{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T22:31:35Z","timestamp":1740177095490,"version":"3.37.3"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T00:00:00Z","timestamp":1664150400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019339","name":"Tsinghua Initiative Scientific Research Program","doi-asserted-by":"publisher","award":["20182000306","2020THFS0118"],"award-info":[{"award-number":["20182000306","2020THFS0118"]}],"id":[{"id":"10.13039\/501100019339","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Tsinghua Precision Medicine Foundation","award":["20182000306","2020THFS0118"],"award-info":[{"award-number":["20182000306","2020THFS0118"]}]},{"name":"Tsinghua-Foshan Innovation Special Fund","award":["20182000306","2020THFS0118"],"award-info":[{"award-number":["20182000306","2020THFS0118"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2022,9,26]]},"abstract":"<jats:p>Cirrhosis-induced clinically significant portal hypertension (CSPH) is a fatal disease. Early detection of CSPH is vitally important to reduce the patients\u2019 mortality rate. In this study, combined with three-dimensional image construction technology and computational fluid dynamics (CFD), an image-based flow resistance analysis was proposed. The flow resistance analysis was performed for nine cirrhosis patients with CSPH and ten participants without liver diseases, respectively. The results showed that the flow resistance coefficient of the portal vein system in CSPH patients was significantly lower than that in the control group (0.97\u2009\u00b1\u20090.11\u2009Pa\/(mL\/s) for CSPH patients; 1.80\u2009\u00b1\u20090.40\u2009Pa\/(mL\/s) for the control group; <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.028<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). In contrast, although main portal vein dilation was found in CSPH patients, the cross-sectional area enlargement was not statistically significant (186.01\u2009\u00b1\u200957.48\u2009mm2 for CSPH patients; 166.26\u2009\u00b1\u200933.74\u2009mm2 for the control group; <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.39<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). The research outcomes indicated that the flow resistance analysis was more sensitive than the commonly used vessel size measurement in the detection of CSPH. In summary, we suggest using flow resistance analysis as a supplementary noninvasive method to detect cirrhosis patients with CSPH.<\/jats:p>","DOI":"10.1155\/2022\/9396371","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T23:50:07Z","timestamp":1664236207000},"page":"1-7","source":"Crossref","is-referenced-by-count":1,"title":["Flow Resistance Analysis of Clinically Significant Portal Hypertension in Patients with Liver Cirrhosis"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6892-6729","authenticated-orcid":true,"given":"Yizhe","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Radiology, Beijing Tsinghua Changgung Hospital, School of Medicine, Tsinghua University, Beijing 102218, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6857-062X","authenticated-orcid":true,"given":"Luxiang","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering, State Key Laboratory of Tribology, Tsinghua University, Beijing 100084, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8547-6670","authenticated-orcid":true,"given":"Zhuozhao","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Tsinghua Changgung Hospital, School of Medicine, Tsinghua University, Beijing 102218, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2560-3927","authenticated-orcid":true,"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Medicine, Tsinghua University, Beijing 100084, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s13239-014-0195-5"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0096(200101)29:1<7::aid-jcu2>3.0.co;2-v"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20871"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(14)60121-5"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2018180425"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2021.01.005"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.medengphy.2012.07.005"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.powtec.2018.07.091"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.powtec.2019.05.076"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.a2274"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1056\/nejm200006083422302"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.06.066"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1142\/s0219519414400065"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.3233\/bme-151310"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.02.008"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2006.11.010"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20506"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.05.022"},{"volume-title":"Handbook of Hydraulics for the Solution of Hydraulic Engineering Problems","year":"1976","author":"F. 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