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In this study, we examined the effects of dihydrotestosterone (DHT) on characteristic changes in rat anterior pituitary gland samples. DHT was administered to ovary-intact 6-week postnatal female rats for 7\u2009days, after which the anterior pituitary glands were examined and compared with those in control rats. Estrous cyclicity was not drastically disrupted by DHT treatment. Common gonadotropin \u03b1 subunit (Cga), luteinizing hormone \u03b2 subunit (Lhb), and follicle-stimulating hormone (FSH) \u03b2 subunit (Fshb) gene expression levels were not modulated by DHT treatment, while prolactin (Prl) gene expression was significantly repressed by DHT. Gonadotropin-releasing hormone (GnRH) receptor (Gnrh-r) gene expression was significantly inhibited by DHT, whereas pituitary adenylate cyclase-activating polypeptide (PACAP) receptor (Pca1-r) gene expression was increased by DHT. Gene expression levels of the receptors encoded by thyrotropin-releasing hormone (Trh-r) and kisspeptin (Kiss1-r) genes were unchanged. Expression of inhibin \u03b1 subunit (Inha) and activin \u03b2A subunits (Actba) within the pituitary was inhibited by DHT treatment, while activin B subunit (Actbb) and follistatin (Fst) gene expression was unchanged by DHT. In mouse pituitary gonadotroph L\u03b2T2 cells, DHT did not modulate the gene expression of Gnrh-r, but it inhibited the expression of Inha and Actba subunits within the L\u03b2T2 cells. In rat prolactin-producing GH3 cells, DHT did not modulate prolactin gene expression, but it increased Pac1-r gene expression. The present observations suggest that DHT directly or indirectly affects the anterior pituitary gland and induces characteristic changes in hormone-producing cells.<\/jats:p>","DOI":"10.1155\/2022\/9525227","type":"journal-article","created":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T20:35:12Z","timestamp":1666384512000},"page":"1-11","source":"Crossref","is-referenced-by-count":5,"title":["Impact of One-Week Administration of Dihydrotestosterone in Rat Anterior Pituitary Gland"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7011-8109","authenticated-orcid":true,"given":"Haruhiko","family":"Kanasaki","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 693-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuvshintugs","family":"Tumurbaatar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 693-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhouma","family":"Cairang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 693-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolzaya","family":"Tumurgan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 693-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aki","family":"Oride","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 693-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroe","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 693-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Kyo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 693-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2006.02.004"},{"issue":"3","key":"2","first-page":"168","article-title":"Hirsutism in women","volume":"100","author":"E. 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