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Demographics, clinical characteristics, comorbidities, and laboratory results were extracted from the patients\u2019 electronic records. Multivariable logistic and machine learning (ML) methods were used to study variable importance. Out of 1,613 COVID\u201019 patients, 1,004 (62.2%) were discharged from the hospital (survived), while 609 (37.8%) died. Patients who were of elderly age (&gt;65 years) (OR, 2.01; 95% CI, 1.28\u20133.16), current smokers (OR, 1.61; 95%CI, 1.17\u20132.23), and had severe or critical illness at admission ((OR, 1.56; 95%CI, 1.05\u20132.32) (OR, 2.94; 95%CI, 2.02\u20134.27); respectively), were at higher risk of mortality. Comorbidities including chronic kidney disease (OR, 2.90; 95% CI, 1.90\u20134.43), deep venous thrombosis (OR, 2.62; 95% CI, 1.08\u20136.35), malignancy (OR, 2.22; 95% CI, 1.46\u20133.38), diabetes (OR, 1.31; 95% CI, 1.04\u20131.65), and heart failure (OR, 1.51; 95% CI, 1.02\u20132.23) were significantly associated with increased risk of mortality. Laboratory abnormalities associated with mortality included hypernatremia (OR, 11.37; 95% CI, 4.33\u201329.81), elevated aspartate aminotransferase (OR, 1.81; 95% CI, 1.42\u20132.31), hypoalbuminemia (OR, 1.75; 95% CI, 1.37\u20132.25), and low platelets level (OR, 1.43; 95% CI, 1.05\u20131.95). Several demographic, clinical, and laboratory risk factors for COVID\u201019 mortality were identified. This study is the first to examine the risk factors associated with mortality using ML methods in the Middle East. This will contribute to a better understanding of the impact of the disease and improve the outcome of the pandemic worldwide.<\/jats:p>","DOI":"10.1155\/2022\/9617319","type":"journal-article","created":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T13:05:25Z","timestamp":1660655125000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Risk Factors Associated with Mortality in COVID\u201019 Hospitalized Patients: Data from the Middle East"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2919-1280","authenticated-orcid":false,"given":"Reema A.","family":"Karasneh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2160-4498","authenticated-orcid":false,"given":"Basheer 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