{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T17:19:21Z","timestamp":1775841561535,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical Science Research Project of Hebei Province","award":["20210084"],"award-info":[{"award-number":["20210084"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"<jats:p>Objective. To investigate the related risk factors for bronchiolitis obliterans (BO) in children with mycoplasma pneumonia (MP) bronchiolitis. Method. The clinical data of 227 children with MP bronchiolitis who were admitted to the II Department of Respiratory of Children\u2019s Hospital of Hebei Province from January 2018 to June 2020 were retrospectively analyzed. According to the sequelae of BO, they were divided into 32 cases in the BO group and 195 cases in the non-BO group. The univariate analysis was performed on the clinical and laboratory parameters of the two groups, and the multifactor logistic regression was performed further to determine the independent risk factors for the occurrence of BO in MP bronchiolitis, and then, the cut-off value with the maximum diagnostic value of indicators was found through the ROC curve analysis. Results. The results of univariate and multivariate logistic regression analysis showed that the independent risk factors for the occurrence of BO in MP bronchioles were longer duration of moist rales (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mtext>OR<\/a:mtext>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>1.203<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.003<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>), higher levels of serum lactate dehydrogenase (LDH) (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mtext>OR<\/e:mtext>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>1.005<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>=<\/g:mo>\n                        <g:mn>0.036<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>), hypoxemia (<jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mtext>OR<\/i:mtext>\n                        <i:mo>=<\/i:mo>\n                        <i:mn>7.442<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>P<\/k:mi>\n                        <k:mo>=<\/k:mo>\n                        <k:mn>0.035<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula>), and pleural effusion (<jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mtext>OR<\/m:mtext>\n                        <m:mo>=<\/m:mo>\n                        <m:mn>4.437<\/m:mn>\n                     <\/m:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                        <o:mi>P<\/o:mi>\n                        <o:mo>=<\/o:mo>\n                        <o:mn>0.004<\/o:mn>\n                     <\/o:math>\n                  <\/jats:inline-formula>). The area under the ROC curve was 78.2%, 72.0%, 68.2%, and 71.0%, respectively (<jats:inline-formula>\n                     <q:math xmlns:q=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\">\n                        <q:mi>P<\/q:mi>\n                        <q:mo>&lt;<\/q:mo>\n                        <q:mn>0.001<\/q:mn>\n                     <\/q:math>\n                  <\/jats:inline-formula>). The cut-off value of duration of moist rales and levels of serum LDH are 7.5\u2009d and 330\u2009U\/L, respectively. Conclusion. Children with MP bronchiolitis with high serum LDH level (\u2265330\u2009U\/L), combined with hypoxemia, pleural effusion, and lung wet rale duration (\u22657.5\u2009d), may be more prone to BO, in which lung wet rale duration prediction value is the largest. Among them, duration of pulmonary moist rales has the highest predictive value.<\/jats:p>","DOI":"10.1155\/2022\/9371406","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T19:05:06Z","timestamp":1646161506000},"page":"1-6","source":"Crossref","is-referenced-by-count":5,"title":["Analysis of Risk Factors of Bronchiolitis Obliterans in Children with Mycoplasma pneumoniae Bronchiolitis"],"prefix":"10.1155","volume":"2022","author":[{"given":"KunLing","family":"Huang","sequence":"first","affiliation":[{"name":"Respiratory Department II, Hebei Children\u2019s Hospital, No. 133 Jianhua South Street, Shijiazhuang, 050031 Hebei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhua","family":"Liu","sequence":"additional","affiliation":[{"name":"Respiratory Department II, Hebei Children\u2019s Hospital, No. 133 Jianhua South Street, Shijiazhuang, 050031 Hebei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenshan","family":"Lv","sequence":"additional","affiliation":[{"name":"Respiratory Department II, Hebei Children\u2019s Hospital, No. 133 Jianhua South Street, Shijiazhuang, 050031 Hebei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yajuan","family":"Chu","sequence":"additional","affiliation":[{"name":"Respiratory Department II, Hebei Children\u2019s Hospital, No. 133 Jianhua South Street, Shijiazhuang, 050031 Hebei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baochi","family":"Li","sequence":"additional","affiliation":[{"name":"Respiratory Department II, Hebei