{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T04:29:12Z","timestamp":1783225752239,"version":"3.54.6"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T00:00:00Z","timestamp":1672185600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Medicine"],"published-print":{"date-parts":[[2022,12,28]]},"abstract":"<jats:p>Transient pancytopenia due to reactive bone marrow suppression often occurs in hemophagocytic lymphohistiocytosis (HLH), a syndrome resulting from excessive immune activation following a severe infection. We reported two cases with pancytopenia and disseminated histoplasmosis accompanied by HLH, initially suspected to be blood malignancies. Our first case documented the relevance between the improvement of pancytopenia and the clearance of Histoplasma capsulatum in serial bone marrow aspirations. The second case showed immense Histoplasma engulfment by the macrophage in relation to a severe clinical condition, followed by improvement of clinical symptoms in accordance with the recovery of pancytopenia. These two cases highlighted the importance of comprehensive and critical analysis for cases with concurrent pancytopenia and severe infection, since it may be that the pancytopenia underlies the severe infection or vice versa.<\/jats:p>","DOI":"10.1155\/2022\/9521128","type":"journal-article","created":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T20:20:13Z","timestamp":1672258813000},"page":"1-6","source":"Crossref","is-referenced-by-count":3,"title":["Two Cases of Hemophagocytic Lymphohistiocytosis Associated with Disseminated Histoplasmosis Presented with Transient Pancytopenia"],"prefix":"10.1155","volume":"2022","author":[{"given":"Novi","family":"Apriany","sequence":"first","affiliation":[{"name":"Study Program of Subspecialty, Department of Internal Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada\/Dr. Sardjito General Hospital, Yogyakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usi","family":"Sukorini","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada\/Dr. Sardjito General Hospital, Yogyakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tri","family":"Ratnaningsih","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada\/Dr. Sardjito General Hospital, Yogyakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rizka Humardewayanti","family":"Asdie","sequence":"additional","affiliation":[{"name":"Division of Tropical Medicine and Infectious Disease, Department of Internal Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada\/Dr. Sardjito General Hospital, Yogyakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanri Wijayanti","family":"Subronto","sequence":"additional","affiliation":[{"name":"Division of Tropical Medicine and Infectious Disease, Department of Internal Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada\/Dr. Sardjito General Hospital, Yogyakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna Hilda","family":"Hutajulu","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada\/Dr. Sardjito General Hospital, Yogyakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibnu","family":"Purwanto","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada\/Dr. Sardjito General Hospital, Yogyakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5360-6693","authenticated-orcid":true,"given":"Mardiah Suci","family":"Hardianti","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada\/Dr. Sardjito General Hospital, Yogyakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.00027-06"},{"issue":"12","key":"2","first-page":"2247","article-title":"Overview of histoplasmosis","volume":"66","author":"R. 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