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To study the role of bacterial biofilm (BBF) in the formation of chronic osteomyelitis and its prevention and treatment. Methods. In this paper, a large amount of relevant literature was searched for analysis and summary, and the key words \u201cchronic osteomyelitis,\u201d \u201cbacterial biofilm,\u201d \u201cinfection,\u201d and \u201cdebridement\u201d were searched in databases, mainly CNKI, Wanfang, and Wipu. The search was conducted until December 2020. The role of bacterial biofilm formation in chronic osteomyelitis and its prevention were analyzed. Results. Chronic osteomyelitis is formed mainly due to poor blood supply and drug-resistant bacteria, of which cellular biofilm is the most important cause. BBF forms on the surface of necrotic soft tissue and bone tissue, which has a protective effect on bacteria and greatly enhances their resistance to antibiotics, leading to difficulties in complete bacterial clearance and recurrent infections in osteomyelitis. Conclusion. Through an in-depth study of the molecular biology and signal transduction of osteomyelitis biofilm, antibiotic biofilm treatment strategies and surgical debridement remain the focus of clinical translation of chronic osteomyelitis.<\/jats:p>","DOI":"10.1155\/2022\/9433847","type":"journal-article","created":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T02:50:19Z","timestamp":1662691819000},"page":"1-8","source":"Crossref","is-referenced-by-count":8,"title":["Correlation Analysis between Chronic Osteomyelitis and Bacterial Biofilm"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3932-6636","authenticated-orcid":true,"given":"Kai","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Tongde Hospital of Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9267-2661","authenticated-orcid":true,"given":"Bingyuan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Tongde Hospital of Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2356-8294","authenticated-orcid":true,"given":"Yiyang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Tongde Hospital of Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1779-8990","authenticated-orcid":true,"given":"Haiyong","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Tongde Hospital of Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9491-9768","authenticated-orcid":true,"given":"Qiaofeng","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Tongde Hospital of Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2005.07.002"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(01)02012-1"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.31.5.1081"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.26689\/par.v2i6.726"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-019-0061-z"},{"issue":"1","key":"6","first-page":"1","article-title":"Staphylococcus aureus osteomyelitis: characterization of bacterial antigens and utilization as vaccine candidates and imaging targets","volume":"17","author":"R. 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