Children\u2019s Hospital, No. 133 Jianhua South Street, Shijiazhuang, 050031 Hebei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Wu","sequence":"additional","affiliation":[{"name":"Respiratory Department II, Hebei Children\u2019s Hospital, No. 133 Jianhua South Street, Shijiazhuang, 050031 Hebei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1487-0229","authenticated-orcid":true,"given":"Jinfeng","family":"Shuai","sequence":"additional","affiliation":[{"name":"Respiratory Department II, Hebei Children\u2019s Hospital, No. 133 Jianhua South Street, Shijiazhuang, 050031 Hebei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1093\/occmed\/kqu091"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24221"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/resp.13498"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.913723"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-2779"},{"issue":"7","key":"6","first-page":"563","article-title":"Research progress of bronchiolitis obliterans in children","volume":"36","author":"Y. J. Tang","year":"2018","journal-title":"Journal of Clinical Pediatrics"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1086\/516124"},{"issue":"12","key":"8","first-page":"963","article-title":"Clinical characteristics and prognosis of mycoplasma pneumonia bronchiolitis in children. Chinese Journal of Practical","volume":"35","author":"Xiaohui Wen","year":"2020","journal-title":"Pediatrics"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2020.106209"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24896"},{"issue":"3","key":"11","first-page":"202","article-title":"Talking about Mycoplasma pneumoniae bronchiolitis. Chinese Journal of Practical","volume":"36","author":"S. Y. Q. Lu","year":"2021","journal-title":"Pediatrics"},{"issue":"17","key":"12","first-page":"1304","article-title":"Expert consensus on diagnosis and treatment of Mycoplasma pneumoniae pneumonia in children","volume":"30","author":"Respiratory Group of Pediatrics Branch of Chinese Medical Association","year":"2015","journal-title":"Chinese Journal of Practical Pediatrics and Clinical Medicine"},{"issue":"10","key":"13","first-page":"743","article-title":"Diagnosis and treatment of bronchiolitis obliterans in children","volume":"50","author":"Respiratory Group of Pediatrics Branch of Chinese Medical Association","year":"2012","journal-title":"Chinese Journal of Pediatrics"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/s004280100473"},{"issue":"1","key":"15","first-page":"34","article-title":"Open lung biopsy in Mycoplasma pneumoniae pneumonia","volume":"110","author":"S. Rollins","year":"1986","journal-title":"Archives of Pathology & Laboratory Medicine"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1093\/trstmh\/trv042"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25703"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20472"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-016-3237-7"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1097\/RCT.0b013e3181635e50"},{"issue":"4","key":"21","first-page":"269","article-title":"Clinical and prognostic analysis of 46 children with severe mycoplasma pneumoniae pneumonia complicated with pleural effusion","volume":"38","author":"Chongjie Wang","year":"2020","journal-title":"Journal of Clinical Pediatrics"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24892"},{"issue":"2","key":"23","first-page":"112","article-title":"Value of lactate dehydrogenase in predicting refractory Mycoplasma pneumoniae pneumonia in children: an evaluation based on decision curve analysis and dose-response analysis","volume":"22","author":"X. X. Zheng","year":"2020","journal-title":"Chinese Journal of Contemporary Pediatrics"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2017.12.008"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-08861-7"}],"updated-by":[{"DOI":"10.1155\/2023\/9838639","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T00:00:00Z","timestamp":1687910400000},"record-id":"47083"},{"DOI":"10.1155\/2023\/9838639","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T00:00:00Z","timestamp":1687910400000}}],"container-title":["Computational and Mathematical Methods in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2022\/9371406.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2022\/9371406.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2022\/9371406.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T19:05:17Z","timestamp":1646161517000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cmmm\/2022\/9371406\/"}},"subtitle":[],"editor":[{"given":"Min","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,3,1]]},"references-count":25,"alternative-id":["9371406","9371406"],"URL":"https:\/\/doi.org\/10.1155\/2022\/9371406","relation":{"retraction":[{"id-type":"doi","id":"10.1155\/2023\/9838639","asserted-by":"object"}]},"ISSN":["1748-6718","1748-670X"],"issn-type":[{"value":"1748-6718","type":"electronic"},{"value":"1748-670X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3,1]]}}}