{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:55:57Z","timestamp":1767167757419,"version":"build-2238731810"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T00:00:00Z","timestamp":1664236800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007194","name":"Wenzhou Science and Technology Bureau","doi-asserted-by":"crossref","award":["Y20210812"],"award-info":[{"award-number":["Y20210812"]}],"id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007194","name":"Wenzhou Science and Technology Bureau","doi-asserted-by":"crossref","award":["HYD2020JQ0005"],"award-info":[{"award-number":["HYD2020JQ0005"]}],"id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007194","name":"Wenzhou Science and Technology Bureau","doi-asserted-by":"crossref","award":["No81500288"],"award-info":[{"award-number":["No81500288"]}],"id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010722","name":"Harbin Medical University","doi-asserted-by":"publisher","award":["Y20210812"],"award-info":[{"award-number":["Y20210812"]}],"id":[{"id":"10.13039\/100010722","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010722","name":"Harbin Medical University","doi-asserted-by":"publisher","award":["HYD2020JQ0005"],"award-info":[{"award-number":["HYD2020JQ0005"]}],"id":[{"id":"10.13039\/100010722","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010722","name":"Harbin Medical University","doi-asserted-by":"publisher","award":["No81500288"],"award-info":[{"award-number":["No81500288"]}],"id":[{"id":"10.13039\/100010722","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Y20210812"],"award-info":[{"award-number":["Y20210812"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["HYD2020JQ0005"],"award-info":[{"award-number":["HYD2020JQ0005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No81500288"],"award-info":[{"award-number":["No81500288"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2022,9,27]]},"abstract":"<jats:p>\n                    Background. This study is aimed at investigating whether relaxin-3 exhibits protective effects against cardiomyopathy in diabetic rats by suppressing ERS. Methods. Eighty male SD rats were randomly divided into two groups: controls (\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>n<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>20<\/a:mn>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    ) and diabetes (\n                    <jats:inline-formula>\n                      <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>n<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>60<\/c:mn>\n                      <\/c:math>\n                    <\/jats:inline-formula>\n                    ). The streptozotocin-treated rats were randomly divided into three groups: diabetic group (DM), low-dose relaxin-3 group (0.2\u2009\u03bcg\/kg\/d), and high-dose relaxin-3 group (2\u2009\u03bcg\/kg\/d). The myocardial tissues and collagen fiber were observed by hematoxylin and eosin (H&amp;E) and Masson staining. Serum brain natriuretic peptide (BNP), troponin (TNI), myoglobin, interleukin (IL-17), interleukin (IL)-1\u03b1, and tumor necrosis factor (TNF)-\u03b1 were determined by ELISA. The protein expression of glucose regulatory protein 78 (GRP78) and C\/EBP homologous protein (CHOP) in the heart tissue of each group was detected by Western blot analysis. Results. (1) HE and Masson staining indicated that relaxin-3 could attenuate myocardial lesions and myocardial collagen volume fraction. (2) BNP, TnI, and myoglobin in the DM group at four and eight weeks were significantly higher than in the controls (\n                    <jats:inline-formula>\n                      <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.01<\/e:mn>\n                      <\/e:math>\n                    <\/jats:inline-formula>\n                    ). The relaxin-3-treated groups showed significantly reduced serum BNP, TnI, and myoglobin levels compared with the DM group (\n                    <jats:inline-formula>\n                      <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>&lt;<\/g:mo>\n                        <g:mn>0.05<\/g:mn>\n                      <\/g:math>\n                    <\/jats:inline-formula>\n                    ). (3) IL-17, IL-1\u03b1, and TNF-\u03b1 levels in the DM rats at 4 weeks were higher than in the controls (\n                    <jats:inline-formula>\n                      <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>P<\/i:mi>\n                        <i:mo>&lt;<\/i:mo>\n                        <i:mn>0.05<\/i:mn>\n                      <\/i:math>\n                    <\/jats:inline-formula>\n                    ). Low or high dose of relaxin-3-treated groups showed reduced serum IL-17 and TNF-\u03b1 levels compared with the DM group at four and eight weeks (\n                    <jats:inline-formula>\n                      <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>P<\/k:mi>\n                        <k:mo>&lt;<\/k:mo>\n                        <k:mn>0.05<\/k:mn>\n                      <\/k:math>\n                    <\/jats:inline-formula>\n                    ). (4) CHOP and GRP78 protein expression was increased in the DM group at four and eight weeks compared with the controls (\n                    <jats:inline-formula>\n                      <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mi>P<\/m:mi>\n                        <m:mo>&lt;<\/m:mo>\n                        <m:mn>0.01<\/m:mn>\n                      <\/m:math>\n                    <\/jats:inline-formula>\n                    ), and small and large doses of relaxin-3 significantly reduced GRP78 and CHOP protein expression. Conclusions. Exogenous relaxin-3 ameliorates diabetic cardiomyopathy by inhibiting ERS in diabetic rats.\n                  <\/jats:p>","DOI":"10.1155\/2022\/9380283","type":"journal-article","created":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T19:20:19Z","timestamp":1664306419000},"page":"1-7","source":"Crossref","is-referenced-by-count":1,"title":["Relaxin-3 Ameliorates Diabetic Cardiomyopathy by Inhibiting Endoplasmic Reticulum Stress"],"prefix":"10.1155","volume":"2022","author":[{"given":"Li-ya","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University, Wenzhou 325000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wu-jie","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University, Wenzhou 325000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2701-4221","authenticated-orcid":true,"given":"Jia-lin","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University, Wenzhou 325000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-12-158"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1209038"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2014.05.006"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00501"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2014.11.004"},{"key":"6","first-page":"H1358","article-title":"Quantification of calcium paradox in neonatal rat hearts","volume":"253, 6, Part 2","author":"J. 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