{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T15:27:15Z","timestamp":1759159635317,"version":"3.44.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T00:00:00Z","timestamp":1643587200000},"content-version":"vor","delay-in-days":30,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Clinical Practice"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. Raynaud\u2019s phenomenon (RP) is a multifactorial disorder. If any underlying disease cannot be determined to be responsible for RP, then it is considered to be the primary RP (pRP). We aimed to investigate the differences between laboratory markers and impaired endothelial function in pRP. <jats:italic>Materials and Methods<\/jats:italic>. Forty\u2010two pRP patients and 30 healthy individuals were included as the study and control groups, respectively. The endothelial function was evaluated with flow\u2010mediated dilatation (FMD) of the brachial artery. The blood samples were obtained from both groups, and white blood cell (WBC), hemoglobin, platelets, mean platelet volume (MPV), creatinine, alanine aminotransferase (ALT), aspartate aminotransferase (AST), D\u2010dimer, fibrinogen, albumin, fibrinogen\u2010to\u2010albumin ratio (FAR), neutrophil\u2010to\u2010lymphocyte ratio (NLR), D\u2010dimer\u2010to\u2010albumin ratio (DDAR), and monocyte chemoattractant protein\u20101 (MCP\u20101) parameters were studied. The blood parameters and FMD values obtained were compared between groups. <jats:italic>Results<\/jats:italic>. The groups were similar in regard to age, gender, and smoking history (<jats:italic>p<\/jats:italic> &lt; 0.05). There was no difference between the two groups in regard to hemoglobin, platelet, MPV, creatinine, ALT, D\u2010dimer, albumin, FAR, NLR, and DDAR levels (<jats:italic>p<\/jats:italic> &lt; 0.05). AST levels were slightly higher in the pRP group (<jats:italic>p<\/jats:italic> = 0.027). Markedly increased WBC, fibrinogen, MPV, and MCP\u20101 values were detected in the pRP group (<jats:italic>p<\/jats:italic> = 0.001), as well as higher abnormal FMD responses (<jats:italic>p<\/jats:italic> = 0.001). There was a direct correlation between abnormal FMD response and serum MCP\u20101 values in patients with pRP (<jats:italic>R<\/jats:italic>: 0.308, <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>: 0.095, <jats:italic>p<\/jats:italic>: 0.044). <jats:italic>Conclusion<\/jats:italic>. It seems to be that MCP\u20101 levels are higher in patients with pRP, and increased values of MCP\u20101 levels seem to be related to impaired endothelial functions.<\/jats:p>","DOI":"10.1155\/2022\/9347946","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T06:39:26Z","timestamp":1644388766000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Association of Flow\u2010Mediated Dilatation and Blood Parameters in Primary Raynaud\u2019s Phenomenon"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3570-5361","authenticated-orcid":false,"given":"S\u00fcheyla","family":"Uzun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6222-2133","authenticated-orcid":false,"given":"\u0130lker","family":"Kaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,31]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2017.14506"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-0386-4"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2010.09.008"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/occmed\/kqy053"},{"key":"e_1_2_9_5_2","first-page":"123","article-title":"A review of Raynaud\u2019s disease","volume":"113","author":"Temprano K. 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