{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T17:40:10Z","timestamp":1756057210967,"version":"3.44.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:00:00Z","timestamp":1661299200000},"content-version":"vor","delay-in-days":235,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Collectivit\u00e9 de Corse"},{"name":"Invasives Terrestres et Marines"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Analytical Methods in Chemistry"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>An experimental procedure using <jats:sup>1<\/jats:sup>H NMR was developed and validated to quantify 5\u2010hydroxymethyl\u20102(5H)\u2010furanone, a valuable chemical synthon ((S)\u2010enantiomer), in a dichloromethane extract of <jats:italic>Helleborus lividus<\/jats:italic> subsp. <jats:italic>corsicus<\/jats:italic> leaves. This method, using vanillin as the internal standard, exhibited a perfect linearity of measurements (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20091) associated with very good accuracy (relative errors comprised between \u22121.62% and 4.25%) and precision (reproducibility 30.51\u2009mg\u2009\u00b1\u20090.4%). The limit of detection and the limit of quantitation have been measured at 0.14\u2009mg and 0.59\u2009mg, respectively. The experiment time is very short since a single analysis is at the minute level. 5\u2010Hydroxymethyl\u20102(5H)\u2010furanone accounted for nearly 85% in the dichloromethane extract of <jats:italic>H. lividus<\/jats:italic> subsp. <jats:italic>corsicus<\/jats:italic> leaves (1.7% of the mass of fresh leaves). This plant represents an important and natural source of (S)\u20105\u2010hydroxymethyl\u20102(5H)\u2010furanone (main enantiomer; determined using a GC chiral analysis).<\/jats:p>","DOI":"10.1155\/2022\/9580338","type":"journal-article","created":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T02:05:28Z","timestamp":1661393128000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Validated <sup>1<\/sup>H NMR Method for the Quantitation of 5\u2010Hydroxymethyl\u20102(5H)\u2010Furanone, a Valuable Chemical Intermediate, In a Dichloromethane Extract of <i>Helleborus lividus<\/i> subsp: C<i>orsicus<\/i> Leaves from Corsica"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1608-7529","authenticated-orcid":false,"given":"Thomas","family":"Maroselli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1536-5662","authenticated-orcid":false,"given":"Mathieu","family":"Paoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0609-4901","authenticated-orcid":false,"given":"Ange","family":"Bighelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,24]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200500513"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1039\/C39790000652"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0040-4020(01)82416-9"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.oprd.9b00468"},{"key":"e_1_2_7_5_2","first-page":"56","article-title":"Bioactivity guided phytochemical study of Clematis hirsuta growing in Saudia Arabia","volume":"14","author":"Abdel-Kader S. 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