{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:45:55Z","timestamp":1780638355247,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T00:00:00Z","timestamp":1647907200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2022,3,22]]},"abstract":"<jats:p>Objective. To investigate the differences between inhaled nitric oxide (iNO) treatment and conventional therapy in the treatment of postoperative hypoxemia in obese patients with acute type A aortic dissection (ATAAD). Methods. ATAAD patients diagnosed and treated with emergency surgery in our hospital from June 2017 to December 2019 were retrospectively analyzed. Patients with postoperative hypoxemia were divided into the iNO group and control group. Propensity score matching was used to analyze clinical characteristics and results of the two groups. Results. A total of 218 ATAAD patients with <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mtext>BMI<\/a:mtext>\n                        <a:mo>\u2265<\/a:mo>\n                        <a:mn>25<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula> were treated with surgery. Among them, 115 patients developed refractory hypoxemia (64 in the control group and 51 in the iNO group). Patients in the iNO group had significantly shorter invasive mechanical ventilation time, intensive care unit (ICU) stay, and hospital stay. After 6\u2009h of iNO treatment, the PaO2\/FiO2 ratio in the iNO group increased significantly, and this ratio was higher than that in the control group at 6, 12, 24, 48, and 72\u2009h after treatment. Conclusion. Low-dose iNO could improve oxygenation and shorten mechanical ventilation and ICU stay in patients with hypoxemia after ATAAD surgery, but without significant side effects or increase in postoperative mortality or morbidity. These findings provide a basis for a randomized multicenter controlled trial to assess the efficacy of iNO in the treatment of hypoxemia after ATAAD surgery.<\/jats:p>","DOI":"10.1155\/2022\/9612548","type":"journal-article","created":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T17:58:51Z","timestamp":1647971931000},"page":"1-6","source":"Crossref","is-referenced-by-count":9,"title":["Nitric Oxide Inhalation Therapy Attenuates Postoperative Hypoxemia in Obese Patients with Acute Type A Aortic Dissection"],"prefix":"10.1155","volume":"2022","author":[{"given":"Ping","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingsheng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8812-6377","authenticated-orcid":true,"given":"Xiang","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8783-2376","authenticated-orcid":true,"given":"Shiliang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx319"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccl.2021.06.002"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.kjms.2011.11.010"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-020-02354-8"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1395985"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2018.03.48"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0229888"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.914318"},{"issue":"6","key":"9","first-page":"1057","article-title":"Analysis of risk factors for acute lung injury\/acute respiratory distress syndrome after esophagectomy","volume":"50","author":"J. 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