{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T13:45:58Z","timestamp":1767015958061,"version":"3.41.2"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T00:00:00Z","timestamp":1661385600000},"content-version":"vor","delay-in-days":236,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p><jats:italic>Purpose.<\/jats:italic> Effectively controlling the accumulation of adipose tissue can be a therapeutic strategy for treating obesity, which is a global problem. The present study was designed for comparative assessment of <jats:italic>in vitro<\/jats:italic> antiobesity activities of the <jats:italic>Psoralea corylifolia<\/jats:italic>\u2010dichloromethane seed extract (DCME) and the isolated phytochemicals, bakuchiol, isopsoralen, and psoralen, through antiadipogenesis and pancreatic lipase (PL) inhibition assays. <jats:italic>Material and Methods. In vitro<\/jats:italic> pancreatic lipase activity was determined spectrophotometrically by measuring the hydrolysis of <jats:italic>p<\/jats:italic>\u2010nitrophenyl butyrate (<jats:italic>p<\/jats:italic>\u2010NPB) to <jats:italic>p<\/jats:italic>\u2010nitrophenol at 405\u2009nm, and adipogenesis was assayed in 3\u2009T3\u2010L1 adipocytes (by using Oil Red O staining) using <jats:italic>P. corylifolia<\/jats:italic>\u2010dichloromethane seed extract (DCME) and individual compounds, isolated from the extract. <jats:italic>Result.<\/jats:italic> Antilipase as well as antiadipogenesis activity was displayed by both the DCME and the compounds. Maximum antilipase property was recorded in DCME (26.02 \u00b1 .041%) at 100\u2009<jats:italic>\u03bc<\/jats:italic>g\/ml, while, among the isolated compounds, bakuchiol exhibited a higher activity (24.2 \u00b1 0.037%) at 100\u2009<jats:italic>\u03bc<\/jats:italic>g\/ml concentration, compared to other isolates. DCME was found to exhibit antiadipogenesis property, 75 \u00b1 0.003% lipid accumulation, compared to the control at 100\u2009<jats:italic>\u03bc<\/jats:italic>g\/ml dose. Bakuchiol, isopsoralen, and psoralen inhibited the lipid accumulation in 3T3\u2010L1 preadipocytes, 78.06 \u00b1 0.002%, 80.91 \u00b1 0.004%, and 80.91 \u00b1 0.001%, respectively, lipid accumulation in comparison to control at 25\u2009<jats:italic>\u03bc<\/jats:italic>M dose. <jats:italic>Conclusion.<\/jats:italic> The present study highlights the antiobesity potential of <jats:italic>P. corylifolia<\/jats:italic> and its active constituents. Thus, it can be concluded that <jats:italic>P. corylifolia<\/jats:italic> has the potential to treat obesity and related diseases; however, further research on dose standardization and clinical trials are required.<\/jats:p>","DOI":"10.1155\/2022\/9504787","type":"journal-article","created":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T01:50:14Z","timestamp":1661478614000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Antiobesity Potential of Bioactive Constituents from Dichloromethane Extract of <i>Psoralea corylifolia<\/i> L. 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