{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T04:14:24Z","timestamp":1789100064527,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T00:00:00Z","timestamp":1669161600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shenzhen Key Medical Discipline Construction","award":["SZXK062"],"award-info":[{"award-number":["SZXK062"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2022,11,23]]},"abstract":"<jats:p>Objective. Circulating miRNAs are acclaimed biomarkers to predict the occurrence and progression of type 2 diabetes mellitus (T2DM). This study is aimed at analyzing the correlation of circulating miR-210 level and obesity-associated T2DM and then investigating the underlying mechanism of circulating miR-210 in T2DM. Methods. Totally, 137 serum samples from patients with T2DM were collected; meanwhile, the demographic, general, and clinical hematological characteristics, disease history, and dietary patterns were recorded. The miR-210 level in exosomes from serum was detected by qRT-PCR. Then, the correlations of BMI or miR-210 level with patients\u2019 clinical characteristics were analyzed. Furthermore, the miR-210 level was detected in T2DM related various cells under high glucose condition. Meanwhile, the expression of carbohydrate responsive element binding protein (ChREBP) and hypoxia-inducible factor 1\u03b1 (HIF-1\u03b1) was measured by western blotting. Results. The miR-210 level in exosomes from serum was obviously elevated in the <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mtext>BMI<\/a:mtext>\n                        <a:mo>&gt;<\/a:mo>\n                        <a:mn>24<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula> group compared with the <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mtext>BMI<\/c:mtext>\n                        <c:mo>\u2264<\/c:mo>\n                        <c:mn>24<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula> group. Higher BMI was correlated with abnormal lipid metabolism and impaired liver function as well as higher miR-210 level. Notably, higher miR-210 level was also correlated with abnormal lipid metabolism, disease history, and dietary patterns. In addition, compared with normal cells, high glucose increased the miR-210 level in exosomes from cell culture supernatants as well as cells in HUVEC, VSMC, RAW 264.7, 3\u2009T3-L1, SMC, and Beta-TC-6 cells, while it reduced the expression of ChREBP and HIF-1\u03b1. Conclusions. Circulating miR-210 level was closely correlated with obesity-associated T2DM. Furthermore, higher miR-210 level might be implicated in the occurrence and development of T2DM and its complications.<\/jats:p>","DOI":"10.1155\/2022\/9611509","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T21:03:42Z","timestamp":1669323822000},"page":"1-10","source":"Crossref","is-referenced-by-count":15,"title":["Elevation of Circulating miR-210 Participates in the Occurrence and Development of Type 2 Diabetes Mellitus and Its Complications"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2647-1631","authenticated-orcid":true,"given":"Xi","family":"Chen","sequence":"first","affiliation":[{"name":"Department of General Practice, Shenzhen Luohu People\u2019s Hospital, The 3rd Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3715-2281","authenticated-orcid":true,"given":"Feng","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Health Care, The Shunde Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6090-1941","authenticated-orcid":true,"given":"Zhilian","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shenzhen Luohu People\u2019s Hospital, The 3rd Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2835-6768","authenticated-orcid":true,"given":"Guoqing","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of General Practice, Shenzhen Luohu People\u2019s Hospital, The 3rd Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7964-8074","authenticated-orcid":true,"given":"Ping","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of General Practice, Shenzhen Luohu People\u2019s Hospital, The 3rd Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.151"},{"issue":"1","key":"2","doi-asserted-by":"crossref","DOI":"10.7257\/1053-816X.2016.36.1.27","article-title":"Diabetes mellitus review","volume":"36","author":"M. 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