{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T12:52:03Z","timestamp":1775739123146,"version":"3.50.1"},"reference-count":70,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T00:00:00Z","timestamp":1644969600000},"content-version":"vor","delay-in-days":46,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Present study established the biological potential of <jats:italic>Schweinfurthia papilionacea<\/jats:italic>, <jats:italic>Tricholepis glaberrima<\/jats:italic> and <jats:italic>Viola stocksii<\/jats:italic> extracts for their potential applications in drug formulations. Initially, FTIR was performed to ascertain functional groups and then plant extracts were prepared using five solvents depending on the polarity. Total phenolic contents were observed in the range of 36.36\u2009\u00b1\u20091.08\u2009mg GAE\/g to 95.55\u2009\u00b1\u20092.46\u2009mg GAE\/g while flavonoid contents were found in the range of 10.51\u2009\u00b1\u20090.25\u2009mg QE\/g to 22.17\u2009\u00b1\u20091.79\u2009mg QE\/g. Antioxidant activity was determined using TRP, CUPRAC, TAC and DPPH assays and was recorded highest in <jats:italic>S. papilionacea<\/jats:italic> followed by <jats:italic>T. glaberrima<\/jats:italic> extracts. TPC and TFC were found to be strongly correlated with TRP (r\u2009&gt;\u20090.50), CUPRAC (r\u2009&gt;\u20090.53) and DPPH (r\u2009=\u20090.31 and 0.72) assay while weakly correlated with TAC (r\u2009=\u20090.08 and 0.03) as determined by Pearson correlation analysis. Anticancer activity showed that <jats:italic>S. papilionacea<\/jats:italic> chloroform extracts possess highest cell viability (85.04\u2009\u00b1\u20094.24%) against HepG2 cell lines while <jats:italic>T. glaberrima<\/jats:italic> chloroform extracts exhibited highest activity (82.80\u2009\u00b1\u20092.68%) against HT144 cell lines. Afterwards, highest PXR activation was observed in <jats:italic>T. glaberrima<\/jats:italic> (3.49\u2009\u00b1\u20090.34\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL fold) at 60\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL and was correlated with increase in CYP<jats:sub>3<\/jats:sub>A<jats:sub>4<\/jats:sub> activity (15.0\u2009\u00b1\u20093.00\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL IC<jats:sub>50<\/jats:sub> value). Furthermore, antimalarial activity revealed &gt;47600 IC<jats:sub>50<\/jats:sub> value against <jats:italic>P. falciparum<\/jats:italic> D6 and <jats:italic>P. falciparum<\/jats:italic> W2 and antimicrobial assay indicated highest activity (32\u2009\u00b1\u20092.80\u2009mm) in <jats:italic>S. papilionacea<\/jats:italic> against <jats:italic>C. neoformans<\/jats:italic>. At the end, GC\u2010MS analysis of n\u2010hexane plant extracts showed 99.104% of total identified compounds in <jats:italic>T. glaberrima<\/jats:italic> and 94.31% in <jats:italic>V. stocksii<\/jats:italic>. In conclusion, present study provides insight about the different biological potentials of <jats:italic>S. papilionacea<\/jats:italic> and <jats:italic>T. glaberrima<\/jats:italic> extracts that rationalize the applications of these extracts in functional foods and herbal drugs for the management of oxidative\u2010stress related diseases, antimicrobial infections and liver and skin cancer.<\/jats:p>","DOI":"10.1155\/2022\/9366223","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T20:20:07Z","timestamp":1645042807000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["[Retracted] Antioxidant, Anticancer, and PXR\u2010Dependent CYP3A4 Attributes of Schweinfurthia papilionacea (Burm.f.) 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