{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T16:34:02Z","timestamp":1793291642481,"version":"4.5.0"},"reference-count":45,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T00:00:00Z","timestamp":1658275200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Haikou Maternal and Child Health Hospital"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2022,7,20]]},"abstract":"<jats:p>Background. The relationship between vitamin D and atopic dermatitis (AD) is controversial. This meta-analysis is aimed at exploring vitamin D level and its deficiency in pediatric AD and at evaluating the efficacy of vitamin D supplementation. Methods. PubMed, Medline, Embase, Ovid, Cochrane Library, ISI Web of Science, and ClinicalTrials were searched. Binary variables and continuous variables were measured by odds ratio (OR) and mean difference (MD) with 95% confidence intervals, respectively. The modified Jadad scale, Newcastle-Ottawa Scale (NOS), and Cochrane\u2019s bias risk tools were used to evaluate study quality and the risk of bias of eligible studies, respectively. Results. A total of 22 literature were included in the analysis. Serum 25 (OH) D level in pediatric AD patients was significantly lower than that of the control group with a combined MD value of -8.18 (95% CI: -13.15, -3.22). Patients with AD were more prone to develop vitamin D deficiency with a combined OR value of 2.17 (95% CI: 1.15, 4.11). According to the score of SCORAD, the level of serum 25 (OH) D level in patients with severe AD was significantly lower than that in patients with mild AD (combined <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mtext>MD<\/a:mtext>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>9.23<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>, 95% CI: 6.92, 11.55). Both self-control studies and randomized controlled trials showed improved SCORAD score and EASI score after vitamin D supplementation. Conclusion. This meta-analysis showed lower serum 25 (OH) D level and increased risk of vitamin D deficiency in pediatric AD patients as compared with healthy controls. The serum 25 (OH) D level in severe AD patients was significantly lower than that in the mild AD patients. The SCORAD and EASI score improved after vitamin D supplementation, suggesting its beneficial effect to AD patients. At the same time, more homogeneous studies are needed to reduce confounding factors and further evaluate the impact of vitamin D treatment on the outcome of AD patients.<\/jats:p>","DOI":"10.1155\/2022\/9407888","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T01:35:09Z","timestamp":1658367309000},"page":"1-9","source":"Crossref","is-referenced-by-count":17,"title":["Serum Vitamin D Level and Efficacy of Vitamin D Supplementation in Children with Atopic Dermatitis: A Systematic Review and Meta-analysis"],"prefix":"10.1155","volume":"2022","author":[{"given":"Hongbo","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Emergency, Haikou Maternal and Child Health Hospital, Haikou, 570203 Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanting","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Sanya Traditional Chinese Medicine Hospital, Sanya, 572000 Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The First Affiliated Hospital of Hainan Medical University, Haikou, 570102 Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9865-8676","authenticated-orcid":true,"given":"Dan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The First Affiliated Hospital of Hainan Medical University, Haikou, 570102 Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-64804-0_3"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2019.40.4202"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000000560"},{"issue":"5","key":"4","first-page":"293","article-title":"Atopic dermatitis in children","volume":"45","author":"S. 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