arthritis, cancer, diabetes, osteoporosis, male infertility, neurodegenerative diseases, and cardiovascular disease), making it a hot research topic in health care. Some recent researches have suggested that lycopene can evidently ameliorate ischemic and I\/R injuries to many organs, but few clinical studies are available. 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