{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T13:32:40Z","timestamp":1747229560164,"version":"3.37.3"},"reference-count":57,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC_U12266B","15293","17868"],"award-info":[{"award-number":["MC_U12266B","15293","17868"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012041","name":"Versus Arthritis","doi-asserted-by":"publisher","award":["MC_U12266B","15293","17868"],"award-info":[{"award-number":["MC_U12266B","15293","17868"]}],"id":[{"id":"10.13039\/501100012041","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2022,9,16]]},"abstract":"<jats:p>Salmonella enteritica (S. enteritica) induce and require unfolded protein response (UPR) pathways for intracellular replication. Salmonella infections can lead to reactive arthritis (ReA), which can exhibit associations with Human Leucocyte Antigen (HLA)-B<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:msup>\n                           <a:mrow\/>\n                           <a:mrow>\n                              <a:mo>\u2217<\/a:mo>\n                           <\/a:mrow>\n                        <\/a:msup>\n                     <\/a:math>\n                  <\/jats:inline-formula>27\u2009:\u200905. S. enteritica normally reside in a juxtanuclear position to the Golgi apparatus, representing the formation and residence within the Salmonella-containing vacuole (SCV). Changes in cellular localization of infecting Salmonella can alter their ability to replicate. We therefore used isogenic epithelial cell lines expressing physiological levels of HLA-B<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:msup>\n                           <c:mrow\/>\n                           <c:mrow>\n                              <c:mo>\u2217<\/c:mo>\n                           <\/c:mrow>\n                        <\/c:msup>\n                     <\/c:math>\n                  <\/jats:inline-formula>27\u2009:\u200905 heavy chain (HC) and a control HLA-B allele, HLA-B<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:msup>\n                           <e:mrow\/>\n                           <e:mrow>\n                              <e:mo>\u2217<\/e:mo>\n                           <\/e:mrow>\n                        <\/e:msup>\n                     <\/e:math>\n                  <\/jats:inline-formula>35\u2009:\u200901.HC to determine any changes in Salmonella localization within epithelial cells. Expression of HLA-B<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:msup>\n                           <g:mrow\/>\n                           <g:mrow>\n                              <g:mo>\u2217<\/g:mo>\n                           <\/g:mrow>\n                        <\/g:msup>\n                     <\/g:math>\n                  <\/jats:inline-formula>27\u2009:\u200905 but not HLA-B<jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:msup>\n                           <i:mrow\/>\n                           <i:mrow>\n                              <i:mo>\u2217<\/i:mo>\n                           <\/i:mrow>\n                        <\/i:msup>\n                     <\/i:math>\n                  <\/jats:inline-formula>35\u2009:\u200901 was associated with a quantifiable change in S. enteritica cellular distribution away from the Golgi apparatus. Furthermore, the Salmonella requirements for UPR induction and the consequences of the concomitant endoplasmic reticulum (ER) membrane expansion were determined. Using confocal imaging, S. enteritica bacteria exhibited a significant and quantifiable codistribution with endo-reticular membrane as determined by ER tracker staining. Isogenic S. enterica Typhimurium mutant strains, which can infect but exhibit impaired intracellular growth, demonstrated that the activation of the UPR was dependent on an integral intracellular niche. Therefore, these data identify cellular changes accompanying Salmonella induction of the UPR and in the presence of HLA-B27.<\/jats:p>","DOI":"10.1155\/2022\/9493019","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T23:05:12Z","timestamp":1663369512000},"page":"1-9","source":"Crossref","is-referenced-by-count":3,"title":["Salmonella Exhibit Altered Cellular Localization in the Presence of HLA-B27 and Codistribute with Endo-Reticular Membrane"],"prefix":"10.1155","volume":"2022","author":[{"given":"Janos","family":"Kriston-Vizi","sequence":"first","affiliation":[{"name":"Laboratory for Molecular Cell Biology, Medical Research Council, University College London, Gower Street, London WC1E 6BT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izabela","family":"Lenart","sequence":"additional","affiliation":[{"name":"SciencePharma, Che\u0142mska Street 30\/34, 00-725 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Iwawaki","sequence":"additional","affiliation":[{"name":"Division of Cell Medicine, Department of Life Science, Medical Research Institute, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Kahoku, Ishikawa 920-0293, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith","family":"Gould","sequence":"additional","affiliation":[{"name":"Wright-Fleming Institute, Imperial College London, London, W2, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1596-9407","authenticated-orcid":true,"given":"Darren","family":"Nesbeth","sequence":"additional","affiliation":[{"name":"The Advanced Centre for Biochemical Engineering, University College London, Gower Street, London WC1E 7JE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon J.","family":"Powis","sequence":"additional","affiliation":[{"name":"School of Medicine, University of St. Andrews, Fife, KY16 9TF, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6536-7781","authenticated-orcid":true,"given":"Antony N.","family":"Antoniou","sequence":"additional","affiliation":[{"name":"The Advanced Centre for Biochemical Engineering, University College London, Gower Street, London WC1E 7JE, UK"},{"name":"Department of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne NE1 8ST, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3693"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.4.2438"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-4310(00)01699-3"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.2174\/1566524043479293"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2009.00865.x"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1002\/art.24763"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1002\/art.38809"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-213532"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200425724"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e328303204b"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1002\/kjm2.12184"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.3329\/jhpn.v31i3.16515"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200007)43:7<1527::AID-ANR17>3.0.CO;2-G"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.083451"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)90675-S"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.3109\/03009742.2012.739201"},{"issue":"8","key":"17","first-page":"1599","article-title":"Symptomatic acute reactive arthritis after an outbreak of Salmonella","volume":"35","author":"S. 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