{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T21:46:38Z","timestamp":1774907198999,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,2,12]],"date-time":"2022-02-12T00:00:00Z","timestamp":1644624000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020206","name":"Health Commission of Shandong Province","doi-asserted-by":"publisher","award":["202004070866"],"award-info":[{"award-number":["202004070866"]}],"id":[{"id":"10.13039\/501100020206","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Healthcare Engineering"],"published-print":{"date-parts":[[2022,2,12]]},"abstract":"<jats:p>Background. Osteonecrosis of the femoral head (ONFH) is a common hip joint disease, which is more harmful and seriously affects the lives of patients. This study aims to clarify the regulatory mechanism of lncRNA FGD5-AS1 in ONFH. Methods. The expression of the protein and mRNA was detected by RT-qPCR and Western blot assay. The regulatory mechanism of lncRNA FGD5-AS1 was detected by the dual-luciferase reporter assay, CCK-8 assay, and flow cytometry assay. Results. Dex can inhibit cell proliferation and differentiation and induce apoptosis in hBMSCs in a dose-dependent manner. Overexpression of lncRNA FGD5-AS1 promoted cell proliferation and restrained apoptosis in Dex-treated hBMSCs. In addition, lncRNA FGD5-AS1 acts as a sponge for miR-296-5p. Also, miR-296-5p directly targets STAT3. More importantly, miR-296-5p and STAT3 can affect the function of lncRNA FGD5-AS1 in Dex-treated hBMSCs. Conclusion. lncRNA FGD5-AS1 promotes cell proliferation and inhibits apoptosis in steroid-induced ONFH through acting as a sponge for miR-296-5p and upregulation of STAT3.<\/jats:p>","DOI":"10.1155\/2022\/9364467","type":"journal-article","created":{"date-parts":[[2022,2,12]],"date-time":"2022-02-12T19:20:07Z","timestamp":1644693607000},"page":"1-9","source":"Crossref","is-referenced-by-count":10,"title":["lncRNA FGD5-AS1 Regulates Bone Marrow Stem Cell Proliferation and Apoptosis by Affecting miR-296-5p\/STAT3 Axis in Steroid-Induced Osteonecrosis of the Femoral Head"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8204-1962","authenticated-orcid":true,"given":"Yadi","family":"Wu","sequence":"first","affiliation":[{"name":"Laboratory, Shandong First Medical University, Shandong Academy of Medical Sciences, Tai\u2019an 271016, Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5389-0233","authenticated-orcid":true,"given":"Lun","family":"Fang","sequence":"additional","affiliation":[{"name":"Laboratory, Shandong First Medical University, Shandong Academy of Medical Sciences, Tai\u2019an 271016, Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9622-0152","authenticated-orcid":true,"given":"Yong","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The Second Affiliated Hospital of Shandong First Medical University, Tai\u2019an 271000, Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8483-6814","authenticated-orcid":true,"given":"Zhiqiu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Laboratory, Shandong First Medical University, Shandong Academy of Medical Sciences, Tai\u2019an 271016, Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0534-8690","authenticated-orcid":true,"given":"Lu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Sports Medicine, Shandong First Medical University, Shandong Academy of Medical Sciences, Tai\u2019an 271016, Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2706-2311","authenticated-orcid":true,"given":"Gang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The Second Affiliated Hospital of Shandong First Medical University, Tai\u2019an 271000, Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-018-3866-2"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2017.11.005"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-018-4013-9"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/os.12979"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/s00590-020-02622-5"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.3233\/thc-202244"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2019.8185"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1002\/mc.23305"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s13577-021-00536-w"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1097\/fjc.0000000000001036"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2021.1982230"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.11694"},{"issue":"7","key":"13","first-page":"7556","article-title":"CircRPPH1 serves as a sponge for miR-296-5p to enhance progression of breast cancer by regulating FOXP4 expression","volume":"13","author":"L. 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