{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T19:56:41Z","timestamp":1793390201697,"version":"4.5.0"},"reference-count":51,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T00:00:00Z","timestamp":1645488000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"MVZ Daniel Garz\u00f3n Biom\u00e9dicas"},{"name":"MVZ H\u00e9ctor Malagon"},{"DOI":"10.13039\/501100005739","name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005739","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Daniela Rodriguez Monta\u00f1o IFC Histologia"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2022,2,22]]},"abstract":"Obesity and dyslipidemias are both signs of metabolic syndrome, usually associated with ventricular arrhythmias. Here, we tried to identify cardiac electrical alteration and biomarkers in nonobese rats with metabolic syndrome (MetS), and these findings might lead to more lethal arrhythmias than obese animals. The MetS model was developed in Wistar rats with high-sucrose diet (20%), and after twenty-eight weeks were obtained two subgroups: obese (OMetS) and nonobese (NOMetS). The electrocardiogram was used to measure the ventricular arrhythmias and changes in the heart rate variability. Also, we measured ventricular hypertrophy and its relationship with electrical activity alterations of both ventricles, using micro-electrode and voltage clamp techniques. Also, we observed alterations in the contraction force of ventricles where a transducer was used to record mechanical and electrical papillary muscle, simultaneously. Despite both subgroups presenting long QT syndrome (\n \n 0.66<\/a:mn>\n \u00b1<\/a:mo>\n 0.05<\/a:mn>\n <\/a:math>\n <\/jats:inline-formula> and \n \n 0.66<\/c:mn>\n \u00b1<\/c:mo>\n 0.07<\/c:mn>\n <\/c:math>\n <\/jats:inline-formula>\u2009ms with respect to the \n \n control<\/e:mtext>\n \u2009<\/e:mtext>\n 0.55<\/e:mn>\n \u00b1<\/e:mo>\n 0.1<\/e:mn>\n <\/e:math>\n <\/jats:inline-formula>\u2009ms), the changes in the heart rate variability were present only in OMetS, while the NOMetS subgroup presented changes in QT interval variability (NOMetS \n \n SD<\/g:mtext>\n =<\/g:mo>\n 1.8<\/g:mn>\n <\/g:math>\n <\/jats:inline-formula>, \n \n SD<\/i:mtext>\n 2<\/i:mn>\n =<\/i:mo>\n 2.8<\/i:mn>\n <\/i:math>\n <\/jats:inline-formula>; \n \n SD<\/k:mtext>\n 1<\/k:mn>\n \/<\/k:mo>\n SD<\/k:mtext>\n 2<\/k:mn>\n =<\/k:mo>\n 0.75<\/k:mn>\n <\/k:math>\n <\/jats:inline-formula>). Also, the NOMetS revealed tachycardia (10%; \n \n p<\/m:mi>\n <<\/m:mo>\n 0.05<\/m:mn>\n <\/m:math>\n <\/jats:inline-formula>) with changes in action potential duration (63% in the right papillary and 50% in the left papillary) in the ventricular papillary which are correlated with certain alterations in the potassium currents and the force of contraction. The OMetS showed an increase in action potential duration and the force of contraction in both ventricles, which are explained as bradycardia. Our results revealed lethal arrhythmias in both MetS subgroups, irrespectively of the presence of obesity. Consequently, the NOMetS showed mechanical-electrical alterations regarding ventricle hypertrophy that should be at the NOMetS, leading to an increase of CV mortality.<\/jats:p>","DOI":"10.1155\/2022\/9321445","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T22:05:07Z","timestamp":1645567507000},"page":"1-10","source":"Crossref","is-referenced-by-count":7,"title":["Ventricular Dysfunction in Obese and Nonobese Rats with Metabolic Syndrome"],"prefix":"10.1155","volume":"2022","author":[{"given":"Julian","family":"Torres-Jacome","sequence":"first","affiliation":[{"name":"Laboratorio de Fisiopatolog\u00eda Cardiovascular, Instituto de Ciencias, Benem\u00e9rita Universidad Aut\u00f3noma de Puebla, Puebla, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian Sabino","family":"Ortiz-Fuentes","sequence":"additional","affiliation":[{"name":"Laboratorio de Fisiopatolog\u00eda Cardiovascular, Instituto de Ciencias, Benem\u00e9rita Universidad Aut\u00f3noma de Puebla, Puebla, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Bernabe-Sanchez","sequence":"additional","affiliation":[{"name":"Laboratorio de Fisiopatolog\u00eda Cardiovascular, Instituto de Ciencias, Benem\u00e9rita Universidad Aut\u00f3noma de Puebla, Puebla, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Lopez-Silva","sequence":"additional","affiliation":[{"name":"Laboratorio de Fisiopatolog\u00eda Cardiovascular, Instituto de Ciencias, Benem\u00e9rita Universidad Aut\u00f3noma de Puebla, Puebla, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myrian","family":"Velasco","sequence":"additional","affiliation":[{"name":"Neuroscience Division, Instituto de Fisiolog\u00eda Celular, Department of Cognitive Neuroscience, Universidad Nacional Aut\u00f3noma de M\u00e9xico, M\u00e9xico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha Lucia","family":"Ita-Amador","sequence":"additional","affiliation":[{"name":"Laboratorio de Fisiopatolog\u00eda Cardiovascular, Complejo Nororiental, Benem\u00e9rita Universidad Aut\u00f3noma de Puebla, Puebla, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4725-7714","authenticated-orcid":true,"given":"Alondra","family":"Albarado-Iba\u00f1ez","sequence":"additional","affiliation":[{"name":"Laboratorio de Fisiopatolog\u00eda Cardiovascular, Instituto de Ciencias, Benem\u00e9rita Universidad Aut\u00f3noma de Puebla, Puebla, Mexico"},{"name":"Laboratorio de Aplicaciones Biotecnol\u00f3gicas, Instituto de Ciencias, Benem\u00e9rita Universidad Aut\u00f3noma de Puebla, Puebla, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.4.683"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(88)90402-0"},{"key":"3","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.numecd.2019.05.066","article-title":"Central and peripheral body fat distribution: different associations with low-grade inflammation in young adults?","volume":"29","author":"M. 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